Abstract：
:The presence of corticotropin releasing factor (CRF)-immunoreactive nerve fibers and cell bodies in the spinal cord is demonstrated. Immunopositive fibers were found in the lateral column of the white matter, in laminae I, V-VII, X, and in the intermediolateral column of the spinal cord. Complete transection of the spinal cord showed that the majority of the fibers in the lateral funiculus formed an ascending pathway; however, a few descending fibers were also detected. Hypophysectomy resulted in enhanced immunoreactivity of the fibers and staining of CRF-immunoreactive cell bodies in laminae V-VII, X, and in the intermediolateral sympathetic column. The results suggest that CRF is not merely an ACTH releasing factor, but also a regulatory peptide which may be involved in several stress-related neural responses.
journal_name
Brain Resjournal_title
Brain researchauthors
Merchenthaler I,Hynes MA,Vigh S,Shally AV,Petrusz Pdoi
10.1016/0006-8993(83)91001-6subject
Has Abstractpub_date
1983-09-26 00:00:00pages
373-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)91001-6journal_volume
275pub_type
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