Abstract：
:Soluble amyloid beta protein (A beta)1-40 and highly amyloidogenic A beta 1-42/43 were immunocytochemically labeled in lysosomes of acinar cells and macrophages in the pancreas of transgenic mice systemically expressing a C-terminal fragment of the A beta precursor. A beta 1-42/43 and long A beta species extending their C-termini were detected in the detergent-insoluble fraction. Immunoreactivity of cathepsin D was markedly increased in lysosomes filled with A beta fibrils. These findings indicated that A beta 1-40, A beta 1-42, A beta 1-43 and longer A beta species were generated in the lysosomes of the transgenic pancreas, and suggested that the activation of cathepsin D, a candidate gamma-secretase, leads to acceleration of A beta amyloid formation.
journal_name
Brain Resjournal_title
Brain researchauthors
Kawarabayashi T,Igeta Y,Sato M,Sasaki A,Matsubara E,Kanai M,Tomidokoro Y,Ishiguro K,Okamoto K,Hirai S,Shoji Mdoi
10.1016/s0006-8993(97)00695-1subject
Has Abstractpub_date
1997-08-15 00:00:00pages
343-8issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00695-1journal_volume
765pub_type
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