Abstract：
:Conflicting inputs from visual and vestibular afferents produce motion sickness and postural instability. However, the relationship of visual and vestibular inputs to each other remains obscure. In this study, we examined the development of subjective sickness- and balance-related symptoms and objective equilibrium ataxia induced by visual-vestibular conflict (VVC) stimulation using virtual reality. The subjective symptoms evaluated by Graybiel's and Hamilton's criteria got gradually worse during the VVC. The objective postural instability was not observed during the VVC, but it occurred immediately after the VVC. There was a time lag between the subjective symptoms and objective ataxia induced by VVC. Our study suggests that the VVC inputs are processed in different pathways causing subjective autonomic symptoms and postural instability in humans.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Akiduki H,Nishiike S,Watanabe H,Matsuoka K,Kubo T,Takeda Ndoi
10.1016/s0304-3940(03)00098-3keywords:
subject
Has Abstractpub_date
2003-04-17 00:00:00pages
197-200issue
3eissn
0304-3940issn
1872-7972pii
S0304394003000983journal_volume
340pub_type
杂志文章abstract：:Converging evidence demonstrates an important role for gangliosides in brain function and neurodegenerative diseases. Exogenous GM1 is broadly neuroprotective, including in rodent, feline, and primate models of Parkinson's disease, and has shown positive effects in clinical trials. We and others have shown that inhibi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.10.038
更新日期：2019-01-23 00:00:00
abstract：:Na+, K+-ATPase is one of major membrane proteins that has two subunits, alpha and beta. The alpha subunit has the ATPase activity and the ouabain binding site. Among four isoforms of the alpha subunit, expression of alpha1, alpha2, and alpha3, but not alpha4, is observed in matured rat brain. Ouabain is one of cardiac...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.11.061
更新日期：2007-02-08 00:00:00
abstract：:The effect of the N-methyl-D-aspartate (NMDA) receptor antagonist, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), on the ethanol-evoked release of brain ascorbate (AA) was investigated in freely moving rats using an in vivo voltammetry technique. Ethanol (1.0 g/kg, intraperitoneal injection, i.p.) increase...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90655-5
更新日期：1993-07-09 00:00:00
abstract：:In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same subtype-specific manne...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.03.066
更新日期：2006-07-24 00:00:00
abstract：:Four new tactile areas in the cerebellar cortex (crus I, crus II, paramedian lobule and uvula) have recently been described in the rat. Ipsilateral orofacial regions are chiefly represented in these areas. Our study of trigeminocerebellar afferents to these areas using the HRP retrograde tracing technique shows that t...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(78)90015-0
更新日期：1978-11-01 00:00:00
abstract：:Hindlimb sensory deprivation is known to induce a decrease in the cortical representation of hindpaw, and an increase in the size of the cutaneous receptive fields. The aim of the present study was to determine (i) the time-course of recovery when the rat retrieves a normal use of its limbs after a 14-day period of se...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02050-x
更新日期：2001-08-24 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) is produced both in the central nervous system (CNS) and the periphery. Effective in ameliorating neurodegeneration in several animal models of CNS disease, its promise as a therapeutic agent would be greatly enhanced if it readily crossed the blood-brain barrier (BBB...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00007-7
更新日期：2003-04-17 00:00:00
abstract：:Expression levels of amyloid beta (Abeta)-degrading enzymes, insulin degrading enzyme (IDE) and neprilysin (NEP), were examined in transgenic mice with Alzheimer's disease-like neuropathology. After the development of first Abeta plaques in transgenic mice brain, cortical mRNA and protein levels of IDE were significan...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.04.025
更新日期：2008-06-20 00:00:00
abstract：:Molecular forms of butyrylcholinesterase (BuChE) were studied in microvessels isolated from rat brain, using sedimentation analysis in sucrose gradients. Three forms, G1, G2 and G4, were found with sedimentation coefficients close to 3S, 6S and 9S, respectively. The relative proportion of the 3 forms was 19% for the m...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90164-5
更新日期：1990-11-27 00:00:00
abstract：:Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. Recently, it is demonstrated to have potent antinociceptive effect. However, little is understood about the mechanism underlying CGA analgesia. Here, we have found that CGA can exert an inhibitory effect on the functional activi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.03.027
更新日期：2014-05-01 00:00:00
abstract：:Quantitative in vitro receptor autoradiography was used to examine the effect of acute scopolamine administration on specific binding to components of the N-methyl-D-aspartate (NMDA) receptor complex in four regions of mouse hippocampus. The binding of [3H]glycine to the strychnine-insensitive site was increased 1 h a...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90264-a
更新日期：1990-10-02 00:00:00
abstract：:This study examined the effects of anterior pretectal nucleus (APT) conditioning stimulation on the activity of 92 functionally identified somatosensory brainstem neurons in the trigeminal (V) subnuclei oralis, interpolaris and caudalis of anesthetized rats. Conditioning stimulation inhibited most of the nociceptive n...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90524-b
更新日期：1992-01-06 00:00:00
abstract：:This study evaluates the potential neuroprotective properties of amburoside A, a glucoside isolated from Amburana cearensis, on rat mesencephalic cell cultures exposure to the neurotoxin 6-hydroxydopamine (6-OHDA). The parameters determined were cell viability by the 3[4,5-dimethylthiazole-2-il]-2,5-diphenyltetrazoliu...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.06.034
更新日期：2005-11-11 00:00:00
abstract：:Hearing loss is a common sensory disorder that affects more than 360 million people worldwide, and is primarily caused by the loss of hair cells (HCs). Ototoxic drugs, viral infections, genetic predisposition, aging or noise all damage HCs. 3β-hydroxysteroid-Δ24 reductase (DHCR24), one enzyme in the cholesterol biosyn...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.05.019
更新日期：2019-07-27 00:00:00
abstract：:The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit phosphorylation at serine 845 (GluR1-Ser845) by protein kinase G (PKG) activation was investigated in the nucleus accumbens (NAc) after repeated cocaine administration. Intra-NAc injection of the cyclic guanosine monop...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.04.003
更新日期：2013-06-07 00:00:00
abstract：:Depression is among the leading causes of disability and disease burden. Recent studies point to an involvement of altered serotonin1A receptor (5-HT1AR) -mediated adult neurogenesis in depression. However, the exact underlying mechanisms remain unclear, mainly due to the complexity of the serotonergic system with its...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.09.051
更新日期：2016-10-28 00:00:00
abstract：:Bay K 8644, nimodipine and omega-conotoxin GVIA (omega-CgTx) were used to study the different contribution of voltage-sensitive calcium channels (VSCC) to [3H]acetylcholine ([[3H]ACh) release in rat hippocampal synaptosomes. In our experimental conditions, the percentage of calcium-dependent ACh release was approximat...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90779-x
更新日期：1994-12-05 00:00:00
abstract：:The blood-brain barrier (BBB) plays an important role in controlling the passage of molecules from the blood to the extracellular fluid environment of the brain. An immortalised rat brain endothelial cell line (GPNT) was used to investigate the mechanisms underlying dexamethasone-induced decrease in paracellular perme...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(03)00348-3
更新日期：2003-06-26 00:00:00
abstract：:Autosomal-dominant familial amyotrophic lateral sclerosis (FALS) is associated with mutation in the gene that encodes Cu/Zn superoxide dismutase (SOD1). We identified a novel missense mutation of SOD-1 (Cys6Gly) in exon 1 in a Japanese woman and her family. The illness showed rapid progression similarly to the FALS wi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00803-4
更新日期：1999-12-03 00:00:00
abstract：:The nicotinic acetylcholine channel blockers mecamylamine (MECA) and pempidine (PEMP) blocked voltage-clamped isolated catfish retina cone horizontal responses to aspartate (Asp) and N-methyl-D-aspartate (NMDA) but had little effect on currents induced by kainate and quisqualate. Concentration response curves for NMDA...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90276-5
更新日期：1988-11-22 00:00:00
abstract：:Growth associated protein-43 (GAP-43) gene induction may be involved in reactive events that follow cerebral ischemic damage. Antagonists of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors are thought to ameliorate functional outcome after ischemic injury. To assess whether glutamate NMDA receptor bloc...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01833-x
更新日期：2001-06-08 00:00:00
abstract：:The purpose of the present experiment was to investigate the effect of vision on postural control following a lower limbs muscular fatigue. Ten adult males were asked to maintain a single leg upright posture as immobile as possible in two conditions of no-fatigue and fatigue of the calf muscles. This muscles fatigue w...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01987-5
更新日期：2001-08-03 00:00:00
abstract：:The role of oropharyngeal mechanisms in body water regulation was studied in 12 human males by measuring urine output and osmolality before and after drinking a very small volume of distilled water (0.15 ml/kg b.w.t.). Hypotonic diuresis was resulted only in the subjects (n = 6) who drank only sufficient water to keep...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90792-1
更新日期：1989-12-15 00:00:00
abstract：:Vlgr1 (very large G-protein coupled receptor 1) knockout mice against hybrid backgrounds of the 129/Ola and C57BL/6 mouse strains show hearing deficit and high susceptibility to audiogenic seizures. The present study examined how hearing impairment and susceptibility to audiogenic seizures in Vlgr1-deficient mice chan...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.06.012
更新日期：2009-09-18 00:00:00
abstract：:We evaluated the modulation of baroreceptor reflex (BRR) response by locus coeruleus (LC) in adult, male Sprague-Dawley rats anesthetized with urethane (1.5 g/kg, i.p.). Under an electrical stimulation condition that did not appreciably alter the basal systemic arterial pressure and heart rate, the LC significantly su...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90755-v
更新日期：1992-09-14 00:00:00
abstract：:The forebrain is one of the important suprapontine micturition centres. Previous studies have shown that electrical stimulation of the frontal lobe and the anterior cingulate gyrus elicited either inhibition or facilitation of bladder contraction. Patients with frontal lobe tumours and aneurysms showed micturition dis...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.02.015
更新日期：2010-03-31 00:00:00
abstract：:APPsw transgenic mice showing substantial features of brain Abeta amyloidosis such as senile plaques and behavioral abnormalities were examined by immunostaining to determine whether Abeta deposits could induce the subsequent disturbance of neurotransmitter systems including somatostatin, substance P and choline acety...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01443-9
更新日期：2000-10-13 00:00:00
abstract：:Chronic stress is well known to exacerbate pain. We tested the hypothesis that neonatal handling, which induces resilience to the negative impact of stress by increasing the quality and quantity of maternal care, attenuates the mechanical hyperalgesia produced by water-avoidance stress in the adult rat. Neonatal male ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.01.066
更新日期：2015-03-30 00:00:00
abstract：:The objective of the present study was to determine differences in neural networks between expert and novice archers during an archery pre-performance routine period (PPR). The experiment was conducted with eight world-class competitor or Olympic medalist archers and eight novices. In the experiment, the task was to s...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.09.018
更新日期：2008-11-21 00:00:00
abstract：:Approximately 8.5% of the unmyelinated and 2.5% of the myelinated primary afferent axons in lumbar dorsal roots of normal rats are immunostained for glutamate. Thus unmyelinated fibers are the predominantly immunostained population under the conditions of our experiments. The mean size of the unmyelinated fibers is gr...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90235-8
更新日期：1989-01-02 00:00:00
