Primary cold-sensitive neurons in acutely dissociated cells of rat hypothalamus.

Abstract:

:Local warming or cooling of the preoptic and anterior hypothalamus (PO/AH) areas evokes various thermoregulatory responses in mammals. We have hypothesized that warm- and cold-sensitive neurons recorded in the PO/AH are multiple thermostats that regulate the core temperature against heat and cold, respectively. However, since the proportion of cold-sensitive neurons is low, it is still controversial whether primary cold-sensitive neurons exist in the PO/AH. To answer this question, we investigated cold-sensitive neurons with Ca(2+) imaging in acutely dissociated PO/AH cells. Their threshold temperatures were 27.3+/-0.44 degrees C (mean+/-SEM, n=55). In extracellular recordings cooling evoked discharges in these cold-sensitive neurons. We conclude that primary cold-sensitive neurons with low threshold temperatures exist in PO/AH.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Abe J,Okazawa M,Adachi R,Matsumura K,Kobayashi S

doi

10.1016/s0304-3940(03)00239-8

keywords:

subject

Has Abstract

pub_date

2003-05-15 00:00:00

pages

29-32

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304394003002398

journal_volume

342

pub_type

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