Abstract：
:Oral administration of naloxone (10 mg/kg) antagonized the slowing of the intestinal transit caused by oral morphine (1, 2.5 and 5 mg/kg) in rats. Oral administration of naloxone (10 mg/kg) did not prevent the antinociceptive effect of orally administered morphine (2.5 mg/kg) in the tail-flick test carried out on rats. It is concluded that oral naloxone locally blocks the constipating effect of morphine, while it fails to reduce the central action of morphine due to extensive metabolization after oral administration.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Jurna I,Kaiser R,Kretz O,Baldauf Jdoi
10.1016/0304-3940(92)90620-mkeywords:
subject
Has Abstractpub_date
1992-08-03 00:00:00pages
62-4issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90620-Mjournal_volume
142pub_type
杂志文章abstract：:The cellular localization of Thy-1 in the chick retina was investigated by selectively destroying certain populations of neurons with toxins. In control retinae four weeks after intravitreal injection of vehicle, there was strong immunoreactivity for Thy-1 in the nerve fibre layer, ganglion cell layer and inner plexif...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90164-o
更新日期：1991-02-11 00:00:00
abstract：:The AMPA receptor subunit GluR2 is downregulated in neurons following a wide range of neurological insults. Here we report that suppression of GluR2 gene promoter activity is associated with kainate (KA)-induced downregulation of GluR2 subunit levels in primary cultured cortical neurons. RT-PCR and Northern blotting s...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.04.027
更新日期：2006-07-31 00:00:00
abstract：:In a light microscopic study the ferric ion-ferrocyanide staining of the squid giant axon was investigated. In other neurons this stain is known to indicate excitable membranes with high sodium channel density, such as the node of Ranvier or the initial segment. In the squid the stain reacted in small patches of the a...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90055-2
更新日期：1985-06-12 00:00:00
abstract：:The distribution of astrocytes has been studied in whole-mounted horse and monkey retinae by the immunocytochemical localization of glial fibrillary acidic protein (GFAP). In the horse, astrocytes were found to be restricted to a narrow zone close to the optic nerve head. This is also the only region of the horse reti...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90556-8
更新日期：1987-07-09 00:00:00
abstract：:To investigate diurnal variations in opiate receptor binding, the amount of specifically bound [3H]naloxone was measured at 4-h intervals across a 24-h period in the forebrains of rats that had been housed under a controlled light--dark cycle (lights on from 07.00 to 19.00 h) for 3 weeks. A significant rhythm with a p...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90055-0
更新日期：1981-01-01 00:00:00
abstract：:This study analysed the equilibrium strategies and EMG activity during postural equilibrium in four different unstable surfaces. Thirteen team sport males were tested on a FLAT surface and on three different wobble boards (JAKOBS(®) with easy multidirectional displacements, FREEMAN with strong multidirectional displac...
journal_title：Neuroscience letters
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neulet.2013.05.025
更新日期：2013-08-26 00:00:00
abstract：:A replication-defective adenoviral vector containing the E. coli lacZ gene was directly injected into the ischemic or reperfused cerebral cortex of rats. An administration of adenoviral vector showed a slight to moderate expression of the lacZ gene in the cerebral cortex of the middle cerebral artery (MCA) region unti...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00243-7
更新日期：1997-04-18 00:00:00
abstract：:Intracellular recordings were performed in a midpontine slice preparation of the rat brain containing the mesencephalic trigeminal nucleus (MTN). In spite of the previous demonstration of an adenosine deaminase-containing plexus terminating on this nucleus, adenosine, adenosine 5'-triphosphate (ATP), alpha,beta-methyl...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90615-5
更新日期：1988-10-17 00:00:00
abstract：:In the injured brain, astrocytes become activated and increase GFAP expression; a phenomenon termed as astrogliosis. Previously, we have reported that DJ-1, a Parkinson's disease gene, positively regulates astrogliosis in the injured brain. Moreover, STAT3 is known to play a key role in the regulation of astrogliosis....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.08.025
更新日期：2018-10-15 00:00:00
abstract：:The effect of the N-methyl-D-aspartate (NMDA) receptor antagonist, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), on the ethanol-evoked release of brain ascorbate (AA) was investigated in freely moving rats using an in vivo voltammetry technique. Ethanol (1.0 g/kg, intraperitoneal injection, i.p.) increase...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90655-5
更新日期：1993-07-09 00:00:00
abstract：:The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90661-1
更新日期：1988-12-19 00:00:00
abstract：:To study zinc (Zn) mobility in the rat olfactory tract, brain distribution of 65Zn after injection into the olfactory bulb or amygdaloid nuclei was analyzed by autoradiography. Twenty-four hours after 65Zn injection into the olfactory bulb, 65Zn was distributed in the ipsilateral piriform cortex, amygdaloid nuclei and...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00181-x
更新日期：1997-03-28 00:00:00
abstract：:We evaluated long-term dynorphin A-immunoreactivity in the rat area postrema (AP) after the administration of cisplatin. First, rats were given 1, 5 and 10mg/kg body weight cisplatin (i.p.) and their behavior was monitored for 72h. We observed a delayed increase in pica 24-72h after injection, compared to the 24h befo...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.07.044
更新日期：2007-09-07 00:00:00
abstract：:We analyzed the participation of N-methyl-d-aspartate (NMDA) receptors in the neuronal damage caused by adult-onset hypothyroidism. Wistar rats were randomly assigned into four groups. The euthyroid group received tap water. The hypothyroid group received methimazole (60 mg/kg) in their drinking water to induce hypoth...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.02.017
更新日期：2009-04-10 00:00:00
abstract：:We studied the topographical distribution of laser sensory thresholds on the human hairy skin, using a small laser beam for pinprick and a large beam for warmth sensations. The threshold for pinprick sensation correlated positively with the distance from the brain, suggesting that Adelta nociceptors, the fibers which ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01038-7
更新日期：2000-05-12 00:00:00
abstract：:The activation of immature rat S1 neocortex by electrical stimulation of peripheral nerves and of the thalamus is described. The existence of a surface-positive potential of intracortical origin at an early stage of development is confirmed. It is also shown that both the augmenting and the recruiting phenomena can be...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(75)90052-x
更新日期：1975-08-01 00:00:00
abstract：BACKGROUND:Genetic factors may play important roles in the pathogenesis of Parkinson's disease, and more than 40 loci involved in Parkinson's disease have been identified. Due to differing allele frequencies across origins, the associations of these loci and sporadic Parkinson's disease in the Eastern Chinese populatio...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.135261
更新日期：2020-09-14 00:00:00
abstract：:We investigated corticospinal excitability during positive (execution) and negative (suppression) imageries for the right and left upper and lower limbs. In the Positive Imagery tasks, sixteen subjects were instructed to repeatedly imagine rotation of the index finger of the right or left hand, or the ankle of the rig...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.02.036
更新日期：2018-04-13 00:00:00
abstract：:The regulation of blood glucose level in intracerebroventricular (i.c.v.) administration with opioid alone or opioid withdrawal model was studied in ICR mice. In the first group, we found that i.c.v. administered morphine or beta-endorphin alone causes an elevation of blood glucose level. Blood glucose level induced b...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.03.014
更新日期：2010-06-07 00:00:00
abstract：:A fundamental question in human sexuality regards the neural substrate underlying sexually-arousing representations. Lesion and neuroimaging studies suggest that dorsolateral pre-frontal cortex (DLPFC) plays an important role in regulating the processing of visual sexual stimulation. The aim of this Functional Near-In...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.01.058
更新日期：2007-04-06 00:00:00
abstract：:Attention deficit hyperactivity disorder (ADHD) is a developmental disorder characterized by inattentiveness, motor hyperactivity and impulsivity. According to neuroimaging data, the neural substrate underlying ADHD seems to involve fronto-striatal circuits and the cerebellum. However, there are important discrepancie...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.07.020
更新日期：2005-12-02 00:00:00
abstract：:The pattern of projection of the ventrobasal thalamic complex (VB) upon the neocortical barrel field of normal and reeler mutant mice was determined by orthograde degeneration experiments and by Timm's histochemical method. In both reeler and normal mice the thalamic terminals are concentrated at the midcortical zone ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(76)90091-4
更新日期：1976-09-01 00:00:00
abstract：:This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeO...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90425-3
更新日期：1987-05-19 00:00:00
abstract：:Polypeptides phosphorylated in vivo in Drosophila mutants defective in learning and memory, were characterized by polyacrylamide gel electrophoresis of subcellular fractions obtained by phase partitioning in Triton X-114 [3]. In the mutants turnip, dunce and Shaker, one or more bands at a molecular weight range of 50-...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90602-2
更新日期：1989-10-09 00:00:00
abstract：:Seizures are relatively common in the first weeks of life and can have lasting effects on brain development due to glutamate excitotoxicity. The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority of glutamate uptake in the brain and mice with this gene deleted die from seizures. Therefore, we ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.10.037
更新日期：2007-01-22 00:00:00
abstract：:To investigate the physiological significance of microglia-derived plasminogen (PGn) in the central nervous system, we determined the effects of rat PGn on the secretion of plasminogen activator inhibitor (PAI) in cultured rat astrocytes by reverse zymography and Western blotting. The cultured astrocytes normally prod...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)00860-0
更新日期：2000-03-24 00:00:00
abstract：:Intracellular recordings were used to study the contribution of nicotinic and P2X receptors to synaptic transmission to morphologically identified myenteric neurons of guinea-pig ileum. Hexamethonium (100 microM) abolished fast excitatory synaptic potentials (EPSPs) in all orally projecting neurons, but fast EPSPs in ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00275-x
更新日期：1999-05-14 00:00:00
abstract：:Neuropathic pain (NP) is highly disabling, responds poorly to pharmacological treatment, and represents a significant cause of decreased quality of life in patients suffering from spinal cord injury (SCI). In recent years, cell therapy with autologous mesenchymal stromal cells (MSCs) has been considered as a potential...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.01.035
更新日期：2018-03-23 00:00:00
abstract：:Hemispheric asymmetries in spatial processing are generally considered to be responsible for the shorter reaction time (RT) of the left hand classically observed for right-handers when pointing at targets. Surprisingly, despite the special role which the right cerebral hemisphere is known to play in visual attention, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02313-8
更新日期：2001-11-23 00:00:00
abstract：:Nitric oxide (NO) plays a role in the secondary damage after spinal cord (SC) injury. NO is produced by the activity of two classes of enzymes: calcium-dependent constitutive nitric oxide synthase (NOS) and calcium-independent inducible NOS. To determine the time course of both NOS activities after SC injury, 50 Wista...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02540-x
更新日期：2002-02-22 00:00:00
