Constitutive and inducible nitric oxide synthase activities after spinal cord contusion in rats.

Abstract:

:Nitric oxide (NO) plays a role in the secondary damage after spinal cord (SC) injury. NO is produced by the activity of two classes of enzymes: calcium-dependent constitutive nitric oxide synthase (NOS) and calcium-independent inducible NOS. To determine the time course of both NOS activities after SC injury, 50 Wistar rats were submitted to severe SC contusion. NOS activities were assayed at the site of SC injury at several times after lesion. Results showed a significant increase of 138 and 96% in the constitutive NOS activity at 4 and 8 h after the lesion, respectively, as compared to sham-operated rats. iNOS activity was increased 72 h after lesion by 103% (P<0.05). In conclusion, both isoforms of NOS increase their activity at different time periods after SC injury.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Díaz-Ruiz A,Ibarra A,Pérez-Severiano F,Guízar-Sahagún G,Grijalva I,Ríos C

doi

10.1016/s0304-3940(01)02540-x

keywords:

subject

Has Abstract

pub_date

2002-02-22 00:00:00

pages

129-32

issue

3

eissn

0304-3940

issn

1872-7972

pii

S030439400102540X

journal_volume

319

pub_type

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