Abstract:
:In the present study we sought to investigate the signal transduction mechanisms that underlie the alpha2-adrenergic receptor (AR)-induced, subtype-specific neuronal differentiation of PC12 cells. Alpha2-ARs induced NF-kappaB transcriptional activity and p21(waf-1) gene transcription in the same subtype-specific manner (alpha2A journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
abstract::This study used ERPs to determine whether older adults use prosody in resolving early and late closure ambiguities comparably to young adults. Participants made off-line acceptability judgments on well-formed sentences or those containing prosody-syntax mismatches. Behaviorally, both groups identified mismatches, but ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.01.072
更新日期:2010-03-19 00:00:00
abstract::Distributions of one sensory and 13 motor axons to intrafusal fibers in a human spindle from the biceps brachii muscle were reconstructed from serial, 1 micron thick transverse sections. The primary afferent was distributed predominantly to nuclear bag fibers. Motor innervation in the human spindle was characterized b...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90058-3
更新日期:1986-01-16 00:00:00
abstract::Nitric oxide, an endogenous gas produced by nitric oxide synthase (NOS), has been described as a neuromodulator of hormone secretion, including the neurohypophysial peptides oxytocin (OT) and vasopressin (AVP), hormones involved in the sodium and water homeostasis. The presence of NOS in the hypothalamic nuclei as wel...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.12.032
更新日期:2005-05-06 00:00:00
abstract::Stereotaxic microinjection of herpes simplex virus (HSV) into the mouse olfactory bulb resulted in infection of neurons of the piriform cortex. Neurons infected with the wildtype HSV showed no evident phosphorylation of c-Jun N-terminal protein kinase (JNK)/c-Jun. In contrast, neurons infected with a US3 gene-disrupte...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.08.033
更新日期:2003-11-20 00:00:00
abstract::Accumulating evidences have pointed out that neuroinflammation is involved in Parkinson's disease (PD) pathogenesis. Toll-like receptor 3 (TLR3), as a member of pattern-recognition receptors (PRRs), is known to play a pivotal role in inflammatory responses and immune responses. It was recently suggested that TLR3 was ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135005
更新日期:2020-05-29 00:00:00
abstract::The psychophysiological basis of problem size effect in the arithmetical processing of additions and subtractions was studied with event-related brain potentials (ERP). Subjects were presented sequences of seven numbers, and ERPs elicited to the sixth number were analyzed. Two variables were manipulated: operation typ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.09.053
更新日期:2005-01-03 00:00:00
abstract::The present study confirmed histopathologically the suggestion that pulmonary edema may underlie the fulminant death following microinjection of kainic acid into many medullary sites in rats anesthetized with pentobarbital sodium. We also observed a sustained elevation in systemic arterial pressure, cardiac contractil...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90572-5
更新日期:1985-12-18 00:00:00
abstract::An increase in the arthritis index as a marker of chronic inflammation and suppression of food intake are observed in adjuvant arthritic (AA) rats. Our previous study demonstrated that central oxytocin (OXT)-ergic pathways were activated potently in AA rats. In the present study, OXT-saporin (SAP) cytotoxin, which che...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.04.010
更新日期:2016-05-16 00:00:00
abstract::The purpose of this study was to investigate how the recruitment gain, as derived from the Hoffmann (H)-reflex measurement, of antagonistic motoneurons is modulated during voluntary lengthening (LEN) and shortening (SHO) contractions in the human tibialis anterior (TA) muscle. To this end, the parameters of the ratios...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00241-6
更新日期:2003-05-15 00:00:00
abstract::Bax, a pro-apoptotic member of Bcl-2 family proteins, plays a central role in mitochondria-dependent apoptosis. Bax normally resides in the cytosol in a quiescent state. Bax-inhibiting peptide (BIP) is a membrane permeable peptide comprised of five amino acids designed from the Bax-binding domain of Ku70 [M. Sawada, P...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.08.075
更新日期:2004-11-30 00:00:00
abstract::Diffusion MRI studies characterizing the changes in white matter (WM) due to vascular cognitive impairment, which includes all forms of small vessel disease are reviewed. We reviewed the usefulness of diffusion methods in discriminating the affected WM regions and its relation to cognitive impairment. These studies we...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2018.12.007
更新日期:2019-02-16 00:00:00
abstract::Application of NMDA, or agents releasing nitric oxide (NO), onto the dendrites of hippocampal granule cells increased the levels of the mRNA encoding MAP2, a cytoskeletal component induced during periods of neurite outgrowth. Furthermore, local increases in the hybridisation signal in the molecular layer, representing...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90031-0
更新日期:1994-08-15 00:00:00
abstract::The association between insulin degrading enzyme (IDE) gene polymorphisms and Alzheimer's disease (AD) risk has been widely reported, but results were somewhat controversial. To assess the association between IDE polymorphisms and AD risk, a meta-analysis was performed. We systematically reviewed relevant studies retr...
journal_title:Neuroscience letters
pub_type: 杂志文章,meta分析
doi:10.1016/j.neulet.2013.01.051
更新日期:2013-04-29 00:00:00
abstract::To determine how target-derived nerve growth factor (NGF) affects sensory neuronal survival and the development of topographic nerve projections in the spinal cord, anatomical studies were performed on transgenic mice that overexpress NGF in skin and other keratinized epithelial structures. Transgenic animals showed a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12641-0
更新日期:1996-06-14 00:00:00
abstract::An antiserum to choline acetyltransferase, partially purified from bovine brain (anti-ChAT 1), when incubated with synaptosomes prepared from rat cerebral cortex in the presence of complement caused release of 10% of lactate dehydrogenase and 27% of ChAT. Sodium-dependent uptake of choline was totally abolished. Simil...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90469-6
更新日期:1986-10-08 00:00:00
abstract::Although the main source of circulating ghrelin is the stomach, it is also present in physiologically relevant amounts in the hypothalamus. It is reported that pharmacological doses of melatonin decrease blood levels of ghrelin. Thus, melatonin (MT) may be a candidate for the regulation of ghrelin synthesis in the bra...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.09.071
更新日期:2006-12-20 00:00:00
abstract::Lithium has been successfully employed therapeutically for treatment of bipolar depressive illness; however, its mechanism of action is poorly understood. Recently, it has been demonstrated by us that lithium can prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) dopaminergic neurotoxicity in mice. From analy...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.03.055
更新日期:2012-05-10 00:00:00
abstract::Suicide is a major contributor to the morbidity and mortality of schizophrenia, accounting for approximately 10% of deaths in these patients. Genetic factors have been reported to modulate the risk for suicide, although the precise mechanism and magnitude of the genetic contribution are unknown. Further, suicide attem...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.11.079
更新日期:2011-02-11 00:00:00
abstract::Using a training protocol that effectively induces procedural memory consolidation (PMC) in young adults, we show that older adults are good learners, robustly improving their motor performance during training. However, performance declined over the day, and overnight 'offline' consolidation phase performance gains we...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.08.051
更新日期:2015-10-08 00:00:00
abstract::We examined age effects on Movement related potentials (MRPs) in 13 young (mean age = 29.3 years) and 13 old (mean age = 67.2 years) normal adults in right, left and bimanual self-paced button press conditions. Both the groups generated a slowly rising readiness potential (RP) at about 1000 ms, a negative shift (NS') ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(90)90747-w
更新日期:1990-10-30 00:00:00
abstract::Excess cholesterol is removed from the brain via hydroxylation mediated by cholesterol 24S-hydroxylase (CYP46). Although serum and cerebrospinal fluid (CSF) concentrations of 24S-hydroxycholesterol are altered during the progress of Alzheimer's disease, studies carried out to date in different populations on the assoc...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.03.049
更新日期:2005-07-22 00:00:00
abstract::We have previously reported that there is an up-regulation of the NR2B gene expression in the adult cortex and cultured fetal cortical neurons of mice following chronic ethanol treatment due to demethylation of cytosine residues in the NR2B gene CpG island. In the present study, we investigated the methylation pattern...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.01.042
更新日期:2005-06-03 00:00:00
abstract::Traumatic brain injury is associated with behavioral deficits, often in the absence of histopathological or ultrastructural changes. To determine whether membrane remodeling occurs, immunocytochemical techniques were used and the density and distribution of GAP-43 were measured. GAP-43 is a membrane-bound protein, whi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00712-5
更新日期:1998-10-16 00:00:00
abstract::The displaced retinal ganglion cells in normal rats and rats with left eye enucleated at birth were studied using the fluorescent dye Fast blue as neuronal marker. The dye was introduced to the right optic tract of the rats 7 days before perfusion. Frozen coronal sections of the brains and retinal whole-mounts from al...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90315-0
更新日期:1986-06-30 00:00:00
abstract::Against the current concept of abortive regeneration of axotomized neurons in the mammalian central nervous system, the occurrence of remarkable axonal regeneration of cerebellothalamic projection neurons following transection of the decussation of the superior cerebellar peduncle was proved in kittens morphologically...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90093-8
更新日期:1981-08-07 00:00:00
abstract::In the present experiments it was tested whether the organic calcium antagonist verapamil has an influence on N-methyl-D-aspartate (NMDA) induced cortical field potentials (CFP) in neocortical slices of guinea pigs. NMDA (1 mumol/l) was applied via a micropipette by pressure pulses. Verapamil (60 mumol/l) was administ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90288-v
更新日期:1993-10-29 00:00:00
abstract::In an attempt to understand the changes of circulating neuropeptide Y (NPY) during hypoxia, the plasma level of NPY was investigated by radioimmunoassay. Exposure of rats to hypobaric hypoxia at an altitude of 18,000 ft for 4 weeks causes an increase of pulmonary pressure and an elevation of plasma NPY-like immunoreac...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90105-g
更新日期:1992-06-22 00:00:00
abstract::Monotherapy with antibodies to tumor necrosis factor-alpha (TNF) or interleukin-1 receptor 1 (IL-1R1) reduces hyperalgesia in an animal model of painful neuropathy. Here we investigated whether combined therapy with epineurial anti-TNF and anti-IL-1R1 antibodies produces a further advantage. C57BL/6 mice with a chroni...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02077-8
更新日期:2001-09-14 00:00:00
abstract::We examined the effects of ibotenic acid induced unilateral lesion of the nucleus basalis magnocellularis (nBM) on carbachol- and serotonin-stimulated phosphoinositide (PI) breakdown in miniprisms obtained from rat fronto-parietal cortex 1 week following the lesion. Lesion-side muscarinic and serotoninergic receptor r...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11658-j
更新日期:1995-06-23 00:00:00
abstract::To better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60kDa, in the ischemic brain, we investigated the time course and regional distribution of active Src expression by using a specific antibody against Tyr416 phosphorylated Src (phospho-Src) in the rat hippocampus...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.01.015
更新日期:2005-05-20 00:00:00