Central projections of anuran optic nerves penetrating hindbrain or spinal cord regions of the neural tube.


:To identify parameters of optic tract growth that may be independent of the region of the CNS in which the tract develops, eye primordia of embryonic Rana pipiens were transplanted to a variety of ectopic locations adjacent to the hindbrain and spinal cord. Longitudinal growth direction, cross-sectional growth position and possible termination sites of ectopic optic tracts from transplanted eyes were analyzed in serial section autoradiographs following intraocular injection of [3H]proline. Sixteen animals ranging in age from Taylor and Kollros Stage I32 to one month postmetamorphosis were used in this study. The analysis revealed that retinal ganglion cell axons are capable of growing in both rostral and caudal directions within all regions of the hindbrain and spinal cord. Within comparable regions of the hindbrain and spinal cord, all ectopic optic tracts were located in identical cross-sectional positions. The positions were always sub-adjacent to the pial surface of the CNS and contiguous to regions of the neural axis in which sensory fiber tracts are normally found. Possible termination sites of ascending ectopic optic tracts were detected within sensory regions of the hindbrain and posterior midbrain tegmentum. However, there was no consistent selection of particular regions of termination. No ectopic optic nerve fibers extended significantly beyond the hindbrain-midbrain junction and no fibers could be traced to the optic tecta.


Brain Res


Brain research


Constantine-Paton M




Has Abstract


1978-12-08 00:00:00














  • Pathogenic role of autoantibodies against inhibitory synapses.

    abstract::Diverse neuropsychiatric diseases were recently linked to specific anti-neuronal autoantibodies targeting synaptic proteins. Symptoms can range from epileptic seizures to cognitive impairment to movement disorders, commonly responding to treatment with immunotherapy. Several of these autoantibodies target inhibitory s...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Prüss H,Kirmse K

    更新日期:2018-12-15 00:00:00

  • Hippocampal responses evoked by tooth pulp and acoustic stimulation: depth profiles and effect of behavior.

    abstract::Averaged evoked potentials and unitary discharges in response to tooth pulp and acoustic click stimuli were recorded from the hippocampus of freely moving rats. The spatial distribution of evoked field responses to tooth pulp stimulation and acoustic clicks were identical. Averaged evoked potentials consisted of a lar...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brankack J,Buzsáki G

    更新日期:1986-07-23 00:00:00

  • Sleep-wake disturbances in an animal model of chronic cholinergic insufficiency.

    abstract::Rats reared on a diet in which choline is replaced with N-aminodeanol (NADE), undergo > 50% replacement of brain acetylcholine with acetylated NADE, a false cholinergic transmitter. We examined amounts of sleep and wakefulness in 7 littermate pairs of rats fed either NADE-substituted, or a choline control diet for > 1...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Szymusiak R,McGinty D,Fairchild MD,Jenden DJ

    更新日期:1993-11-26 00:00:00

  • Intraischemic hypothermia during pretreatment with sublethal ischemia reduces the induction of ischemic tolerance in the gerbil hippocampus.

    abstract::We examined whether mild brain hypothermia during pretreatment with sublethal 2-min ischemia affected the tolerance to subsequent lethal 5-min ischemia. The neuronal densities in the hippocampal CA1 sector of gerbils preconditioned at mild brain hypothermia (32% of normal) were significantly lower than those in gerbil...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wada K,Miyazawa T,Katoh H,Nomura N,Yano A,Shima K,Chigasaki H

    更新日期:1997-01-23 00:00:00

  • The ultrastructure of group Ia afferent fiber synapses in the lumbosacral spinal cord of the cat.

    abstract::Ia synapses in laminae VI and IX of the cat's spinal cord were examined in the electron microscope following iontophoretic injection of horseradish peroxidase (HRP) into single, identified, Ia afferent fibers from gastrocnemius muscles. Ia boutons contacting motoneuron dendrites in lamina IX contained spherical synapt...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fyffe RE,Light AR

    更新日期:1984-05-23 00:00:00

  • Intracerebral xenografts of mouse bone marrow cells in adult rats facilitate restoration of cerebral blood flow and blood-brain barrier.

    abstract::We examined in the present study alterations in cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague-Dawley rats. Laser Doppler revealed that transplanted animals exhibited near normal...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Borlongan CV,Lind JG,Dillon-Carter O,Yu G,Hadman M,Cheng C,Carroll J,Hess DC

    更新日期:2004-05-29 00:00:00

  • Musical scale properties are automatically processed in the human auditory cortex.

    abstract::While listening to music, we immediately detect 'wrong' tones that do not match our expectations based on the prior context. This study aimed to determine whether such expectations can occur preattentively, as indexed by event-related potentials (ERPs), and whether these are modulated by attentional processes. To this...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brattico E,Tervaniemi M,Näätänen R,Peretz I

    更新日期:2006-10-30 00:00:00

  • Nitric oxide-mediated cGMP synthesis in Helix neural ganglia.

    abstract::The central nervous system of the mollusc Helix pomatia was stimulated with NO donors sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) or hydroxylamine, in the presence of a phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (IBMX). Radioimmunoassay revealed that all of the three NO donors signi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Huang S,Kerschbaum HH,Hermann A

    更新日期:1998-01-12 00:00:00

  • Quantitative autoradiographic analysis of the new radioligand [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382) at gamma-hydroxybutyric acid (GHB) binding sites in rat brain.

    abstract::(2E)-(5-Hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid (NCS-382) is an antagonist for gamma-hydroxybutyric acid (GHB) at GHB receptor sites. Advantages of using [(3)H]NCS-382 over [(3)H]GHB in radioligand binding studies are that unlike GHB, NCS-382 does not appear to bind to, activate, or i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gould GG,Mehta AK,Frazer A,Ticku MK

    更新日期:2003-07-25 00:00:00

  • Target cells for dihydrotestosterone in the guinea pig pituitary gland.

    abstract::Adult male guinea pigs were castrated and 24 h later injected with [3H]dihydrotestosterone. Their pituitary glands were then processed for autoradiographic and immunocytochemical analyses. Three percent of the parenchymal cells in the pars distalis were radiolabelled. These cells were primarily gonadotrophs; a small p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Herbert DC,Sheridan PJ

    更新日期:1986-01-08 00:00:00

  • Glycine-induced CA1 excitotoxicity in the rat hippocampal slice.

    abstract::We evaluated the effects of glycine exposure upon CA1-evoked response in the rat hippocampal slice. Exposure to 10 mM glycine for 16 min produced rapid neuronal firing and increased orthodromic population spike (PS), followed by loss of CA1 neural transmission. Upon recovery, CA1 orthodromic and antidromic PS regained...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wallis RA,Panizzon KL,Nolan JP

    更新日期:1994-11-21 00:00:00

  • Lipopolysaccharide injection into the cerebral ventricle evokes kininogen induction in the rat brain.

    abstract::Kinins, such as bradykinin and Lys-bradykinin, are important mediators in peripheral inflammation. Although the existence of the components necessary for generating kinins has been demonstrated in the brain, a functional role of the kinin-generating system in cerebral inflammation remains to be defined. The aim of the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Takano M,Horie M,Yayama K,Okamoto H

    更新日期:2003-07-18 00:00:00

  • Bipolar pathophysiology and development of improved treatments.

    abstract::The purpose of this review is to provide strategies and their rationale which can facilitate scientifically productive investigations into genetic, neuronal, brain functional and clinical aspects of bipolar disorder. The presentation addresses both factors that have impeded and those that have facilitated landmark adv...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Bowden CL

    更新日期:2008-10-15 00:00:00

  • Protein kinase C in focal ischemic rat brain: dual autoradiographic analysis of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu).

    abstract::Protein kinase C (PKC) activity was measured in rat brain with 2 h of middle cerebral artery (MCA) and common carotid artery (CCA) occlusion, using dual autoradiography of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu). In the ischemic brain, it required more than 120 min of incubation to obtain a p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tohyama Y,Sako K,Yonemasu Y

    更新日期:1997-03-07 00:00:00

  • Antiepileptic drugs prevent seizures in hyperbaric oxygen: A novel model of epileptiform activity.

    abstract::Breathing oxygen at sufficiently elevated pressures can trigger epileptiform seizures. Therefore, we tested the hypothesis that pre-treatment with FDA-approved antiepileptic drugs could prevent seizure onset in hyperoxia at 5 atmospheres absolute. We selected drugs from two putative functional categories, Na+-channel ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Demchenko IT,Zhilyaev SY,Moskvin AN,Krivchenko AI,Piantadosi CA,Allen BW

    更新日期:2017-02-15 00:00:00

  • Synaptic depression at a synapse in Aplysia californica: analysis in terms of a material flow model of neurotransmitter.

    abstract::When a pair of stimuli separated by an appropriate interval is given to the right visceropleural connective of Aplysia californica the amplitude of the second EPSP elicited in cell R15 is usually smaller than the amplitude of the first EPSP. In the present paper we show that this phenomenon, synaptic depression, can b...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Woodson PB,Schlapfer WT,Tremblay JP,Barondes SH

    更新日期:1976-06-04 00:00:00

  • Catecholamine utilization in specific rat brain nuclei after short-term hyperprolactinaemia.

    abstract::Endogenous hyperprolactinaemia was induced in intact male rats by transplantation of pituitaries under the kidney capsule. Five days later the utilization of noradrenaline (NA) and dopamine (DA) in individual brain nuclei and changes of plasma prolaction (PRL) were measured. Inhibition of catecholamine synthesis by al...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kovács GL,Drago F,Acsai L,Tihanyi A,Scapagnini U,Telegdy G

    更新日期:1984-12-17 00:00:00

  • Neurotransmitter-related markers in the normal and experimentally lesioned telencephalon of the goldfish.

    abstract::The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes. Experimental results (resection of the olfactory tracts or unilateral kainic acid administration in the telencephalon) suggest that: the projection from the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bissoli R,Contestabile A,Marotta L,Poli A,Migani P

    更新日期:1985-10-07 00:00:00

  • Postnatal development of rat peripheral nerves: an immunohistochemical study of membrane lipids common to non-myelin forming Schwann cells, myelin forming Schwann cells and oligodendrocytes.

    abstract::Interest in the role of membrane lipids in Schwann cell function prompted this study of lipid antigens on myelin- and non-myelin forming Schwann cells. Using the monoclonal antibodies 07, which recognises galactocerebroside, 08, 09 and 011, the distribution and time course of expression of the 4 membrane lipids have b...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Eccleston PA,Mirsky R,Jessen KR,Sommer I,Schachner M

    更新日期:1987-10-01 00:00:00

  • Methamphetamine induces macropinocytosis in differentiated SH-SY5Y human neuroblastoma cells.

    abstract::Acute and chronic abuses of psychostimulant drugs such as methamphetamine (METH) have been known to cause cell death. In particular, neurotoxicity caused by such drugs is one of the most serious adverse events in humans. Although various effects on neuronal cells caused by METH have been studied, the cellular and mole...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nara A,Aki T,Funakoshi T,Uemura K

    更新日期:2010-09-17 00:00:00

  • A comparison of human tactile stimulus velocity discrimination with the ability of S-I cortical neurons in awake rhesus monkeys to signal the same velocity differences before and after non-anesthetic doses of pentobarbital.

    abstract::Using psychophysical techniques, the ability of human subjects to discriminate the velocity of brush movement across the glabrous skin of the hand was determined. The same stimulus was then used in a series of neurophysiological experiments designed to determine the ability of neurons in the primary somatosensory cort...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Collins JG,Roppolo JR

    更新日期:1980-10-06 00:00:00

  • Lectin affinity and PAGE analysis of soluble axonally transported glycoconjugates in the rat visual system.

    abstract::Recent reports of the transsynaptic transfer of wheat germ agglutinin (WGA) in several systems are consistent with the hypothesis that WGA binds to endogenous glycoproteins(s) which undergo transsynaptic transfer. Such molecules might be involved in trophic interactions between neurons. Since these hypothetical glycop...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rhodes CH,Gonatas NK

    更新日期:1986-12-03 00:00:00

  • Lithium modulates cortical excitability in vitro.

    abstract::The sometimes devastating mood swings of bipolar disorder are prevented by treatment with selected antiepileptic drugs, or with lithium. Abnormal membrane ion channel expression and excitability in brain neurons likely underlie bipolar disorder, but explaining therapeutic effects in these terms has faced an unresolved...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Butler-Munro C,Coddington EJ,Shirley CH,Heyward PM

    更新日期:2010-09-17 00:00:00

  • Nitric oxide synthase is concentrated at the skeletal muscle endplate.

    abstract::NO performs a wide array of cell signaling functions. Neuronal NO synthase (nNOS) immunoreactivity and nicotinamide adenine dinucleotide phosphate diaphorase (NDP) activity, a marker of nNOS, were concentrated at adult rat neuromuscular junctions and persisted in denervated muscle indicating the localization of the en...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kusner LL,Kaminski HJ

    更新日期:1996-08-19 00:00:00

  • Distribution of corticotropin-releasing factor mRNA and immunoreactivity in the central auditory system of the rat.

    abstract::Hybridization histochemical and immunohistochemical methods were used to characterize the distribution of corticotropin-releasing factor (CRF) messenger RNA (mRNA) and peptide, respectively, in the central auditory system of the rat. Cell bodies expressing CRF mRNA and/or immunoreactivity (IR) were detected at each le...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Imaki J,Imaki T,Vale W,Sawchenko PE

    更新日期:1991-04-26 00:00:00

  • 1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanisms.

    abstract::Apoptosis has been shown to be induced by some pathological stimuli. MPP+ is a neurotoxin and an inducer of parkinsonism. When SH-SY5Y cells, human neuroblastoma cell line, were treated with MPP+, cell death estimated by lactate dehydrogenase (LDH) leakage assay occurred. The cell death was associated with the DNA fra...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Itano Y,Nomura Y

    更新日期:1995-12-18 00:00:00

  • Caffeine-diazepam interaction and local cerebral glucose utilization in the conscious rat.

    abstract::The quantitative 2-[14C]deoxyglucose autoradiographic method was used to study the effects of the acute administration of a sedative anticonvulsant dose of diazepam (2 mg/kg) on rat brain energy metabolism. This benzodiazepine was injected to rats chronically treated for two weeks either by caffeine (10 mg/kg/day) or ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nehlig A,Daval JL,Pereira de Vasconcelos A,Boyet S

    更新日期:1987-09-01 00:00:00

  • Loss of benefit from estrogen replacement therapy in diabetic ovariectomized female rats subjected to transient forebrain ischemia.

    abstract::In nondiabetic animals, estrogen has been shown to provide significant neuroprotection in focal and transient forebrain ischemia models. However, that neuroprotection may be diminished or lost in the diabetic. In this study, we compared the level of brain damage in intact, ovariectomized (OVX) and 17beta-estradiol (E(...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Santizo RA,Xu HL,Ye S,Baughman VL,Pelligrino DA

    更新日期:2002-11-22 00:00:00

  • Chronoamperometry in brain slices: quantitative evaluations of in vivo electrochemistry.

    abstract::Practical utilization of in vivo electrochemistry for brain studies has been impeded by difficulties with specificity and quantitative measurements. Studies in brain slices combined with similar data from intact animals have provided important new information on the nature of the electrochemical studies. Using the enz...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schenk JO,Miller E,Rice ME,Adams RN

    更新日期:1983-10-24 00:00:00

  • Electrophysiological evidence for an increase in the number of ventral root afferent fibers after neonatal peripheral neurectomy in the rat.

    abstract::Our recent study has shown that many afferent fibers in the ventral root are third branches of dorsal root ganglion cells in addition to their processes in the peripheral nerve and the dorsal root. From results of this study, we hypothesized that most of the afferent fibers in the normal ventral root are extra process...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Oh UT,Kim KJ,Baik-Han EJ,Chung JM

    更新日期:1989-10-30 00:00:00