Abstract:
:Reciprocal Ia inhibition from ankle flexors to extensors was studied in five patients with spasticity due to incomplete traumatic spinal cord lesions. Nine healthy subjects were tested as controls. Excitability of the soleus motoneuron pool was estimated by H-reflex testing in the resting state. Ia inhibition was activated by conditioning stimuli to the peroneal nerve. Ia inhibition was detected in all patients tested, the amount of inhibition ranging from 8% to more than 50% of the test H-reflex size. In the control subjects only weak Ia inhibitory effects were present. These findings indicate increased excitability of the Ia inhibitory pathway to ankle extensor motoneurons in patients with spasticity due to spinal cord injury.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Boorman G,Hulliger M,Lee RG,Tako K,Tanaka Rdoi
10.1016/0304-3940(91)90894-ysubject
Has Abstractpub_date
1991-06-10 00:00:00pages
57-60issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(91)90894-Yjournal_volume
127pub_type
杂志文章abstract::The activities of monoamine oxidase (MAO)-A and -B in subcellular fractions of bovine retina were determined using serotonin and beta-phenylethylamine, respectively, as substrates. The subcellular fractions were a P1 fraction containing photoreceptor cell synaptosomes and a P2 fraction enriched with small synaptosomes...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90382-7
更新日期:1981-01-20 00:00:00
abstract::The Gallyas-Braak silver impregnation method revealed neurons containing well-defined intraneuronal granules in both Alzheimer's disease and normal control brains. The granules were immunostained prominently with the Alz-50 antibody and, to a lesser degree, with the tau-2 antibody, but not with other anti-tau antibodi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00867-2
更新日期:1998-12-18 00:00:00
abstract::In a classic demonstration, Ernst Mach showed that the same figure could be perceived as a square or as a diamond depending on the orientation of the subject relative to gravity. Such phenomenon is based on the use of a geocentric reference frame for object perception. If the central nervous system perceives an object...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.10.012
更新日期:2008-12-12 00:00:00
abstract::Two types of mRNAs for neurofibromin isoforms, which are produced by Von Recklinghausen neurofibromatosis (NF1) gene, have so far been identified. In the present study, we analyzed the differential expression of the two NF1 mRNAs in 16 cases of human astrocytic tumors and in surrounding normal tissues by the RNA-polym...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11875-w
更新日期:1995-08-25 00:00:00
abstract::We developed a novel procedure for efficient mutagenesis of zebrafish using a DNA cross-linking agent 4,5',8-trimethylpsoralen (TMP), which is known to frequently induce small deletions in Escherichia coli and Caenorhabditis elegans. A specific-locus test and pilot screenings indicated that the TMP mutagenesis procedu...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)00132-3
更新日期:1998-03-13 00:00:00
abstract::Several studies have shown that blockade of colony stimulating factor-1 (CSF-1) or its receptor (CSF-1R) inhibits disease progression in rodent models of rheumatoid arthritis (RA); however, the role of the CSF-1/CSF-1R pathway in RA-induced pain and functional deficits has not been studied. Thus, we examined the effec...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.09.053
更新日期:2015-01-01 00:00:00
abstract::In brainstem slices of guinea pigs perfused with artificial cerebro-spinal fluid (ACSF), the discharge of all the spontaneously active neurons of the medial vestibular nucleus (MVN) is regular. It has been reported that prolonged exposure to a low Ca(2+) medium could induce these neurons to fire bursts of spikes. In t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01677-3
更新日期:2001-01-12 00:00:00
abstract::Effects of cortisol on 22 tuberoinfundibular (TI) neurons in the paraventricular nucleus (PVN) of the hypothalamus were examined in urethane-anesthetized rats. Iontophoretically applied cortisol excited 10 (45%) of 22 TI-neurons tested, whereas the cortisol inhibited 4 (31%) of 13 neurons in the periventricular hypoth...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90141-3
更新日期:1988-04-22 00:00:00
abstract::Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90221-7
更新日期:1987-12-16 00:00:00
abstract::The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic and uric acid were measured in rat brain in vivo using microdialysis coupled to HPLC with ultra violet spectrophotometry. Treatment with kainic acid at pH 4.1 (50 nmol) caused a significant increase in ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)12073-d
更新日期:1995-11-10 00:00:00
abstract::The injection of oxytocin into the third ventricle during suckling in lactating rats not only enhances neurosecretory bursts but also the background activity of oxytocin cells. However, removing the young rats 10 min after the oxytocin injection is immediately followed by a decrease in background activity, while injec...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90079-6
更新日期:1987-03-20 00:00:00
abstract::Partial depolarization of primary cerebellar neuronal cultures with K+ evoked the release of aspartate, glutamate, adenosine, serine, taurine, gamma-aminobutyric acid (GABA), alanine and proline. The dihydropyridine calcium channel agonist, BAY K 8644, significantly augmented the K+-induced release of adenosine, aspar...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90314-5
更新日期:1989-07-17 00:00:00
abstract::N-Acetylaspartylglutamate (NAAG) is a dipeptide, and has been demonstrated to be a putative neurotransmitter in the brain. We hereby report the toxicity of NAAG in sagittal slices of mouse brain, in vitro, which is prevented by both N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists. Incubation of mouse bra...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90368-4
更新日期:1991-05-13 00:00:00
abstract::This study examined the ERP (event-related potential) correlates of categorization processing in brand extension with irrelative task. Participants faced two sequential stimuli in a pair consisting of a soft drink brand name (S1) and a product name (S2) which comprised two categories: beverage (typical product of the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.07.043
更新日期:2012-09-06 00:00:00
abstract::Event-related potentials were recorded from sleeping newborns to compare amplitudes and latencies of mismatch negativity (MMN) and late discriminative negativity (LDN) in active and quiet sleep stages. MMN and LDN were obtained in response to changes in semi-synthesized vowels from 20 healthy newborn infants. MMN and ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)01401-5
更新日期:2003-04-10 00:00:00
abstract::Novel paired ependymal ridges (EPRS) have been identified in the ventrolateral wall of the cerebral aqueduct of the rat. Scanning electron microscopic techniques revealed that the dorsolateral and ventromedial ridges differ from each other in surface morphology. Using the PAP immunohistochemical technique, the EPRS de...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(81)90196-8
更新日期:1981-11-18 00:00:00
abstract::The levels of apoptosis associated proteins Bcl(2), Bax, cytochrome-c and p53 was investigated in mice cerebral cortex and cerebellum, using an experimental model of fatal murine cerebral malaria (FMCM). Owing to the activation of events central to mitochondrial dysfunctions, we monitored the structural integrity of m...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00470-6
更新日期:2002-09-06 00:00:00
abstract::A seizure disorder, characterized by sporadic tonic/clonic seizures has been identified in a strain of mice carrying the weaver (wv) gene. Breeding studies and a review of the literature indicate that this is either a property of the wv gene or linked to it tightly. ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90052-9
更新日期:1989-01-16 00:00:00
abstract::The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene has been reported to be a candidate gene for susceptibility to Parkinson's disease (PD), but results of different studies are conflicting. Here, we conducted a meta-analysis of published case-control studies to evaluate the association between MTHFR C677T and A...
journal_title:Neuroscience letters
pub_type: 杂志文章,meta分析
doi:10.1016/j.neulet.2017.10.060
更新日期:2018-01-01 00:00:00
abstract::Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and hav...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2019.134326
更新日期:2019-09-14 00:00:00
abstract::Activation of the μ-opioid receptor (MOR) and noradrenaline reuptake inhibition (NRI) are well recognized as analgesic principles in acute and chronic pain indications. The novel analgesic tapentadol combines MOR agonism and NRI in a single molecule. The present study used OPRM1 (MOR) knockout (KO) mice to determine t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.01.014
更新日期:2011-03-17 00:00:00
abstract::Infection of the snail Lymnaea stagnalis with the schistosome parasite Trichobilharzia ocellata results in inhibition of reproduction and in giant growth. Parasite-related effects on the neuroendocrine centres that control these processes were studied electrophysiologically. Haemolymph from infected snails reduced the...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90047-b
更新日期:1992-03-02 00:00:00
abstract::In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological p...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00315-x
更新日期:2003-05-29 00:00:00
abstract::Surround inhibition (SI) is a neural mechanism to focus neuronal activity and facilitate selective motor execution (ME). The aim of the present study was to investigate whether SI is also generated during motor imagery (MI). Furthermore, we investigated whether the extent of SI during MI depends on the strength of SI ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.07.012
更新日期:2016-08-26 00:00:00
abstract::Neuronal nAChRs are pentameric transmembrane proteins which function as ligand-gated ion channels and are composed of multiple alpha and beta subunits. Nine neuronal nAChR alpha subunit genes (alpha2-alpha10) and three nAChR beta subunit genes (beta2-beta4) have been identified. nAChR subtypes are heteromers, composed...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.02.067
更新日期:2006-05-29 00:00:00
abstract::The presence of a novel member of serine proteinase inhibitor, B-43, was immunohistochemically indicated in both neurons and astrocytes in the parietal region of the bovine brain. B-43-like immunoreactivity was detected in pyramidal cells in the cortex and GFAP-positive astroglial cells in the white matter. The proces...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)12095-l
更新日期:1995-11-17 00:00:00
abstract::Chronic increases in spontaneous multiunit activity can be induced in the dorsal cochlear nucleus (DCN) of hamsters by intense sound exposure (Kaltenbach and McCaslin, 1996). It has been hypothesized that this hyperactivity may represent a neural code that could underlie the sound percepts of tinnitus. The goal of the...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2003.10.038
更新日期:2004-01-23 00:00:00
abstract::Whole-cell and single channel recordings were used to characterize an intermediate conductance calcium-activated potassium (KCa) channel in sensory neurons of the nodose ganglion. From a -80 mV holding potential, the total outward current in these neurons was increased when extracellular calcium was raised from 0.02 t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)91056-1
更新日期:1994-02-14 00:00:00
abstract::MicroRNAs (miRNAs) are small noncoding RNAs that function as tumor suppressors or oncogenes. MicroRNA-107 (miR-107), a transcriptional target of p53, is deregulated in many cancer cell lines. Here, we showed that miR-107 is down-regulated in glioma tissues and cell lines, in particular, p53-mutated U251 and A172. Tran...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.11.047
更新日期:2013-02-08 00:00:00
abstract::Nerve growth factor (NGF) protein has been implicated in alterations of cognitive function either following brain damage, selective lesions or aging. Groups of rats were given long-term (48 weeks) oral barbital treatment or tap water and following an extended period of abstinence (14 weeks) were tested for spatial lea...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90299-m
更新日期:1992-03-16 00:00:00