Detection of the lipid peroxidation product malonaldehyde in rat brain in vivo.

Abstract:

:The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic and uric acid were measured in rat brain in vivo using microdialysis coupled to HPLC with ultra violet spectrophotometry. Treatment with kainic acid at pH 4.1 (50 nmol) caused a significant increase in the sampled concentration of MDA but no significant changes in the antioxidants. Treatment with the same dose of kainic acid at pH 7.2 did not cause a significant increase in MDA, although some changes were noted in the antioxidants. The paper demonstrates the ability to monitor changes of a lipid peroxidation breakdown product as a measure of oxidative stress in vivo. Furthermore, the data suggests that the toxic action of kainic acid in acute preparations may be due to the elevation of hydrogen ions.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Waterfall AH,Singh G,Fry JR,Marsden CA

doi

10.1016/0304-3940(95)12073-d

subject

Has Abstract

pub_date

1995-11-10 00:00:00

pages

69-72

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)12073-D

journal_volume

200

pub_type

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