Spontaneous openings of large and small conductance acetylcholine receptor channels in Xenopus myocytes.

abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

journal_title：Neuroscience letters

authors： Bach SV,Tacon PR,Morgan JW,Hegde AN

更新日期：2015-03-30 00:00:00

abstract：:The aim of the present study was to examine the patterns of activation of the P600 waveform of the event-related potentials (ERP), applying principal component analysis (PCA) and repeated measures ANOVA, and whether these patterns are RF and gender dependent. The ERPs of thirty-nine healthy subjects (20 male and 19 fe...

journal_title：Neuroscience letters

authors： Maganioti AE,Hountala CD,Papageorgiou CC,Kyprianou MA,Rabavilas AD,Capsalis CN

更新日期：2010-06-30 00:00:00

abstract：:Autosomal-dominant familial amyotrophic lateral sclerosis (FALS) is associated with mutation in the gene that encodes Cu/Zn superoxide dismutase (SOD1). We identified a novel missense mutation of SOD-1 (Cys6Gly) in exon 1 in a Japanese woman and her family. The illness showed rapid progression similarly to the FALS wi...

journal_title：Neuroscience letters

authors： Kohno S,Takahashi Y,Miyajima H,Serizawa M,Mizoguchi K

更新日期：1999-12-03 00:00:00

abstract：:An investigation was made of the effect of presynaptic inhibition on paired-pulse facilitation (PPF) of group Ia afferent excitatory postsynaptic potentials (EPSPs). The main finding from this study was that PPF was enhanced during presynaptic inhibition of compound Ia EPSPs. This increase in PPF is identical to that ...

journal_title：Neuroscience letters

authors： Stuart GJ,Redman SJ

更新日期：1991-05-27 00:00:00

abstract：:Alzheimer's disease (AD) brains contain high levels of advanced glycation endproducts (AGEs). Double immunostaining using anti-AGE and anti-apolipoprotein E (apoE) antibodies demonstrated that AGEs co-localized to a very high degree with apoE. We examined the binding of apoE to in vitro-prepared AGE-bovine serum album...

journal_title：Neuroscience letters

authors： Li YM,Dickson DW

更新日期：1997-05-02 00:00:00

abstract：:Monosynaptic evoked responses were used to localize dorsal root ganglion (DRG) afferent terminals within organotypic fetal mouse spinal cord explants which had been chronically exposed to purified bovine gangliosides during early development. Ganglioside grown cultures showed a highly significant increase in dorsal co...

journal_title：Neuroscience letters

authors： Baker RE

更新日期：1983-10-31 00:00:00

abstract：:The psychostimulant amphetamine (AMPH) is known to act as an indirect dopamine agonist by promoting dopamine release. Here we demonstrate direct AMPH inhibition of field potentials and Na+ currents in rat nucleus accumbens (NAc) neurons. The experiments were done with field potential recordings from NAc slices and who...

journal_title：Neuroscience letters

authors： Huang RC,Lin JY

更新日期：1998-08-07 00:00:00

abstract：:The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas. ...

journal_title：Neuroscience letters

authors： Devor M

更新日期：1983-09-30 00:00:00

abstract：:We evaluated the neuroprotective effects of systemically administered magnesium against N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Postnatal day (PND) 7 rats received unilateral intrastriatal injections of 25 nmol NMDA followed 15 min later by single or multiple doses of magnesium intraperito...

journal_title：Neuroscience letters

authors： McDonald JW,Silverstein FS,Johnston MV

更新日期：1990-02-05 00:00:00

abstract：:Rats were injected (i.p.) once daily with either 1 mg/kg CGP 56999A, a gamma-aminobutyric acid(B) (GABA(B)) receptor antagonist, or an equivalent volume of saline beginning 7 days prior to, and continuing for 7 days following, a unilateral 6-hydroxydopamine lesion of the nigrostriatal dopamine (DA) pathway. At the end...

journal_title：Neuroscience letters

authors： Enna SJ,Reisman SA,Stanford JA

更新日期：2006-10-02 00:00:00

abstract：:Oral administration of naloxone (10 mg/kg) antagonized the slowing of the intestinal transit caused by oral morphine (1, 2.5 and 5 mg/kg) in rats. Oral administration of naloxone (10 mg/kg) did not prevent the antinociceptive effect of orally administered morphine (2.5 mg/kg) in the tail-flick test carried out on rats...

journal_title：Neuroscience letters

authors： Jurna I,Kaiser R,Kretz O,Baldauf J

更新日期：1992-08-03 00:00:00

abstract：:Vlgr1 (very large G-protein coupled receptor 1) knockout mice against hybrid backgrounds of the 129/Ola and C57BL/6 mouse strains show hearing deficit and high susceptibility to audiogenic seizures. The present study examined how hearing impairment and susceptibility to audiogenic seizures in Vlgr1-deficient mice chan...

journal_title：Neuroscience letters

authors： Yagi H,Noguchi Y,Kitamura K,Sato M

更新日期：2009-09-18 00:00:00

abstract：:The number of granule cell dendritic spines per micrometer of dendritic length in the dorsal and ventral leaves of the dentate gyrus was quantified using light microscopic-Golgi preparations of normal adult rats. Spines were counted in terms of 3 categories of spine form for the 3 afferent termination zones of the mol...

journal_title：Neuroscience letters

authors： Desmond NL,Levy WB

更新日期：1985-03-15 00:00:00

abstract：:Regular physical activity benefits brain health and function. Physical activity performed by young adults is declining. However, the influence of diminished physical activity on cognitive performance and motor preparation in young adults remains unclear. This study measured changes in behavior and brain activity durin...

journal_title：Neuroscience letters

authors： Cirillo J,Finch JB,Anson JG

更新日期：2017-01-18 00:00:00

abstract：:A method is developed for PCR assay of mRNA using 28S rRNA as internal standard and its applicability is reported for 4 types of mRNA. It consists of reverse transcription of total RNA using primers selective for 28S rRNA and the message of interest. Routinely the 28S reaction mix is diluted 20,000-fold and the diluti...

journal_title：Neuroscience letters

authors： Khan I,Tabb T,Garfield RE,Grover AK

更新日期：1992-11-23 00:00:00

abstract：:The cytokine interleukin-6 (IL-6) may be a contributing mediator of CNS injury in several neurological disorders. To investigate the role of IL-6 in memory-related disorders, we examined transgenic mice (GFAP-IL6) with cerebral overexpression of IL-6 using paired-pulse facilitation, paired-pulse inhibition, and long-t...

journal_title：Neuroscience letters

authors： Bellinger FP,Madamba SG,Campbell IL,Siggins GR

更新日期：1995-09-29 00:00:00

abstract：:Neuromelanin (NM)-containing dopaminergic neurons in the substantia nigra are selectively vulnerable in Parkinson's disease (PD), suggesting the involvement of NM in the pathogenesis. NM is composed of protein, lipid, trace metals and melanin component, a mixture of eumelanin produced from dopamine (DA)-quinone and ph...

journal_title：Neuroscience letters

authors： Naoi M,Yi H,Maruyama W,Inaba K,Shamoto-Nagai M,Akao Y,Gerlach M,Riederer P

更新日期：2009-11-13 00:00:00

abstract：:Tripeptidyl peptidase-I (TPP-I) is a lysosomal exopeptidase which removes tripeptides from the N-terminus of small proteins. Mutations in the TPP-I gene result in a lethal neurodegenerative disease, late infantile neuronal ceroid lipofuscinosis. The pathological consequences of loss of activity are only manifested in ...

journal_title：Neuroscience letters

authors： Warburton MJ,Bernardini F

更新日期：2002-10-11 00:00:00

abstract：:A marked depression of evoked CA1 potentials was observed with the nucleotide analogues a,b-methylene ADP (AOPCP) and adenylimido-diphosphate (AIP) and with 2'-adenosine monophosphate (2'-AMP). While the depression elicited by 5'-nucleotides was completely antagonized by the action of adenosine deaminase, AOPCP and 2'...

journal_title：Neuroscience letters

authors： Lee KS,Schubert P,Emmert H,Kreutzberg GW

更新日期：1981-05-29 00:00:00

abstract：:The regulation of blood glucose level in intracerebroventricular (i.c.v.) administration with opioid alone or opioid withdrawal model was studied in ICR mice. In the first group, we found that i.c.v. administered morphine or beta-endorphin alone causes an elevation of blood glucose level. Blood glucose level induced b...

journal_title：Neuroscience letters

authors： Park SH,Sim YB,Kang YJ,Kim SM,Lee JK,Jung JS,Suh HW

更新日期：2010-06-07 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects various cultured neurons against apoptotic stimuli. To investigate whether PEDF acts not only on neurons, but also glial cells, we analyzed the effects of recombinant human PEDF (rhPEDF) on cytokine mRNA levels, t...

journal_title：Neuroscience letters

authors： Sanagi T,Yabe T,Yamada H

更新日期：2005-05-20 00:00:00

abstract：:Neurons of the rat amygdaloid body were labeled with horseradish peroxidase following its injection into contralateral nuclei of the amygdala. The results strongly suggest that there is a contralateral amygdaloid projection from the basal (dorsal and ventral) nuclei of amygdala; it terminates in the medial, central an...

journal_title：Neuroscience letters

authors： Nitecka L,Amerski L,Narkiewicz O

更新日期：1981-10-01 00:00:00

abstract：:Anterograde labelling following focal injections of Phaseolus vulgaris leucoagglutinin was used to identify the threedimensional cortical distribution of thalamocortical (TC) fibers from the ventrolateral nucleus of the thalamus of the cat. The labelled TC fibers were distributed usually in layers I and III of the mot...

journal_title：Neuroscience letters

authors： Shinoda Y,Kakei S

更新日期：1989-01-16 00:00:00

abstract：:Ibotenic acid was injected into 3 parts of the lateral rat hippocampus. The animals were sacrificed 100 days after treatment, and studied immunohistochemically. The lesioned side of the hippocampus was highly atrophic with extensive neuronal loss and gliosis. Although silver staining revealed no particular structures ...

journal_title：Neuroscience letters

authors： Nakamura Y,Takeda M,Niigawa H,Hariguchi S,Nishimura T

更新日期：1992-02-17 00:00:00

abstract：:Gastrin-releasing peptide (GRP) was demonstrated by immunohistochemistry and high-performance liquid chromatography to be present in the great majority of neurons in the geniculate ganglion of rat and man. This was in contrast to findings in the sphenopalatine ganglion of rat, where only little GRP was found, and in t...

journal_title：Neuroscience letters

authors： Hardebo JE,Suzuki N,Ekman R

更新日期：1992-05-25 00:00:00

abstract：:The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. The tail-flick latency (TFL) was used as a behavioral index of nociceptive responsiveness. The result showed microinj...

journal_title：Neuroscience letters

authors： Yang Z,Zhang Y,Wu G

更新日期：2001-06-22 00:00:00

abstract：:Mental simulation of movements has been widely used to infer about representational aspects of action. On a daily basis, motor planning and execution depends crucially both upon vision and kinesthesia. What if the former is lost? In this study we investigate the physiological changes induced during a mental simulation...

journal_title：Neuroscience letters

authors： Imbiriba LA,Rodrigues EC,Magalhães J,Vargas CD

更新日期：2006-05-29 00:00:00

abstract：:Advanced glycation end products (AGEs) in the brain were immunohistochemically examined in Alzheimer's disease (AD) and aging using anti-AGE antibody recognizing mainly carboxymethyllysine. AGE positive staining diffusely located in the neuronal perikarya of hippocampus and parahippocampus in AD and aged brains withou...

journal_title：Neuroscience letters

authors： Takedo A,Yasuda T,Miyata T,Mizuno K,Li M,Yoneyama S,Horie K,Maeda K,Sobue G

更新日期：1996-12-27 00:00:00

abstract：:Following various types of wounds and subsequent denervation, the reinnervation of the rabbit corneal epithelium was found to occur in two distinct phases that overlapped in time. In the first phase large numbers of collateral sprouts originated from the unmyelinated plexus at various distances proximal to the site of...

journal_title：Neuroscience letters

authors： Beuerman RW,Rózsa AJ

更新日期：1984-01-27 00:00:00

abstract：:Studies in humans use blood lactate to determine the degree of the exercise intensity, suggesting that exercise with elevated blood lactate concentrations results in increased BDNF plasma concentrations. However, it is not clear if lactate per se or rather other mechanisms are responsible for changes in blood BDNF con...

journal_title：Neuroscience letters

authors： Schiffer T,Schulte S,Sperlich B,Achtzehn S,Fricke H,Strüder HK

更新日期：2011-01-25 00:00:00