Central projections of anuran optic nerves penetrating hindbrain or spinal cord regions of the neural tube.


:To identify parameters of optic tract growth that may be independent of the region of the CNS in which the tract develops, eye primordia of embryonic Rana pipiens were transplanted to a variety of ectopic locations adjacent to the hindbrain and spinal cord. Longitudinal growth direction, cross-sectional growth position and possible termination sites of ectopic optic tracts from transplanted eyes were analyzed in serial section autoradiographs following intraocular injection of [3H]proline. Sixteen animals ranging in age from Taylor and Kollros Stage I32 to one month postmetamorphosis were used in this study. The analysis revealed that retinal ganglion cell axons are capable of growing in both rostral and caudal directions within all regions of the hindbrain and spinal cord. Within comparable regions of the hindbrain and spinal cord, all ectopic optic tracts were located in identical cross-sectional positions. The positions were always sub-adjacent to the pial surface of the CNS and contiguous to regions of the neural axis in which sensory fiber tracts are normally found. Possible termination sites of ascending ectopic optic tracts were detected within sensory regions of the hindbrain and posterior midbrain tegmentum. However, there was no consistent selection of particular regions of termination. No ectopic optic nerve fibers extended significantly beyond the hindbrain-midbrain junction and no fibers could be traced to the optic tecta.


Brain Res


Brain research


Constantine-Paton M




Has Abstract


1978-12-08 00:00:00














  • Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis, upper cervical cord, NTS and Pa5 following capsaicin injection into masticatory and swallowing-related muscles in rats.

    abstract::Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after capsaicin injection into the whisker pad (WP), masseter ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tsujimura T,Shinoda M,Honda K,Hitomi S,Kiyomoto M,Matsuura S,Katagiri A,Tsuji K,Inoue M,Shiga Y,Iwata K

    更新日期:2011-10-12 00:00:00

  • The interpeduncular nucleus excites the on-cells and inhibits the off-cells of the nucleus raphe magnus.

    abstract::The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cel...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hentall ID,Budhrani VM

    更新日期:1990-07-09 00:00:00

  • Enhancement of footshock-induced analgesia by spinal 5,7-dihydroxytryptamine lesions.

    abstract::The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hutson PH,Tricklebank MD,Curzon G

    更新日期:1982-04-15 00:00:00

  • Physiological and anatomical properties of the suprachiasmatic nucleus of an anophthalmic mouse.

    abstract::Congenitally anophthalmic mice (ZRDCT-AN) have circadian rhythms which 'free-run' and are not light modulated. Their rhythms differ from those of controls in: duration of circadian period, length of active phase, and pattern/intensity of activity. Three different populations have been described based upon wheel-runnin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Laemle LK,Hori N,Strominger NL,Tan Y,Carpenter DO

    更新日期:2002-10-25 00:00:00

  • Cytokines regulate c-Met expression in cultured astrocytes.

    abstract::We investigated c-Met expression in cultured astrocytes and their regulation by cytokines. Immunocytochemistry revealed that c-Met was expressed in cultured astrocytes. Western blotting revealed that acidic and basic fibroblast growth factor (FGF) enhanced and hepatocyte growth factor (HGF) reduced c-Met expression. R...

    journal_title:Brain research

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    authors: Shimazaki K,Yoshida K,Hirose Y,Ishimori H,Katayama M,Kawase T

    更新日期:2003-02-07 00:00:00

  • A light and electron microscopic study of calbindin D-28k immunoreactive double bouquet cells in the human temporal cortex.

    abstract::Correlative light and electron microscopic methods were used to examine the morphology, distribution and synaptic connections of double bouquet cells immunoreactive for the calcium-binding protein calbindin D-28k in the human temporal neocortex. Double bouquet cells form symmetric synapses with small dendritic shafts ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: del Río MR,DeFelipe J

    更新日期:1995-08-28 00:00:00

  • An analysis of the mechanisms underlying septal area control of hypothalamically elicited aggression in the cat.

    abstract::This experiment was performed in order to examine several of the underlying mechanisms by which the septal area and adjacent regions regulate quiet biting attack behavior elicited from electrical stimulation of the hypothalamus in the cat. The results clearly indicate that stimulation of the septal area and anterior c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brutus M,Shaikh MB,Siegel HE,Siegel A

    更新日期:1984-09-24 00:00:00

  • Transient and compartmental expression of the reeler gene product reelin in the developing rat striatum.

    abstract::Mammalian neostriatum is composed of two neurochemically and neuroanatomically defined compartments, called the patches and matrix. The present study concerns a search for neurochemical molecules involved in formation of the striatal compartments. Using the monoclonal antibody CR-50, we here disclose a transient expre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nishikawa S,Goto S,Hamasaki T,Ogawa M,Ushio Y

    更新日期:1999-12-11 00:00:00

  • Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment.

    abstract::Amnestic type mild cognitive impairment (aMCI) refers to a transitional stage between normal aging and Alzheimer's disease (AD). Whilst posterior cingulate cortex (PCC) is believed to have a key role in a default network and be involved in the pathophysiology of AD, few studies have investigated whole-brain functional...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bai F,Watson DR,Yu H,Shi Y,Yuan Y,Zhang Z

    更新日期:2009-12-11 00:00:00

  • Dependence of axolemmal differentiation on contact with glial cells in chronically demyelinated lesions of cat spinal cord.

    abstract::Chronically demyelinated lesions of cat dorsal columns were created by focal injection of the glial toxin ethidium bromide. Freeze-fracture studies show that the center of the lesion, which is devoid of glial cells and processes, contains axons having neither node-like nor paranodal-type membrane specializations. Near...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rosenbluth J,Tao-Cheng JH,Blakemore WF

    更新日期:1985-12-09 00:00:00

  • Serotonin neurons grafted to the adult rat hippocampus. I. Time course of growth as studied by immunohistochemistry and biochemistry.

    abstract::The maturation and growth of fetal serotonergic raphe neurons have been studied immunohistochemically and biochemically between 1 week and 5 months after grafting to the hippocampal formation in 5,7-dihydroxytryptamine-pretreated adult rats. The average number of surviving neurons in each group was 1800, which is equi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Daszuta A,Strecker RE,Brundin P,Björklund A

    更新日期:1988-08-16 00:00:00

  • Prenatal immune challenge in rats increases susceptibility to seizure-induced brain injury in adulthood.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yin P,Liu J,Li Z,Wang YY,Qiao NN,Huang SY,Li BM,Sun RP

    更新日期:2013-06-26 00:00:00

  • GABA-receptor stimulation enhances norepinephrine-induced polyphosphoinositide metabolism in rat hippocampal slices.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Corradetti R,Ruggiero M,Chiarugi VP,Pepeu G

    更新日期:1987-05-12 00:00:00

  • Increased GABA binding in mouse brain following acute swim stress.

    abstract::Acute swim stress of mice produces increases in the density of high and low affinity binding sites in the brain for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), together with analgesia as measured by an increase in tail flick latency. Apparent tolerance develops in repeated swimming with analgesia a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Skerritt JH,Trisdikoon P,Johnston GA

    更新日期:1981-06-29 00:00:00

  • Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract.

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    authors: Rusak B,Meijer JH,Harrington ME

    更新日期:1989-07-31 00:00:00

  • Increased density of perivascular nerves to the major cerebral vessels of the spontaneously hypertensive rat: differential changes in noradrenaline and neuropeptide Y during development.

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    journal_title:Brain research

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    authors: Dhital KK,Gerli R,Lincoln J,Milner P,Tanganelli P,Weber G,Fruschelli C,Burnstock G

    更新日期:1988-03-15 00:00:00

  • Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats.

    abstract::A hypothalamic oxytocinergic-descending pathway that reaches the dorsal horn of the spinal cord has been well documented and recently related to states of pain and analgesia. In order to study the action of the neuropeptide oxytocin (OT) on pain-related responses, we compared dorsal horn neuronal responses to electric...

    journal_title:Brain research

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    authors: Condés-Lara M,Maie IA,Dickenson AH

    更新日期:2005-05-31 00:00:00

  • Bcl-2 overexpression disrupts the morphology of PC12 cells through reduced ERK activation.

    abstract::Bcl-2 has been hypothesized to regulate many cellular functions in addition to its well-characterized role in the prevention of programmed cell death. To understand the role of Bcl-2 in regulating cell morphology and to explore the mechanism of this effect, we examined the effects of Bcl-2 overexpression on the morpho...

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    authors: Mi Z,Mirnics ZK,Schor NF

    更新日期:2006-09-27 00:00:00

  • Measurement of gamma-enolase release, a new method for selective quantification of neurotoxicity independently from glial lysis.

    abstract::We have developed a sensitive enzymatic-immunoassay to quantify the level of gamma-enolase (a specific neuronal enzyme) which is released from cultured cells after exposure to various toxins. We show that this method can estimate selectively neuronal cell death without significantly interfering with glial cell death. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lafon-Cazal M,Bougault I,Steinberg R,Pin JP,Bockaert J

    更新日期:1992-10-09 00:00:00

  • Evidence to suggest that cytosolic acetylcholine in rat hippocampal nerve terminals is not directly transferred into synaptic vesicles for release.

    abstract::Rat hippocampal minces were loaded with [acetyl 1-14C]acetylcholine ([14C]ACh) in the presence of the "poorly penetrating" acetylcholinesterase (EC; AChE) inhibitor echothiophate and the effect of high K+ depolarization determined on the subcellular storage and release of [14C]ACh and its metabolites. Results ...

    journal_title:Brain research

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    authors: Carroll PT

    更新日期:1996-06-24 00:00:00

  • Development of somatostatin immunoreactive neurons in rat retina.

    abstract::Levels of somatostatin-like immunoreactivity (SLI) were measured in the rat retina by radioimmunoassay during prenatal and postnatal development. SLI-containing cells were visualized by immunocytochemistry throughout this time period. SLI is present as early as embryonic day 15 (E15) and by E16 at concentrations 10-fo...

    journal_title:Brain research

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    authors: Ferriero DM,Sagar SM

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  • Alpha-adrenergic activation of rat hypothalamic supraoptic neurons maintained in vitro.

    abstract::Extracellular recordings from 141 rat supraoptic nucleus neurons maintained in vitro in a perfused hypothalamic explant indicated that the excitability of 85% of cells was enhanced by the addition of 10-200 microM norepinephrine (NE) and the alpha-agonist methoxamine (MOXY), but not by isoproterenol, to the perfusion ...

    journal_title:Brain research

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    authors: Randle JC,Bourque CW,Renaud LP

    更新日期:1984-07-30 00:00:00

  • On the projections from the vestibular and perihypoglossal nuclei to the spinal trigeminal and lateral reticular nuclei in the cat.

    abstract::The projection from the vestibular and perihypoglossal nuclei to the spinal trigeminal and lateral reticular nuclei has been studied in cats where the wheat germ agglutinin-horseradish peroxidase complex has been used as a retrograde tracer. All injections were made at the level of the caudal pole of the inferior oliv...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Walberg F,Dietrichs E,Nordby T

    更新日期:1985-04-29 00:00:00

  • SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity.

    abstract::Parkinson's disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Several factors such as inhibition of the mitochondrial respiration, generation of hydroxyl radicals and reduced free radical defense mechanisms causing oxidative stress, have been postulated to contribute to t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Muralikrishnan D,Ebadi M

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gilad G,Reis DJ

    更新日期:1978-06-23 00:00:00

  • Isolation and characterization of putative O2 chemoreceptor cells from the gills of channel catfish (Ictalurus punctatus).

    abstract::Little is known about the cells or mechanisms of O2 chemoreception in vertebrates other than mammals. The purpose of this study, therefore, was to identify O2-sensitive chemoreceptors in a fish. Putative O2-sensitive chemoreceptors were dissociated from the gills of channel catfish, Ictalurus punctatus, and cultured. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Burleson ML,Mercer SE,Wilk-Blaszczak MA

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  • Immunohistochemical localization of a lectin-like molecule, R1, during the postnatal development of the rat cerebellum.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dontenwill M,Roussel G,Zanetta JP

    更新日期:1985-01-01 00:00:00

  • Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis.

    abstract::The present study determined whether cortical cholinergic neurons recover functionally following the loss of afferent projections from the nucleus basalis magnocellularis (nbm). At various time points following ibotenic acid lesions of the nbm, choline acetyltransferase (ChAT) activity or the capacity of cortical chol...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lapchak PA,Araujo DM,Pasinetti G,Hefti F

    更新日期:1993-06-11 00:00:00

  • Identification of neuron subpopulations in the rat vestibular ganglion by calbindin-D 28K, calretinin and neurofilament proteins immunoreactivity.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Demêmes D,Raymond J,Atger P,Grill C,Winsky L,Dechesne CJ

    更新日期:1992-06-05 00:00:00

  • Evaluation of blood vessel and neurite growth into a collagen matrix placed within a surgically created gap in rat spinal cord.

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    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gelderd JB

    更新日期:1990-03-12 00:00:00