Abstract:
:The expression of dystrophin-protein 71 (Dp71) was investigated during nerve growth factor (NGF) induced differentiation of PC12 cells. A semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) assay was designed to measure Dp71 mRNA, whereas the Dp71 protein amount was evaluated by immunoblot analysis using an anti-dystrophin monoclonal antibody. Comparison with control cultures showed that Dp71 mRNA and protein levels increased in parallel with NGF treatment peaking with increments of 60% and 1.4 times, respectively. The upregulation of Dp71 expression during PC12 cells differentiation point at PC12 cells as a suitable model for studying the function of Dp71 in neuronal cells.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cisneros B,Rendon A,Genty V,Aranda G,Marquez F,Mornet D,Montañez Cdoi
10.1016/0304-3940(96)12863-9subject
Has Abstractpub_date
1996-08-02 00:00:00pages
107-10issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(96)12863-9journal_volume
213pub_type
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