Abstract:
:Discrete brain structures were analysed for gamma-aminobutyric acid (GABA) and vasopressin content in normo- and hypotensive rats treated with the glutamic acid decarboxylase inhibitor, 3-mercaptopropionic acid (MPA) and the GABAA agonist muscimol. In the normotensive group treated with MPA only, the concentration of vasopressin increased in the supraoptic nucleus, indicating an inhibitory role for GABA. In the hypotensive group a rise in the vasopressin level in the nucleus of the solitary tract was detected and the GABA level decreased in the supraoptic nucleus. Muscimol decreased the concentration of vasopressin in the nucleus of the solitary tract. The changes in the concentration of vasopressin may be a result of increased or decreased activation of the GABAergic system. The results show that the GABA- and vasopressinergic systems somehow interact although the more precise way of action remains to be clarified.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Magnusson A,Höglund U,Sjöquist Mdoi
10.1016/0304-3940(89)90546-6subject
Has Abstractpub_date
1989-07-03 00:00:00pages
281-7issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(89)90546-6journal_volume
101pub_type
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