Abstract:
:UBB+1 protein is an aberrant ubiquitin associated with progressive supranuclear palsy (PSP). It leads to proteasome inhibition, heat-shock protein (HSP) expression and apoptosis in cell cultures. Despite UBB+1 polyubiquitination (an indication of proteasome inhibition), we demonstrate that UBB+1 and HSP40/HSP70 immunoreactivity do not co-localize in the pons of patients with PSP. As HSPs are involved in both normal tau and proteasome function, these findings may be relevant to the aetiology of PSP and other tauopathies.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hope AD,Lashley T,Lees AJ,de Silva Rdoi
10.1016/j.neulet.2003.12.127keywords:
subject
Has Abstractpub_date
2004-04-08 00:00:00pages
94-8issue
1-2eissn
0304-3940issn
1872-7972pii
S0304394004001375journal_volume
359pub_type
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