Abstract:
:Smoking cessation strategies are of prime medical importance. Despite availability of various pharmacological agents in combating addiction to nicotine, more effective medications are needed. Based on recent findings, the glutamatergic system in the brain may provide novel targets. Here, we evaluated the effects of acute administration of sub-anesthetic doses of ketamine, an NMDA receptor antagonist, in both male and female Sprague-Dawley rats trained to self-administer nicotine. Animals were injected subcutaneously with 5, 7.5 and 10 mg/kg ketamine or saline and the effects on the number of intravenous nicotine infusions during a 45 min session was measured. Ketamine treatment significantly reduced nicotine self-administration in a dose-dependent manner. Moreover, a differential sensitivity between the sexes was observed as male rats responded to a lower dose of ketamine and with higher magnitude of effect than female rats. It is concluded that glutamatergic receptor manipulations may offer a novel and potentially sex-dependent intervention in nicotine addiction.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Rezvani AH,Tizabi Y,Slade S,Getachew B,Levin EDdoi
10.1016/j.neulet.2018.01.022subject
Has Abstractpub_date
2018-03-06 00:00:00pages
98-102eissn
0304-3940issn
1872-7972pii
S0304-3940(18)30022-3journal_volume
668pub_type
杂志文章abstract::To understand the genetic origin of I2020T mutation in the kinase domain of leucine rich repeat kinase 2 (LRRK2), we investigated the original PARK8 Japanese family (Sagamihara family) and a German family (family 32), both of which were found to harbor I2020T as the causal mutation for autosomal dominant familial Park...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.02.086
更新日期:2007-04-24 00:00:00
abstract::Neurotrophic factors may be used to improve the growth and repair of injured peripheral nerves. In this study we determined the effectiveness of recombinant human growth hormone on peripheral nerve injury in the Wistar rat. The ulnar nerve of the rat was sectioned and its proximal and distal ends were sutured to eithe...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.09.020
更新日期:2011-10-24 00:00:00
abstract::Gamma gamma (gamma gamma) enolase amount and enolase isozyme activities were measured in brain structures involved in stress response (hypothalamic paraventricular and supraoptic nuclei, locus coeruleus, hippocampus, A1 and A2 regions, hypophysis). Analyses were made in rats after immobilization or adrenalectomy, two ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(90)90764-z
更新日期:1990-10-30 00:00:00
abstract::Our previous studies showed that corticospinal excitability during imagery of squeezing a foam ball was enhanced by somatosensory input generated by passively holding the ball. In the present study, using the same experimental model, we investigated whether corticospinal excitability was influenced by holding the obje...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.02.073
更新日期:2012-04-11 00:00:00
abstract::Physical exercise is beneficial to functional recovery after stroke. But its underling mechanism is still unknown. It is reported that neural stem cells (NSCs) proliferation, migration and differentiation play an important role in recovery following stroke, furthermore, stromal cell derived factor-1α (SDF-1α) and its ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.06.059
更新日期:2014-08-22 00:00:00
abstract::The effect of different frequencies of music on brain function was investigated through measurement of blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that exposure to Mozart's music (K. 205) leads to increased calcium/calmodulin-dependent dopamine synthesis in the brain, and that t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.09.073
更新日期:2011-01-03 00:00:00
abstract::Ibotenate and trans-D,L-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) are rigid analogues of glutamate. Ibotenate has been shown to activate phosphoinositide hydrolysis in rat brain slices. We now report that trans-ACPD also stimulates phosphoinositide hydrolysis but with much higher potency and efficacy than...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(90)90555-n
更新日期:1990-02-05 00:00:00
abstract::A new dipole tracing method, based on a realistic head model, was used to determine dipole locations and vector moments of interictal convexity sharp waves recorded (with conventional EEG technique) from the right fronto-temporal region in a patient with partial complex seizures. When the dipole locations in the head ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(90)90300-x
更新日期:1990-05-31 00:00:00
abstract::We describe a new model of neurogenic pulmonary edema in spinal cord injured Wistar male rats. The pulmonary edema was elicited by an epidural thoracic balloon compression spinal cord lesion, performed under a low concentration of isoflurane (1.5 or 2%) in air. Anesthesia with 1.5% isoflurane promoted very severe inte...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.06.053
更新日期:2007-08-16 00:00:00
abstract::The effect of partial isomerization of dietary alpha-linolenic acid on the monoaminergic neurotransmitters in piglets was studied. After feeding the animals for 14 days with diets containing or not trans alpha-linolenic acid, neurotransmitters related to the monoaminergic function were quantified in the frontal cortex...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00879-0
更新日期:2002-10-18 00:00:00
abstract::The depression of the amplitude of extracellularly recorded monosynaptic excitatory field potentials in the lumbar spinal cord of pentobarbitone anaesthetised rats and cats by three thienyl derivatives of GABA: 4-amino-3-(2-thienyl)-butanoic acid; 4-amino-3-(2-thienyl-5-methyl)-butanoic acid and 4-amino-3-(2-thienyl-5...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90799-q
更新日期:1993-09-03 00:00:00
abstract::A method for the histochemical demonstration of cells with the capacity to synthesize the enzyme GABA-transaminase is described. Intraventricular injection of ethanolamine-O-sulfate irreversibly inhibits brain GABA-transaminase activity. Within 17 h after the injection sufficient new enzyme is synthesized to allow his...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90023-3
更新日期:1980-03-01 00:00:00
abstract::Removal of glutamate from the synaptic cleft by astroglial glutamine synthase (GS) is a crucial step in the regulation of glutamate turnover and metabolism, thus participating in endogenous neuroprotective processes occurring within brain tissues. Here we investigated on the effect of inflammatory cytokines on GS acti...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.09.079
更新日期:2005-01-20 00:00:00
abstract::Considering the multiplicity of symptoms associated with multiple sclerosis (MS), there is possibility that hypocretin system function might be involved in the pathogenesis of the disease. The current study aimed to investigate the hypocretin-1 levels in cerebrospinal fluid (CSF) of MS patients in relation to differen...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.02.062
更新日期:2010-04-19 00:00:00
abstract::Alpha-2 macroglobulin (A2M) is a component of Lewy bodies, a hallmark of Parkinson's disease (PD). In 159 PD patients and 190 normal controls, we studied two A2M polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism method: a five-nucleotide deletion at the 5' splice site of exon 18; ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00003-4
更新日期:2002-08-02 00:00:00
abstract::The prioritized processing of threat is suggested to be motivated by anxiety, regulated by the parasympatheticus, and biased to the right hemisphere. However, according to an anterior dimensional model of negative affect this is unlikely to be true when threat is of social origin. Social threat is communicated by the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02558-7
更新日期:2002-02-15 00:00:00
abstract::By means of extracellular recordings, we studied thalamic ventrobasal complex neurons of rats tested first awake, and then anesthetized with pentobarbital. In both conditions, we found two groups of units in both states. The first group, displaying a spontaneous bursting activity, was not obviously responding to perip...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11847-p
更新日期:1995-08-18 00:00:00
abstract::Epigallocatechin-3-gallate (EGCG) is a powerful antioxidant with suggested neuroprotective action. This study investigated the protective effects of EGCG against retinal ganglion cells (RGCs) degeneration in an animal model of glaucoma. C57BL/6J mice (n=54) were divided randomly into four groups: normal control group ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.06.002
更新日期:2015-07-23 00:00:00
abstract::The beta-carbolines, methyl-beta-carboline-3-carboxylate (beta-CCM) and 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) are known to have pharmacological properties opposite to those of agonistic benzodiazepines. Convulsions induced by these drugs lead to differential patterns, such as clonus, myoclonic or t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90060-7
更新日期:1991-11-25 00:00:00
abstract::The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed i...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.05.057
更新日期:2008-08-01 00:00:00
abstract::Studies involving receptor protection have been used to define the functional involvement of specific receptor subtypes in tissues expressing multiple receptor subtypes. Previous functional studies from our laboratory demonstrate the feasibility of this approach when applied to neuronal tissues expressing multiple nic...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.09.002
更新日期:2006-01-09 00:00:00
abstract::Calpain activity of nerve growth factor (NGF)-induced rat pheochromocytoma (PC12) cells shows a transient diminution in the early phase of differentiation. Calpain activity can be further decreased by a cell-permeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(94)90246-1
更新日期:1994-03-28 00:00:00
abstract::L1 is a highly conserved cell adhesion molecule with complete homology of the cytoplasmic domain between the known mammalian protein sequences. Since the cytoplasmic domains of other adhesion molecules have been shown to influence adhesion, we have investigated the effects of deletion of the cytoplasmic domain on the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)12100-i
更新日期:1995-11-24 00:00:00
abstract::In this study, the effects of morphine in drinking water on autotomy in male F344 rats having undergone brachial nerve sections were assessed during a 3-week period. Morphine was self-administered orally in tap water by the rats. Rats administered morphine just after the nerve section or 1 week after the nerve section...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90886-c
更新日期:1992-07-20 00:00:00
abstract::We recently showed that dopamine (DA) and serotonin (5-HT) exert anticonvulsant effects against limbic seizures in rats mediated by hippocampal D(2) and 5-HT(1A) receptor stimulation. For exogenously administered monoamines, anticonvulsant activity was only observed following 70--400% and 80--350% increases in baselin...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.07.049
更新日期:2005-12-16 00:00:00
abstract::An antiserum to choline acetyltransferase, partially purified from bovine brain (anti-ChAT 1), when incubated with synaptosomes prepared from rat cerebral cortex in the presence of complement caused release of 10% of lactate dehydrogenase and 27% of ChAT. Sodium-dependent uptake of choline was totally abolished. Simil...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90469-6
更新日期:1986-10-08 00:00:00
abstract::The nuclear factor kappa B inducing kinase gene (NIK) is located near the region of the haplotype associated with progressive supranuclear palsy (PSP) in chromosome 17q. We have analysed the coding region of the NIK gene in PSP patients through single strand conformation polymorphism and direct sequencing, in order to...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00105-8
更新日期:2003-04-10 00:00:00
abstract::Delta9-THC and synthetic cannabinoids produce memory impairment in humans as well as in laboratory animals. The high concentration of cannabinoid CB1 receptors and the presence of endocannabinoids in the hippocampus suggest that a cannabinoid neurochemical system may play a role in learning and memory processes. Thus,...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.01.049
更新日期:2005-06-03 00:00:00
abstract::Pitch and duration -- either as written symbols or in auditory form -- are the basic structural properties in tones that form a melodic sequence. From the cognitive perspective, it is still a matter of debate whether, and at which processing stage, these two factors are processed independently or interdependently. The...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.05.101
更新日期:2008-08-15 00:00:00
abstract::Cerebrospinal fluid (CSF) was obtained from donor rats either during the dark or during the light period of their diurnal cycle, and infused into the lateral ventricle of recipient rats. Infusing recipient rats during their dark period with CSF from light-exposed donors reduced the motor activity, whereas, conversely,...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(76)90028-8
更新日期:1976-04-01 00:00:00