Gene editing based hearing impairment research and therapeutics.

abstract：:Noise-induced hearing loss (NIHL) has been thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. This study examined the effects of baicalin, baicalein, and Scutellaria baicalensis (SB) extract against NIHL in a mouse model. Mice received oral treatment w...

journal_title：Neuroscience letters

authors： Kang TH,Hong BN,Park C,Kim SY,Park R

更新日期：2010-01-29 00:00:00

abstract：:Estrogens (E2) derived from ovaries and/or local de novo synthesis in the hippocampus profoundly regulate hippocampal structure and function, but the importance of local E2 versus ovarian E2 on hippocampal synaptic plasticity and spatial memory has not been well elucidated. The present study used ovariectomy (OVX) and...

journal_title：Neuroscience letters

authors： Liu M,Xing F,Bian C,Zhao Y,Zhao J,Liu Y,Zhang J

更新日期：2019-07-27 00:00:00

abstract：:Recent evidence has been presented demonstrating that group III mechanoreceptors comprise an important part of the sensory arm of the exercise pressor reflex, which in turn functions to increase arterial blood flow to contracting skeletal muscles. Although group III afferents are stimulated by mechanical distortion of...

journal_title：Neuroscience letters

authors： Leal AK,Stone AJ,Yamauchi K,McCord JL,Kaufman MP

更新日期：2013-10-25 00:00:00

abstract：:Mesial temporal lobe epilepsy (MTLE) is a common type of intractable epilepsy characterized by astroglial gliosis. The S100B was viewed as an astrocyte marker and experimental studies indicated that S100B might be involved in the pathophysiology of temporal lobe epilepsy. In this study, we measured plasma S100B levels...

journal_title：Neuroscience letters

authors： Lu C,Li J,Sun W,Feng L,Li L,Liu A,Li J,Mao W,Wei H,Gao L,Zhang X,Huang Z,Meng X,Wang Y

更新日期：2010-10-29 00:00:00

abstract：:Responses of single neurones to vibrissal stimulation and to the iontophoretically applied putative neurotransmitters, L-glutamate and L-aspartate, were recorded in the trigeminal nucleus caudalis of the rat. Vibrissal responses were unaffected by the specific N-methyl-D-aspartate receptor antagonist, D-alpha-aminoadi...

journal_title：Neuroscience letters

authors： Salt TE,Hill RG

更新日期：1981-03-10 00:00:00

abstract：:Using a push-pull device, the release of endogenous proteins in the extracellular space was investigated in the CA1 region of the hippocampus of anaesthetized rats. With low-frequency stimulation of the Schaffer collaterals, there was a relatively stable release of 5 proteins (64, 54, 48, 45 and 16 kDa). A train of hi...

journal_title：Neuroscience letters

authors： Charriaut-Marlangue C,Aniksztejn L,Roisin MP,Ben-Ari Y

更新日期：1988-09-12 00:00:00

abstract：:In vitro quantitative autoradiography was used to visualize nicotinic receptors in large cryosections of human brain hemispheres. Sections 80 microns thick of human brain hemispheres were incubated with (-)-[3H]nicotine and the distribution of nicotinic receptors in human brain was studied. Increasing numbers of nicot...

journal_title：Neuroscience letters

authors： Adem A,Nordberg A,Jossan SS,Sara V,Gillberg PG

更新日期：1989-07-03 00:00:00

abstract：:The electrophysiological mechanism underlying afterhyperpolarization induced by the activation of the nicotinic acetylcholine receptor (nAChR) in male rat major pelvic ganglion neurons (MPG) was investigated using a gramicidin-perforated patch clamp and microscopic fluorescence measurement system. Acetylcholine (ACh) ...

journal_title：Neuroscience letters

authors： Park KS,Cha SK,Kim MJ,Kim NH,Lee JW,Jeong SW,Kong ID

更新日期：2010-09-27 00:00:00

abstract：:The projections of neurons, in and around the A1 noradrenergic cell group of the caudal ventrolateral medulla (VLM), to nucleus of the solitary tract (NTS) were studied in the cat using the anterograde transport of Phaseolus vulgaris leucoagglutinin (PHA-L). PHA-L was micro-iontophoresed into the region of the A1 nora...

journal_title：Neuroscience letters

authors： Roder S,Ciriello J

更新日期：1992-01-06 00:00:00

abstract：:To search for brain molecules that share epitopes with HIV (human immunodeficiency virus) proteins, we investigated non-AIDS human brains by immunohistochemical and Western blotting methods, and detected a 23 kDa protein which was immunoreactive with antibodies against HIVp17, a core protein of HIV with a molecular we...

journal_title：Neuroscience letters

authors： Kato T,Kurita K,Kawanami T,Sasaki H

更新日期：1994-11-07 00:00:00

abstract：:Neurotrophic factors maintain and modulate neuron function in adults. We tested the hypothesis that neurotrophic factors rapidly alter intracellular calcium concentrations, thereby affecting neuron excitability. The majority of rat nodose neurons express TrkA, TrkB and TrkC receptor after 1 day in culture. Addition of...

journal_title：Neuroscience letters

authors： Lamb K,Bielefeldt K

更新日期：2003-01-09 00:00:00

abstract：:A prevailing hypothesis is that neurogenesis is reduced in depression and that the common mechanism for antidepressant treatments is to increase it in adult hippocampus. Reduced neurogenesis has been shown in healthy rats exposed to stress, but it has not yet been demonstrated in depressed patients. Emerging studies n...

journal_title：Neuroscience letters

authors： Petersén A,Wörtwein G,Gruber SH,El-Khoury A,Mathé AA

更新日期：2009-02-20 00:00:00

abstract：:Previous tracer studies have revealed the sacculus to be connected to the vestibular and cochlear nuclei in the guinea pig. Due to its own innervation pattern, an anterior and posterior part of the sacculus can be distinguished. The present study investigated whether the two parts differ concerning their fiber contrib...

journal_title：Neuroscience letters

authors： Gstoettner W,Burian M,Zundritsch R,Mayr R

更新日期：1991-01-28 00:00:00

abstract：:To assess cortical activity during pain perception, regional cerebral blood flow (rCBF) studies were done in humans using single photon emission computed tomography (SPECT) with the radiotracer Tc99m-HMPAO and magnetic resonance imaging localization. Normalized SPECT data were analyzed by region of interest and change...

journal_title：Neuroscience letters

authors： Apkarian AV,Stea RA,Manglos SH,Szeverenyi NM,King RB,Thomas FD

更新日期：1992-06-22 00:00:00

abstract：:This study examined what changes occur in upper-limb bilateral coordination during clapping as the movement frequency requirements were increased to the maximum. Subjects were required to begin the clapping action at approximately 1Hz and gradually increase the movement speed until their maximal frequency was achieved...

journal_title：Neuroscience letters

authors： Morrison S,Hong SL,Newell KM

更新日期：2009-05-01 00:00:00

abstract：:Somatostatin (SRIF) release from fetal rat cortical cells was stimulated by exposure to 10(-5) M N-methyl-D-aspartate (NMDA) (250 +/- 20% of basal at 96 h). A similar but much less potent effect was seen with kainate (KA) but not with quisqualate (Q) which inhibited SRIF release (KA 150 +/- 13%, Q 65 +/- 18% of basal ...

journal_title：Neuroscience letters

authors： Ham J,Rickards C,Scanlon M

更新日期：1991-08-19 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that causes hypoperfusion of the neurosensory retina. We investigated immunohistochemically the expression of the receptors for ET-1, ET(A) and ET(B), in control and locally detached retinas of the pig. Immunoreactivity for ET(A) was expressed in the innermost retinal la...

journal_title：Neuroscience letters

authors： Iandiev I,Uhlmann S,Pietsch UC,Biedermann B,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2005-08-12 00:00:00

abstract：:Kynurenic acid (KYNA), a neuroactive metabolite of tryptophan that acts on different receptors (e.g. those of N-methyl-D-aspartate (NMDA) and presynaptic α7 nicotinic acetylcholine (nACh)), exerts fundamentally antiglutamatergic effects. In view of its antiglutamatergic properties, an elevation of the KYNA level withi...

journal_title：Neuroscience letters

authors： Demeter I,Nagy K,Farkas T,Kis Z,Kocsis K,Knapp L,Gellert L,Fülöp F,Vecsei L,Toldi J

更新日期：2013-10-11 00:00:00

abstract：:The left adrenal gland of the rat was perfused in vitro via the adrenal vein with Krebs-bicarbonate solution to study accumulation of exogenous catecholamines and secretion of endogenous norepinephrine and epinephrine by exposing the gland to various sympathomimetic agents. Perfusions with high concentrations of norep...

journal_title：Neuroscience letters

authors： Wakade AR,Wakade TD

更新日期：1984-09-07 00:00:00

abstract：:Unusual reactions to auditory stimuli are often observed in autism and may relate to ineffective inhibitory modulation of sensory input (sensory gating). A previous study of P50 sensory gating did not reveal abnormalities in high-functioning school age children [C. Kemner, B. Oranje, M.N. Verbaten, H. van Engeland, No...

journal_title：Neuroscience letters

authors： Orekhova EV,Stroganova TA,Prokofyev AO,Nygren G,Gillberg C,Elam M

更新日期：2008-03-28 00:00:00

abstract：:A restricted recovery of visual excitation occurs in the partially deafferented dorsal lateral geniculate nucleus (dLGN) of the cat after retinal lesions. In the absence of axonal growth an increase of retinogeniculate synapses at the peripheral dendrites of deafferented cells could be a possible underlying mechanism....

journal_title：Neuroscience letters

authors： Eysel UT,Neubacher U

更新日期：1984-08-24 00:00:00

abstract：:As the pre-dementia phase of Alzheimer disease, mild cognitive impairment (MCI) involves the onset and development of cognitive impairments. Opioid receptors play pivotal roles in the regulation of learning and cognition. Our study focused on the association of OPRK1 and OPRM1 methylation with MCI in Xinjiang Uygur an...

journal_title：Neuroscience letters

authors： Liu G,Ji H,Liu J,Xu C,Chang L,Cui W,Ye C,Hu H,Chen Y,Zhou X,Duan S,Wang Q

更新日期：2017-01-01 00:00:00

abstract：:We aimed to compare immunoreactivity patterns of four different anti-α-syn antibodies in surgical specimens of the gastrointestinal tract of Parkinson disease and control cases. Surgical specimens from stomach, small and large bowel of 6 PD cases and 12 controls were studied. Primary antibodies: anti-α-syn clone KM51,...

journal_title：Neuroscience letters

authors： Aldecoa I,Navarro-Otano J,Stefanova N,Sprenger FS,Seppi K,Poewe W,Cuatrecasas M,Valldeoriola F,Gelpi E,Tolosa E

更新日期：2015-08-18 00:00:00

abstract：:We have used Lucifer Yellow for histological tracing of displaced amacrine cells within the ganglion cell layer (GCL) during the embryonic development of the chicken retina. Incubating whole eyes in the dye leads to bright staining of all displaced amacrine cells, whereas ganglion cells and glial cells are not stained...

journal_title：Neuroscience letters

authors： Layer PG,Vollmer G

更新日期：1982-08-16 00:00:00

abstract：:We have investigated the presence of mutations in the parkin gene in patients with early-onset parkinsonism. Direct sequencing of the polymerase chain reaction (PCR) products showed a homozygous G deletion in the exon 7 (c.871delG) in one patient. This was a 38-year-old Moroccan woman with a history of parkinsonism of...

journal_title：Neuroscience letters

authors： Muñoz E,Pastor P,Martí MJ,Oliva R,Tolosa E

更新日期：2000-07-28 00:00:00

abstract：:Estrogen levels in rats are positively correlated with enhanced memory function and hippocampal dendritic spine density. There is much less work on the long-term effects of estradiol manipulation in preadolescent rats. The present work examined how injections of estradiol during postnatal days 19-22 (p19-22; preadoles...

journal_title：Neuroscience letters

authors： Wartman BC,Keeley RJ,Holahan MR

更新日期：2012-10-24 00:00:00

abstract：:IL-1beta is a proinflammatory cytokine that contributes to psychological stress responses and has been implicated in various psychiatric disorders most notably depression. Preclinical studies also demonstrate that IL-1beta modulates anxiety- and fear-related behaviors, although these findings are difficult to assess b...

journal_title：Neuroscience letters

authors： Koo JW,Duman RS

更新日期：2009-05-29 00:00:00

abstract：:To study the spatial frequency (SF) effects on cortical face processing, we recorded magnetoencephalographic responses in seven healthy subjects to upright and inverted human faces. Four face types were used, including original (broad-band SF, BSF), low SF (LSF, <5 cycles/face), middle SF (MSF, 5-15 cycles/face), and ...

journal_title：Neuroscience letters

authors： Hsiao FJ,Hsieh JC,Lin YY,Chang Y

更新日期：2005-05-20 00:00:00

abstract：:Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+...

journal_title：Neuroscience letters

authors： Ohnuma T,Shibata N,Matsubara Y,Sato S,Yamashina M,Arai H

更新日期：2003-05-29 00:00:00

abstract：:In rats, immunoreactivity was demonstrated in the brush border of the choroid plexus, in the wall of blood vessels in the brain, and in the brush border of the proximal tubules of the kidney, using the peroxidase-antiperoxidase technique (PAP) and an anti-pulmonary converting-enzyme antibody. These findings correlate ...

journal_title：Neuroscience letters

authors： Rix E,Ganten D,Schüll B,Unger T,Taugner R

更新日期：1981-03-10 00:00:00