Abstract：
:We evaluated the modulation of baroreceptor reflex (BRR) response by locus coeruleus (LC) in adult, male Sprague-Dawley rats anesthetized with urethane (1.5 g/kg, i.p.). Under an electrical stimulation condition that did not appreciably alter the basal systemic arterial pressure and heart rate, the LC significantly suppressed the BRR response. Microinjection of L-glutamate (1 nmol, 50 nl) into the LC essentially duplicated this depressant effect. Intracerebroventricular (i.c.v.) administration of the alpha 1-adrenoceptor antagonist, prazosin (6.5 nmol), appreciably blunted the inhibition by LC on the BRR response. Yohimbine (6.5 nmol), the alpha 2-adrenoceptor blocker, however, was ineffective. Direct microinjection of prazosin (50 pmol), but not yohimbine (50 pmol), into the terminal site of baroreceptor afferents at the nucleus tractus solitarii (NTS) also significantly blunted the suppressive effect of LC on the BRR response. These results suggest that the LC may produce an inhibition on the BRR response by a process that involves the alpha 1-adrenoceptors located in the NTS.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chan JY,Jang SF,Chan SHdoi
10.1016/0304-3940(92)90755-vkeywords:
subject
Has Abstractpub_date
1992-09-14 00:00:00pages
225-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(92)90755-Vjournal_volume
144pub_type
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