Deregulation of autophagy and vesicle trafficking in Parkinson's disease.

abstract：:The specific phosphatase inhibitor, Calyculin-A (CL-A), decreases high-K stimulated catecholamine secretion in bovine chromaffin cells. This effect can be split into two components: one needs long exposures to the drug to be elicited, and is sensitive to the protein kinase-inhibitor K252a; the other is observed after ...

journal_title：Neuroscience letters

authors： Gutiérrez LM,Viniegra S,Quintanar JL,Reig JA,Sala F

更新日期：1994-08-29 00:00:00

abstract：:Muscle vibration does not affect post-synaptic excitability of the corresponding motoneuronal pool, the concurrent depression of the monosynaptic reflex resulting from a pre-motoneuronal block of Ia spindle afferents. Indeed (1) both homonymous and heteronymous soleus responses (to electrical stimulation of the poster...

journal_title：Neuroscience letters

authors： Abbruzzese M,Minatel C,Faga D,Favale E

更新日期：1997-08-08 00:00:00

abstract：:The modulation by endogenous polyamine spermine on acetylcholine (ACh)-induced currents was evaluated using a outside-out patch and whole-cell voltage-clamp recordings from cultured Xenopus muscle cells. Spermine potentiated the ACh-induced whole-cell currents at micromolar concentrations but is less effective at mill...

journal_title：Neuroscience letters

authors： Hsu KS

更新日期：1994-11-21 00:00:00

abstract：:This study in lampreys (Lampetra fluviatilis L.) is concerned with the phylogenetic age of the suprachiasmatic nucleus of the hypothalamus which in mammals receives input from the retinohypothalamic tract and acts as circadian pacemaker. Tracing experiments with the fluorescent dye DiI demonstrated a retinohypothalami...

journal_title：Neuroscience letters

authors： Weigle C,Wicht H,Korf HW

更新日期：1996-10-18 00:00:00

abstract：:Sciatic section in rats evokes chronic hyperalgesia, autotomy pain behavior, and hindpaw edema, a constellation resembling complex regional pain syndrome (CRPS) in man. Glucocorticoid treatment inhibits these sequelae of sciatic section and also blocks neurogenic extravasation. Small diameter afferent neurons release ...

journal_title：Neuroscience letters

authors： Kingery WS,Agashe GS,Guo TZ,Davies MF,Clark JD,Maze M

更新日期：2002-01-18 00:00:00

abstract：:UBB+1 protein is an aberrant ubiquitin associated with progressive supranuclear palsy (PSP). It leads to proteasome inhibition, heat-shock protein (HSP) expression and apoptosis in cell cultures. Despite UBB+1 polyubiquitination (an indication of proteasome inhibition), we demonstrate that UBB+1 and HSP40/HSP70 immuno...

journal_title：Neuroscience letters

authors： Hope AD,Lashley T,Lees AJ,de Silva R

更新日期：2004-04-08 00:00:00

abstract：:The magnetic cell sorter (MACS) technique was applied to isolate retinal ganglion cells (RGCs) for culture. RGCs were labeled retrogradely with 1.1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil). Subsequently retinal cell suspensions were incubated with biotinylated anti-rat Thy-1 antibody and MA...

journal_title：Neuroscience letters

authors： Shoge K,Mishima HK,Mukai S,Shinya M,Ishihara K,Kanno M,Sasa M

更新日期：1999-01-08 00:00:00

abstract：:The activity of the septo-hippocampal cholinergic pathway was investigated by measuring changes in the extracellular acetylcholine (ACh) levels in the hippocampus, by means of microdialysis, during the operant conditioned reflex and the repeated footshock stimulus. Microdialysis samplings were conducted in a Skinner b...

journal_title：Neuroscience letters

authors： Dong Y,Mao J,Shangguan D,Zhao R,Liu G

更新日期：2004-10-14 00:00:00

abstract：:Agonist-induced turnover or release of inositolphosphates (IP) was studied in the dorsal and the ventral hippocampus 24 h, 1 month, and 3 months after the last electrical stimulus of kindled rats. A significant increase in acetylcholine (ACh)-stimulated IP turnover was observed in dorsal, but not ventral, hippocampus ...

journal_title：Neuroscience letters

authors： Zhang WQ,Tandon P,Sobotka TJ,Hong JS,Tilson HA

更新日期：1990-10-02 00:00:00

abstract：:The effect of preconditioning (PC) on the changes of nerve growth factor-induced gene A (NGFI-A) expression induced by severe hypobaric hypoxia was studied by in situ hybridization. A PC consisted of three trials of mild hypobaric hypoxia (360 Torr, 2 h) spaced at 24 h. The last trial was followed by severe hypoxia (S...

journal_title：Neuroscience letters

authors： Rybnikova E,Tulkova E,Pelto-Huikko M,Samoilov M

更新日期：2002-08-23 00:00:00

abstract：:Dystrobrevin is a newly discovered dystrophin-associated protein that is classified as alpha- and beta-dystrobrevin. Previous studies reported that dystrophin, utrophin, syntrophin and beta-dystroglycan were expressed in the cerebellum. In the present study, we examined cellular and subcellular localization of dystrob...

journal_title：Neuroscience letters

authors： Ueda H,Baba T,Terada N,Kato Y,Fujii Y,Takayama I,Mei X,Ohno S

更新日期：2000-04-07 00:00:00

abstract：:Lowering extracellular calcium concentration [Ca2+]o in rat hippocampal slices can lead to an induction of epileptiform activity. It has been shown that this effect is more pronounced in slices of neonatal rats (postnatal day, PND 8-19) than in mature slices (> PND 40) and it has been suggested that unique N-methyl-D-...

journal_title：Neuroscience letters

authors： Gorter JA,Brady RJ

更新日期：1995-07-21 00:00:00

abstract：:We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influ...

journal_title：Neuroscience letters

authors： Houlden H,Rizzu P,Stevens M,de Knijff P,van Duijn CM,van Swieten JC,Heutink P,Perez-Tur J,Thomas V,Baker M,Morris H,Rossor M,Jannsen JC,Petersen RC,Dodd P,Dark F,Boeve B,Dickson D,Davies P,Pickering-Brown S,Mann D

更新日期：1999-02-05 00:00:00

abstract：:Ribonuclease protection assays were performed on the basal hypothalamus (BH), the preoptic area (POA) and the thalamus (THAL) from female guinea pigs that were ovariectomized and implanted with morphine (n = 8) or placebo (n = 8) pellets for 1 week. An antisense [32P]rUTP labeled riboprobe, representing a 280 bp fragm...

journal_title：Neuroscience letters

authors： Rønnekleiv OK,Bosch MA,Cunningham MJ,Wagner EJ,Grandy DK,Kelly MJ

更新日期：1996-09-27 00:00:00

abstract：:Vascular cognitive impairment (VCI) is the second most common cause of dementia after Alzheimer's disease, and the cognitive impairment is one of the common effects of VCI. Unfortunately, it lacks effective therapeutic treatments at present. In our previous study, environmental enrichment (EE), as an early interventio...

journal_title：Neuroscience letters

authors： Xu L,Qu C,Qu C,Shen J,Song H,Li Y,Li T,Zheng J,Zhang J

更新日期：2020-11-20 00:00:00

abstract：:Neural circuitry comprising the ventral tegmental area, nucleus accumbens (NAc), prefrontal cortex (PFC) and hippocampus (HIP) has a main role in reward phenomena. Previous behavioral studies indicated that intracerebroventricular administration of AP5 (NMDA glutamate receptor antagonist) and CNQX (AMPA/kainate glutam...

journal_title：Neuroscience letters

authors： Siahposht-Khachaki A,Ezzatpanah S,Razavi Y,Haghparast A

更新日期：2018-01-01 00:00:00

abstract：:Dopamine D1 and D2 receptors were studied in putamen of post-mortem brains from controls and patients with Alzheimer-type dementia (ATD). A significant reduction in dopamine D2 receptors was observed in ATD, whereas dopamine D1 receptors were unchanged. Neurochemical markers of striatal acetylcholine and GABA-containi...

journal_title：Neuroscience letters

authors： Cross AJ,Crow TJ,Ferrier IN,Johnson JA,Markakis D

更新日期：1984-11-23 00:00:00

abstract：:Growth factors are major signaling agents regulating neuron-glia dialogue. Epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), insulin growth factor-I (IGF-I) and insulin (INS) induce neuronal and astroglial cell proliferation and differentiation. This is true also for estrogens that influence astroc...

journal_title：Neuroscience letters

authors： Avola R,Mignini F,Mazzone V,Fisichella A,Zaccheo D,Tomassoni D

更新日期：2004-04-01 00:00:00

abstract：:Neurons simultaneously immunoreactive with anti-beta-endorphin and anti-(17-39) corticotropin (anti(17-39) ACTH) have been detected in the arcuate and ventromedial nuclei of the hypothalamus of colchicine-treated rats. These neurons are different from those fluorescent with the Falck and Hillarp technique. These resul...

journal_title：Neuroscience letters

authors： Bugnon C,Bloch B,Lenys D,Gouget A,Fellmann D

更新日期：1979-09-01 00:00:00

abstract：:The effect of dopamine on the 3',5'-cyclic adenosine monophosphate (cAMP) generating system of membrane particles of rat prostate gland was studied. Dopamine increased the concentration of cAMP in a dose-dependent manner. The selective D1 receptor inhibitor SCH 23390 caused a decrease in dopamine-elicited cAMP levels....

journal_title：Neuroscience letters

authors： Amenta D,Cavallotti C,Amenta F

更新日期：1987-06-01 00:00:00

abstract：:Both the onset of and recovery from desensitization of three types of responses to acetylcholine in Aplysia californica occurred by biphasic kinetics. The fast component of onset recovered at a slower rate than the slow component of onset. The rates of onset and recovery were widely different when the three response t...

journal_title：Neuroscience letters

authors： Chesnut TJ,Carpenter DO

更新日期：1983-09-09 00:00:00

abstract：:The repressor element-1 silencing transcription factor (REST) has emerged as a key controller of neuronal differentiation and has been shown to play a critical role in the expression of the neuronal phenotype; however, much has still to be learned about its role at specific developmental stages and about the functiona...

journal_title：Neuroscience letters

authors： Antoniotti S,Ruffinatti FA,Torriano S,Luganini A,D'Alessandro R,Lovisolo D

更新日期：2016-08-26 00:00:00

abstract：:The sigma-1 (σ1) receptor is a chaperone protein located on the mitochondria-associated membrane of the endoplasmic reticulum, while the sigma-2 receptor (σ2) is an endoplasmic reticulum-resident membrane protein. Recent evidence indicates that both of these receptors figure prominently in the pathophysiology of Alzhe...

journal_title：Neuroscience letters

authors： Jia H,Zhang Y,Huang Y

更新日期：2019-01-19 00:00:00

abstract：:The localization of amyloid beta protein (A beta), A beta 40, A beta 42, and transthyretin (TTR) was investigated immunohistochemically in the autopsied human kidney, using polyclonal antibodies against TTR, A beta and C-terminal end-specific antibodies against A beta 40 and 42. Immunoreactivities of A beta and A beta...

journal_title：Neuroscience letters

authors： Tsuzuki K,Fukatsu R,Hayashi Y,Yoshida T,Sasaki N,Takamaru Y,Yamaguchi H,Tateno M,Fujii N,Takahata N

更新日期：1997-02-07 00:00:00

abstract：:Early intervention following combat deployment has the potential to prevent posttraumatic stress disorder (PTSD), but there is a need for greater understanding of the factors that contribute to PTSD symptom progression. This study investigated: (1) fear-potentiated startle during a fear extinction, (2) white matter mi...

journal_title：Neuroscience letters

authors： Costanzo ME,Jovanovic T,Pham D,Leaman S,Highland KB,Norrholm SD,Roy MJ

更新日期：2016-04-08 00:00:00

abstract：:The electron microscopic findings in cats after complete interruption of all afferents to caudate nucleus as well as of its efferent fibers, suggest that the type IX synapses, the presynaptic component of which contains large empty round vesicles, are formed by the axon terminals of intrinsic neurons. They make synapt...

journal_title：Neuroscience letters

authors： Hassler R,Chung JW,Wagner A,Rinne U

更新日期：1977-07-01 00:00:00

abstract：:We immunohistochemically examined the expression of glycogen synthase kinase-3beta (GSK-3beta) in the brains of Parkinson's disease (PD) patients. GSK-3beta was localized in punctate structures in the cytosol of subsets of neurons in the midbrain and upper pons. GSK-3beta was also localized in Lewy bodies (LBs) as was...

journal_title：Neuroscience letters

authors： Nagao M,Hayashi H

更新日期：2009-01-09 00:00:00

abstract：:Dopaminergic neurons of the goldfish retina were selectively destroyed after a single intravitreal injection of 1-methyl-4-phenylpyridinium ion (MPP+). The ultrastructural analysis of the retina 3 days after toxin administration shows darkening of some retinal neurons present in the inner nuclear layer including their...

journal_title：Neuroscience letters

authors： Villani L,Poli A,Bissoli R,Barnabei O

更新日期：1988-03-31 00:00:00

abstract：:We evaluated whether brain-derived neurotrophic factor (BDNF) can stimulate choline acetyltransferase (ChAT) activity in the septo-hippocampal pathway of ethylcholine mustard aziridinium (AF64A) and non-AF64A-treated rats. Rats received either AF64A (1.5 nmol/ ventricle) or a sham (non-AF64A-treated) injection into th...

journal_title：Neuroscience letters

authors： Willson CA,Hanin I

更新日期：1997-07-04 00:00:00

abstract：:The efficacy of beta 1-adrenoceptor-G protein coupling was studied in postmortem temporal cortex synaptic membranes from a series of control and Alzheimer's disease subjects. For the control cases, the non-hydrolysable GTP analogue 5'-guanylylimidodiphosphate (Gpp[NH]p) gave a significant reduction in the affinity of ...

journal_title：Neuroscience letters

authors： Cowburn RF,Vestling M,Fowler CJ,Ravid R,Winblad B,O'Neill C

更新日期：1993-06-11 00:00:00