Detection of the lipid peroxidation product malonaldehyde in rat brain in vivo.


:The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic and uric acid were measured in rat brain in vivo using microdialysis coupled to HPLC with ultra violet spectrophotometry. Treatment with kainic acid at pH 4.1 (50 nmol) caused a significant increase in the sampled concentration of MDA but no significant changes in the antioxidants. Treatment with the same dose of kainic acid at pH 7.2 did not cause a significant increase in MDA, although some changes were noted in the antioxidants. The paper demonstrates the ability to monitor changes of a lipid peroxidation breakdown product as a measure of oxidative stress in vivo. Furthermore, the data suggests that the toxic action of kainic acid in acute preparations may be due to the elevation of hydrogen ions.


Neurosci Lett


Neuroscience letters


Waterfall AH,Singh G,Fry JR,Marsden CA




Has Abstract


1995-11-10 00:00:00














  • Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis.

    abstract::Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that inhibition of complement activation attenuates disease development in the CNS, the specific complement components that contribute to the pathogenesis of CNS dis...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Reiman R,Campos Torres A,Martin BK,Ting JP,Campbell IL,Barnum SR

    更新日期:2005-12-30 00:00:00

  • Localization of melatonin binding sites in the pars tuberalis of the mink at three times during the seasonal testicular cycle.

    abstract::The strict photoperiodic dependence of gonadotropic function observed in mink provides an excellent physiological model for studying the activity of GnRH hypothalamic neurons. In mink, exposure to more than 10 h light inhibits the activity of this neurohormonal system. Melatonin plays an essential role in this type of...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Boissin-Agasse L,Barberis C,Audigier S,Roch G,Boissin J

    更新日期:1992-09-14 00:00:00

  • Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model.

    abstract::Parkin is a ubiquitin ligase involved in the ubiquitin-proteasome system. Elevating parkin expression in cells reduces markers of oxidative stress while blocking parkin expression increases oxidative stress. In parkin gene knock down mouse and fly models, mitochondria function is deficient. Parkin is neuroprotective a...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Klein RL,Dayton RD,Henderson KM,Petrucelli L

    更新日期:2006-06-19 00:00:00

  • The mismatch negativity component reveals the sensory memory during REM sleep in humans.

    abstract::Auditory evoked potentials (AEPs) were recorded during presentation of stimuli of 1000 Hz (standard) and 2000 Hz (deviant) in trains of 10 tone bursts (one deviant per train) in the wake and rapid eye movement (REM) sleep states. The constant inter-stimulus interval (ISI) was 600 ms and the trains were separated by 3 ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Atienza M,Cantero JL,Gómez CM

    更新日期:1997-11-14 00:00:00

  • Identification of macrophage migration inhibitory factor mRNA expression in neural cells of the rat brain by in situ hybridization.

    abstract::Macrophage migration inhibitory factor (MIF) has been rediscovered as a hormone and immunomodulator as well as a proinflammatory cytokine. We investigated the expression of MIF protein and mRNA in the rat brain using optimized immunohistochemistry and in situ hybridization, respectively. By immunohistochemical analysi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ogata A,Nishihira J,Suzuki T,Nagashima K,Tashiro K

    更新日期:1998-05-01 00:00:00

  • Different binding pattern of antibodies to prion protein on lymphocytes from patients with sporadic Creutzfeldt-Jakob disease.

    abstract::In Creutzfeldt-Jakob disease (CJD), progressive neuronal cell death probably occurs as a result of a change in conformation of the physiological prion protein (PrP(C)). There is evidence of participation of the lymphatic system and in particular of lymphocytes in the intracorporeal transportation of the pathological p...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ratzka P,Döhlinger S,Cepek L,Steinacker P,Arlt S,Jacobi C,Schröter A,Wiltfang J,Prange H,Kretzschmar HA,Poser S,Otto M

    更新日期:2003-05-29 00:00:00

  • Early rapid rise in EAAT2 expression follows the period of maximal seizure susceptibility in human brain.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lauriat TL,Schmeidler J,McInnes LA

    更新日期:2007-01-22 00:00:00

  • Adaptation to audiotactile asynchrony.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Navarra J,Soto-Faraco S,Spence C

    更新日期:2007-02-08 00:00:00

  • Effect of sertindole on QTc interval in patients with schizophrenia.

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    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章


    authors: Atmaca M,Yavuzkir M,Mermi O,Topuz M,Kanmaz E,Tezcan E

    更新日期:2008-09-05 00:00:00

  • Is light receptor a dipole? Electrophysiological study in an arachnid.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ramakrishna T

    更新日期:1977-06-01 00:00:00

  • Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Hüll M,Eistetter J,Fiebich BL,Bauer J

    更新日期:1999-02-12 00:00:00

  • Adrenergic neurons in sheep brain demonstrated by immunohistochemistry with antibodies to phenylethanolamine N-methyltransferase (PNMT) and dopamine-beta-hydroxylase (DBH): absence of the C1 cell group in the sheep brain.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Tillet Y

    更新日期:1988-12-19 00:00:00

  • Human mesenchymal stem cells improve the neurodegeneration of femoral nerve in a diabetic foot ulceration rats.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Xia N,Xu JM,Zhao N,Zhao QS,Li M,Cheng ZF

    更新日期:2015-06-15 00:00:00

  • Serotonin inhibits GABA synaptic transmission in presympathetic paraventricular nucleus neurons.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lee KS,Han TH,Jo JY,Kang G,Lee SY,Ryu PD,Im JH,Jeon BH,Park JB

    更新日期:2008-07-11 00:00:00

  • Depletion of norepinephrine of the central nervous system Down-regulates the blood glucose level in d-glucose-fed and restraint stress models.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Park SH,Kim SS,Lee JR,Sharma N,Suh HW

    更新日期:2016-05-04 00:00:00

  • Functional studies of single-site variants in the calmodulin-binding domain of RC3/neurogranin in Xenopus oocytes.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Watson JB,Margulies JE,Coulter PM 2nd,Gerendasy DD,Sutcliffe JG,Cohen RW

    更新日期:1996-11-29 00:00:00

  • Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina.

    abstract::The nicotinic acetylcholine channel blockers mecamylamine (MECA) and pempidine (PEMP) blocked voltage-clamped isolated catfish retina cone horizontal responses to aspartate (Asp) and N-methyl-D-aspartate (NMDA) but had little effect on currents induced by kainate and quisqualate. Concentration response curves for NMDA...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: O'Dell TJ,Christensen BN

    更新日期:1988-11-22 00:00:00

  • Chronic exposure to random restraint stress retards the development of estrogen-induced pituitary prolactinoma in rats.

    abstract::The effects of stress on carcinogenesis have been equivocal. The present work examined the influence of an unpredictable pattern of chronic restraint stress on estradiol-induced pituitary hyperplasia in male Fischer 344 rats. The animals were grouped as follows: (1) control, (2) stressed, (3) estradiol (31 mg), subcut...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Gottesfeld Z,Liehr JG

    更新日期:1987-09-11 00:00:00

  • GABAρ expression in the medial nucleus of the trapezoid body.

    abstract::The Calyx of Held (CoH) synapse is the largest synapse in mammals. It is located in the medial nucleus of the trapezoid body (MNTB) and forms part of the auditory pathway. Modest GABAergic signaling is present in the CoH before hearing onset, when glutamatergic transmission predominates. In mice, after postnatal day 1...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Reyes-Haro D,Rosas-Arellano A,González-González MA,Mora-Loyola E,Miledi R,Martínez-Torres A

    更新日期:2013-01-04 00:00:00

  • mTOR activates hypoxia-inducible factor-1α and inhibits neuronal apoptosis in the developing rat brain during the early phase after hypoxia-ischemia.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Chen H,Xiong T,Qu Y,Zhao F,Ferriero D,Mu D

    更新日期:2012-01-24 00:00:00

  • Antipyretic effects of acupuncture on the lipopolysaccharide-induced fever and expression of interleukin-6 and interleukin-1 beta mRNAs in the hypothalamus of rats.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Son YS,Park HJ,Kwon OB,Jung SC,Shin HC,Lim S

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  • Electrophysiological properties of lemniscal afferents in rat after kainic acid lesions in the ventrobasal thalamus.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Peschanski M,Briand A,Poingt JP,Guilbaud G

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  • Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse hippocampus.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Koga S,Kojima A,Kuwabara S,Yoshiyama Y

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lindsay RM,Tarbit J

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Zhu CB,Cao XD,Xu SF,Wu GC

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Köchli S,Scharfenberger T,Dietz V

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lo MM,Niehoff DL,Kuhar MJ,Snyder SH

    更新日期:1983-08-19 00:00:00

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lambeng N,Grossmann M,Chatelain P,Fuks B

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