Detection of a 23 kDa human brain protein that shares epitope(s) with the 17 kDa core protein of human immunodeficiency virus (HIV).

abstract：:Alpha-2 macroglobulin (A2M) is a serum pan-protease inhibitor that is related with the pathogenesis of Alzheimer's disease (AD) through its ability to mediate amyloid beta degradation. Recently, it has been reported that the I1000V polymorphism in A2M gene might increase the risk of AD. In the present study, we invest...

journal_title：Neuroscience letters

authors： Shibata N,Ohnuma T,Takahashi T,Ohtsuka E,Ueki A,Nagao M,Arai H

更新日期：2000-08-25 00:00:00

abstract：:The binding of the lectin soybean agglutinin (SBA) to the olfactory system of both the rat and mouse was investigated histochemically. SBA bound to fibers in the accessory olfactory nerve and to glomeruli in the accessory olfactory bulb. In addition, SBA binding sites were present in some, but not all, glomeruli in th...

journal_title：Neuroscience letters

authors： Key B,Giorgi PP

更新日期：1986-08-29 00:00:00

abstract：:Traumatic stress has been believed to result in a variety of unusual alterations of the integrity and the functionality in the hippocampus. In this study, we searched for genes responsive to traumatic stress in the mouse hippocampus to elucidate the underlying mechanisms. Adult male mice were subjected to water-immers...

journal_title：Neuroscience letters

authors： Tamaki K,Kamakura M,Nakamichi N,Taniura H,Yoneda Y

更新日期：2008-03-15 00:00:00

abstract：:Epigallocatechin gallate (EGCG) is a constituent of green tea, and increasing evidence suggests that EGCG has neuroprotective effects on oxidative stress-injured neuronal cells, especially motoneurons. Although the neuroprotective effects of EGCG have been demonstrated in Parkinson's and Alzheimer's diseases and ische...

journal_title：Neuroscience letters

authors： Koh SH,Lee SM,Kim HY,Lee KY,Lee YJ,Kim HT,Kim J,Kim MH,Hwang MS,Song C,Yang KW,Lee KW,Kim SH,Kim OH

更新日期：2006-03-06 00:00:00

abstract：:The adenosine triphosphate (ATP)-dependent sodium/potassium pump extrudes intracellular sodium in exchange for extracellular potassium. Low ATP causes pump dysfunction increasing both intracellular sodium and water thereby enhancing metabolite mobility. This should be detectable by proton magnetic resonance spectrosco...

journal_title：Neuroscience letters

authors： Cady EB,Lorek A,Penrice J,Wylezinska M,Cooper CE,Brown GC,Owen-Reece H,Kirkbride V,Wyatt JS,Osmund E

更新日期：1994-12-05 00:00:00

abstract：:Sciatic section in rats evokes chronic hyperalgesia, autotomy pain behavior, and hindpaw edema, a constellation resembling complex regional pain syndrome (CRPS) in man. Glucocorticoid treatment inhibits these sequelae of sciatic section and also blocks neurogenic extravasation. Small diameter afferent neurons release ...

journal_title：Neuroscience letters

authors： Kingery WS,Agashe GS,Guo TZ,Davies MF,Clark JD,Maze M

更新日期：2002-01-18 00:00:00

abstract：:6-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transporters, to inhibit mitochondrial respiration and to generate intracellular reactive oxygen species. In this study, we show that the anti-oxidants catalase, glutathione and N-acetyl-cysteine are able to reverse the toxic ...

journal_title：Neuroscience letters

authors： Blum D,Torch S,Nissou MF,Benabid AL,Verna JM

更新日期：2000-04-14 00:00:00

abstract：:This study evaluates the potential neuroprotective properties of amburoside A, a glucoside isolated from Amburana cearensis, on rat mesencephalic cell cultures exposure to the neurotoxin 6-hydroxydopamine (6-OHDA). The parameters determined were cell viability by the 3[4,5-dimethylthiazole-2-il]-2,5-diphenyltetrazoliu...

journal_title：Neuroscience letters

authors： Leal LK,Nobre Júnior HV,Cunha GM,Moraes MO,Pessoa C,Oliveira RA,Silveira ER,Canuto KM,Viana GS

更新日期：2005-11-11 00:00:00

abstract：:Olprinone, an inhibitor of cyclic nucleotide phosphodiesterase III, inhibited an increase in intracellular Ca(2+) concentrations for acutely dissociated rat hippocampal pyramidal neurons induced by extracellular high K(+) (35 mM) depolarization. Olprinone (100 microM) significantly reduced spontaneous glutamate releas...

journal_title：Neuroscience letters

authors： Fujikawa H,Kanno T,Nagata T,Nishizaki T

更新日期：2008-12-26 00:00:00

abstract：:Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...

journal_title：Neuroscience letters

authors： Rojas L,Zuazaga C

更新日期：1991-04-01 00:00:00

abstract：:We studied the effect of synthetic rat alpha-atrial natriuretic polypeptide (1-28) (ANF-(99-126)) and related atrial natriuretic polypeptides on the accumulation of cyclic GMP (cGMP) in isolated rat choroid plexus in vitro, the objective being to determine whether ANF-(99-126) binding sites are physiologically active ...

journal_title：Neuroscience letters

authors： Tsutsumi K,Niwa M,Kawano T,Ibaragi M,Ozaki M,Mori K

更新日期：1987-08-18 00:00:00

abstract：:In the real world, some of the auditory and visual information received by the human brain are temporally asynchronous. How is such information integrated in cognitive processing in the brain? In this paper, we aimed to study the semantic integration of differently asynchronous audio-visual information in cognitive pr...

journal_title：Neuroscience letters

authors： Liu B,Wu G,Wang Z,Ji X

更新日期：2011-07-01 00:00:00

abstract：:Periostin has dual roles as a multifunctional cytokine and an extracellular matrix protein that binds to several integrins on a variety of cells. This study evaluated whether the expression and cellular localization of periostin changes in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), a...

journal_title：Neuroscience letters

authors： Choi Y,Kim J,Ahn M,Shin T

更新日期：2020-01-10 00:00:00

abstract：:In vitro pituitary adenylate cyclase activating polypeptide (PACAP) induces the expression of brain-derived neurotrophic factor (BDNF) via its specific receptor PAC1. Since BDNF has been implicated in learning paradigms and mice lacking functional PAC1 have deficits in hippocampus-dependent associative learning, we in...

journal_title：Neuroscience letters

authors： Zink M,Otto C,Zörner B,Zacher C,Schütz G,Henn FA,Gass P

更新日期：2004-04-22 00:00:00

abstract：:Although minocycline has been generally thought to have neuroprotective properties, the neuroprotective role of minocycline has not been investigated in the animal model of epilepsy. In this study, we investigated whether minocycline is neuroprotective against kainic acid (KA)-induced cell death through the caspase-de...

journal_title：Neuroscience letters

authors： Heo K,Cho YJ,Cho KJ,Kim HW,Kim HJ,Shin HY,Lee BI,Kim GW

更新日期：2006-05-08 00:00:00

abstract：:Turnover rates, as estimated from the accumulation of the intermediates, 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in the ...

journal_title：Neuroscience letters

authors： Shum AY,Chen CS,Hsu SC,Chen CF

更新日期：1987-03-31 00:00:00

abstract：:Alzheimer' disease is a neurodegenerative disorder characterized by the misfolding and aggregation of amyloid β (Aβ). This process is influenced through supply of cholesterol via apolipoproteins to neurons. In the present study, we used the transgenic Caenorhabditis elegans strain CL2006, which expresses Aβ1-42 under ...

journal_title：Neuroscience letters

authors： Regitz C,Wenzel U

更新日期：2014-07-25 00:00:00

abstract：:This study examines the ultrastructural relationships established by the nigrostriatal dopaminergic and the corticostriatal afferent fibers with neuropeptide Y (NPY)-containing neurons in the rat striatum. By means of dual immunolabeling procedures using peroxidase conjugated F(ab) fragments and 125I-labeled protein A...

journal_title：Neuroscience letters

authors： Vuillet J,Kerkerian L,Kachidian P,Bosler O,Nieoullon A

更新日期：1989-05-22 00:00:00

abstract：:Several studies have shown that blockade of colony stimulating factor-1 (CSF-1) or its receptor (CSF-1R) inhibits disease progression in rodent models of rheumatoid arthritis (RA); however, the role of the CSF-1/CSF-1R pathway in RA-induced pain and functional deficits has not been studied. Thus, we examined the effec...

journal_title：Neuroscience letters

authors： Alvarado-Vazquez PA,Morado-Urbina CE,Castañeda-Corral G,Acosta-Gonzalez RI,Kitaura H,Kimura K,Takano-Yamamoto T,Jiménez-Andrade JM

更新日期：2015-01-01 00:00:00

abstract：:Following the iontophoretic deposition of Phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral medullary raphe, which included portions of the caudal nucleus raphe magnus, rostral nucleus raphe pallidus, rostral nucleus raphe obscurus and rostral nucleus reticularis paragigantocellularis, two-color immunoperoxi...

journal_title：Neuroscience letters

authors： Nicholas AP,Hancock MB

更新日期：1990-01-01 00:00:00

abstract：:[3H] Overflow evoked by 5 min supramaximal preganglionic stimulation at 1 pps has been studied in isolated guinea pig superior cervical ganglion preparations preincubated with [3H]choline. At 15 microM norepinephrine (NE) reduced both the [3H]choline overflow and endogenous acetylcholine release by 59.4 and 54.1% resp...

journal_title：Neuroscience letters

authors： Belluzzi O,Travagli RA,Bonifazzi C,Perri V

更新日期：1987-01-02 00:00:00

abstract：:Aβ-mediated oxidative stress damage is considered a direct cause of Alzheimer's disease (AD). Therefore, drugs that have been developed to block oxidative stress are considered effective for AD treatment. Isosilybin is a flavonoid compound extracted from Silybum marianum, and it has been confirmed to have many pharmac...

journal_title：Neuroscience letters

authors： Zhou J,Chao G,Li Y,Wu M,Zhong S,Feng Z

更新日期：2016-10-06 00:00:00

abstract：:The psychophysiological basis of problem size effect in the arithmetical processing of additions and subtractions was studied with event-related brain potentials (ERP). Subjects were presented sequences of seven numbers, and ERPs elicited to the sixth number were analyzed. Two variables were manipulated: operation typ...

journal_title：Neuroscience letters

authors： Núñez-Peña MI,Honrubia-Serrano ML,Escera C

更新日期：2005-01-03 00:00:00

abstract：:The conductance increase induced by bath application of GABA has been measured in voltage-clamped stretch-receptor neurones of crayfish. A rapid conductance increase was obtained only at GABA concentrations above 3.3 X 10(-4) M. The response to lower GABA concentrations (between 10(-4) and 10(-6) M) developed slowly o...

journal_title：Neuroscience letters

authors： Deisz RA,Dose M,Lux HD

更新日期：1984-06-29 00:00:00

abstract：:Somatosensory amplification refers to the tendency to experience benign and ambiguous somatic sensation as intense, noxious, and disturbing. The construct is helpful in assessing the perceptual style of a variety of somatizing conditions, but there is no human study clarifying the effects of neurological function on s...

journal_title：Neuroscience letters

authors： Nakao M,Barsky AJ,Nishikitani M,Yano E,Murata K

更新日期：2007-03-26 00:00:00

abstract：:We immunohistochemically investigated the degeneration processes of the nigro-striatal and nigro-amygdaloid pathways and the relationship between the loss of dopaminergic neurons and Lewy bodies (LB) formation in the substantia nigra using 15 autopsied cases of dementia with Lewy bodies (DLB). The number of tyrosine h...

journal_title：Neuroscience letters

authors： Iseki E,Marui W,Yamamoto R,Togo T,Katsuse O,Kato M,Iwatsubo T,Kosaka K,Arai H

更新日期：2005-05-20 00:00:00

abstract：:The DNA-damaging effect of the potent dopaminergic neurotoxin 'TaClo' (1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline) is reported. After irradiation (300 nm, 350 nm) of cell-free pBR322 DNA in the presence of TaClo, single-strand breaks were observed by gel electrophoresis. It seems likely that TaClo undergoes a...

journal_title：Neuroscience letters

authors： Bringmann G,Münchbach M,Feineis D,Faulhaber K,Ihmels H

更新日期：2001-05-18 00:00:00

abstract：:Stress increases associative learning and the density of dendritic spines in the hippocampus of male rats. In contrast, exposure to the same stressor impairs associative learning and reduces spine density in females. These effects in females are most evident when they are in the proestrus phase of the estrous cycle. A...

journal_title：Neuroscience letters

authors： Dalla C,Whetstone AS,Hodes GE,Shors TJ

更新日期：2009-01-02 00:00:00

abstract：:To understand the genetic origin of I2020T mutation in the kinase domain of leucine rich repeat kinase 2 (LRRK2), we investigated the original PARK8 Japanese family (Sagamihara family) and a German family (family 32), both of which were found to harbor I2020T as the causal mutation for autosomal dominant familial Park...

journal_title：Neuroscience letters

authors： Ohta E,Hasegawa K,Gasser T,Obata F

更新日期：2007-04-24 00:00:00

abstract：:Sapogenins from Anemarrhenae asphodeloides was reported to improve the learning and memory abilities. In this study, we investigated the effect of Timosaponin B-II(TB-II), a purified extract from A. asphodeloidesb on rat vascular dementia (VD) produced by transient (2h) middle cerebral artery occlusion. The learning a...

journal_title：Neuroscience letters

authors： Li TJ,Qiu Y,Yang PY,Rui YC,Chen WS

更新日期：2007-06-27 00:00:00