Abstract:
:Transition of the cellular responsiveness to a cholinergic stimulation during a prolonged stimulation with acetylcholine (ACh) of adrenal chromaffin cells was studied by directly monitoring the secretory process in cell bed perfusion experiments. A pulsatile injection of hexamethonium during the prolonged stimulation caused an interruption of the response. Step-up of the ACh concentration in the declining phase of the primary response evoked an additional response. The magnitude of the response to the step-up was reduced by extracellular Ca2+ in a dose-dependent manner. However, neither the peak amplitude nor the declining rate of the primary response was affected by Ca2+ in such a direction. These results suggest that the transient nature of the ACh-evoked response is mainly attributable to the inactivation of transduction mechanisms between receptor stimulation and channel activation. Although Ca2+-facilitated desensitization of nicotinic receptors is in process during the stimulation, such a desensitization may account only insignificantly for the transient nature.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ohara-Imaizumi M,Kumakura Kdoi
10.1016/0304-3940(86)90472-6subject
Has Abstractpub_date
1986-10-08 00:00:00pages
250-4issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(86)90472-6journal_volume
70pub_type
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