Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons.

abstract：:Parkinson's disease (PD) is characterized by the selective loss of dopaminergic (DAergic) neurons in the substantia nigra and the subsequent depletion of dopamine (DA). This study assessed the protective effects of costunolide on DA-induced apoptosis in human DAergic SH-SY5Y cells, and its regulation of DA metabolism-...

journal_title：Neuroscience letters

authors： Ham A,Lee SJ,Shin J,Kim KH,Mar W

更新日期：2012-01-24 00:00:00

abstract：:The accumulation of choline acetyltransferase (CAT) proximal to and nerve growth factor (NGF) distal to the intraneural site of tetrodotoxin (TTX) or batrachotoxin (BTX) injection in vivo was used to monitor orthograde and retrograde axonal transport. Orthograde axonal transport was blocked by BTX for up to 7-10 days ...

journal_title：Neuroscience letters

authors： Boegman RJ,Riopelle RJ

更新日期：1980-06-01 00:00:00

abstract：:Recent evidence indicates that the N-methyl-D-aspartate (NMDA) receptor-channel complex contains a glycine subunit whose activation may be necessary for channel operation. It has been previously shown that stimulation of the NMDA receptor leads to an increase in intracellular ionic Ca2+ [( Ca2+]i); therefore, we exami...

journal_title：Neuroscience letters

authors： Oliver MW,Shacklock JA,Kessler M,Lynch G,Baimbridge KG

更新日期：1990-07-03 00:00:00

abstract：:We examined the suggestion that some of the processes subserving learning through action-observation and motor-execution are different because sensory motor reafference is not available while the limb is at rest in the former condition. We confirmed the action-observation and motor-execution groups learned equally the...

journal_title：Neuroscience letters

authors： Hayes SJ,Andrew M,Elliott D,Roberts JW,Bennett SJ

更新日期：2012-01-11 00:00:00

abstract：:This study investigated differences in the neural time-course of cognitive conflict and emotional conflict control, using event-related potentials (ERPs). Although imaging studies have provided some evidence that distinct, dissociable neural systems underlie emotional and nonemotional conflict resolution, no ERP study...

journal_title：Neuroscience letters

authors： Xue S,Li Y,Kong X,He Q,Liu J,Qiu J

更新日期：2016-04-21 00:00:00

abstract：:It is known that the number of newly generated neurons is increased in the young and adult rodent subventricular zone (SVZ) and dentate gyrus (DG) after transient brain ischemia. However, it remains unclear whether increase in neurogenesis in the adult DG induced by ischemic stroke is transient or sustained. We here r...

journal_title：Neuroscience letters

authors： Wang C,Zhang M,Sun C,Cai Y,You Y,Huang L,Liu F

更新日期：2011-01-13 00:00:00

abstract：:FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigat...

journal_title：Neuroscience letters

authors： Španiel F,Horáček J,Tintěra J,Ibrahim I,Novák T,Čermák J,Klírová M,Höschl C

更新日期：2011-04-15 00:00:00

abstract：:We investigated a possible involvement of the prion protein in ventilatory control in four groups of mice, those deficient for the prion protein (PrP(c)), those overexpressing the prion protein, and two groups of genetically and age-matched controls. Ventilatory patterns of unrestrained mice were measured in a whole-b...

journal_title：Neuroscience letters

authors： Boudinot E,Tremblay P,Champagnat J,Foutz AS

更新日期：2002-04-26 00:00:00

abstract：:Apoptotic cell death is associated with condensation and fragmentation of the nuclear chromatin into apoptotic bodies. Such nuclei occur frequently following cerebral hypoxia-ischemia in 1 week old rats but seem sparse in older animals. We investigated the age dependence by counting pyknotic or punctate chromatin cont...

journal_title：Neuroscience letters

authors： Sidhu RS,Tuor UI,Del Bigio MR

更新日期：1997-02-21 00:00:00

abstract：:The induction of heme oxygenase-1 (HO-1), the 32 kDa heat shock protein, was examined in the traumatized rat brain. At 24 h after either mild or severe brain injury or sham surgery, HO-1 was immunolocalized in fixed sections of brain. After mild brain injury, hemorrhage was apparent in the subarachnoid space, external...

journal_title：Neuroscience letters

authors： Fukuda K,Panter SS,Sharp FR,Noble LJ

更新日期：1995-10-20 00:00:00

abstract：:Mutations in presenilins are the major cause of early onset familial Alzheimer disease. It has recently been argued that clinical presenilin mutations work as loss-of-function but not toxic gain-of-function. To investigate whether presenilins are involved in the regulation of the distribution of neuronal membrane lipi...

journal_title：Neuroscience letters

authors： Oikawa N,Goto M,Ikeda K,Taguchi R,Yanagisawa K

更新日期：2012-09-06 00:00:00

abstract：:Ibotenate induced a concentration- and largely calcium-dependent release of endogenous glutamate from guinea pig cerebro-cortical synaptosomes. In the absence of Mg2+, the response to ibotenate was enhanced through a mechanism involving N-methyl-D-aspartate (NMDA) receptors; this component was sensitive to the NMDA an...

journal_title：Neuroscience letters

authors： Jones PG,Roberts PJ

更新日期：1990-03-26 00:00:00

abstract：:Several novel melatonin receptor agonists, in addition to various formulations of melatonin itself, are either available or in development for the treatment of insomnia. Melatonin is thought to exert its effects principally through two high affinity, G-protein coupled receptors, MT1 and MT2, though it is not known whi...

journal_title：Neuroscience letters

authors： Fisher SP,Sugden D

更新日期：2009-06-26 00:00:00

abstract：:Single unit recordings were performed in the nuclei raphe dorsalis (RD) and raphe magnus (RM) of semi-chronic prepared cats during spontaneous or cryogenically induced sleep. Of the RD neurons 75% showed a discharge pattern which decreased during slow wave sleep and paradoxical sleep (PS); such a decrease in spiking w...

journal_title：Neuroscience letters

authors： Cespuglio R,Faradji H,Gomez ME,Jouvet M

更新日期：1981-07-02 00:00:00

abstract：:Mutations in the glucocerebrosidase gene (GBA) have recently been associated with an increased risk of Parkinson disease (PD). GBA mutations have been observed to be particularly prevalent in the Ashkenazi Jewish population. Interestingly, this population also has a high incidence of the Lrrk2 p.G2019S mutation which ...

journal_title：Neuroscience letters

authors： Nishioka K,Vilariño-Güell C,Cobb SA,Kachergus JM,Ross OA,Wider C,Gibson RA,Hentati F,Farrer MJ

更新日期：2010-06-21 00:00:00

abstract：:The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit. The α7 nAChR is considered a promising drug target for treatment of cognitive dysfunction in schizophrenia and improves memory and executive functions in patients a...

journal_title：Neuroscience letters

authors： Dyrvig M,Mikkelsen JD,Lichota J

更新日期：2019-06-21 00:00:00

abstract：:Acetylcholinesterase (AChE) is an essential enzymatic component of the neuromuscular junction where it is responsible for terminating neurotransmission by the cholinergic motor neurons. The enzyme at the neuromuscular junction (NMJ) is contributed primarily by the skeletal muscle where it is produced at higher levels ...

journal_title：Neuroscience letters

authors： Rotundo RL

更新日期：2020-09-14 00:00:00

abstract：:Astrocytic glial cells from neonatal rat brains were grown in primary culture. Dipeptidyl peptidase II (DPP-II) enzyme activity was measured in cells disrupted by nonionic detergent. The rate of enzyme activity was measured in the presence of various ions, under isosmotic conditions adjusted using mannitol and NaCl. D...

journal_title：Neuroscience letters

authors： Stevens BR,Fernandez A,Sumners C,Hearing L

更新日期：1988-07-08 00:00:00

abstract：:This article has been withdrawn at the request of the Editor-in-Chief. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...

journal_title：Neuroscience letters

authors： Sun Y,Zhou M,Wang D,Chen F,Wang Q,Han X,Cheng W

更新日期：2020-06-24 00:00:00

abstract：:We studied anxiety-like behavior in the elevated plus-maze (EPM) tests in male Lewis rats on days 2 and 4 of adjuvant arthritis (AA). In plasma we analyzed C-reactive protein (CRP), albumin, ACTH, corticosterone, in the hippocampus the mRNA expression of interleukin-1β (IL-1β), interleukin-6 (IL-6), corticotrophin rel...

journal_title：Neuroscience letters

authors： Skurlova M,Stofkova A,Jurcovicova J

更新日期：2011-01-07 00:00:00

abstract：:The purpose of the present experiment was to investigate the effect of vision on postural control following a lower limbs muscular fatigue. Ten adult males were asked to maintain a single leg upright posture as immobile as possible in two conditions of no-fatigue and fatigue of the calf muscles. This muscles fatigue w...

journal_title：Neuroscience letters

authors： Vuillerme N,Nougier V,Prieur JM

更新日期：2001-08-03 00:00:00

abstract：:Muscarinic cholinoreceptors regulate the neurosecretion process in vertebrate neuromuscular junctions. The diversity of muscarinic effects on acetylcholine (ACh) secretion may be attributed to the different muscarinic subtypes involved in this process. In the present study, the location of five muscarinic receptor sub...

journal_title：Neuroscience letters

authors： Tsentsevitsky AN,Kovyazina IV,Nurullin LF,Nikolsky EE

更新日期：2017-05-10 00:00:00

abstract：:Research indicates that threat-induced changes in standing balance are associated with shifts in attention focus. This study investigated whether distracting attention modifies threat-induced changes in standing balance. Twenty-five healthy young adults stood without (No Threat) and with (Threat) the possibility of re...

journal_title：Neuroscience letters

authors： Johnson KJ,Watson AM,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2020-01-18 00:00:00

abstract：:Melatonin is a tryptophan metabolite synthesized by the pineal gland. Recent research showed that melatonin has a protective effect in Alzheimer's disease (AD). However, its exact mechanism is still unclear. This study was designed to investigate the effects of long-term oral melatonin on spatial learning and memory, ...

journal_title：Neuroscience letters

authors： Sun C,Qiu X,Wang Y,Liu J,Li Q,Jiang H,Li S,Song C

更新日期：2020-09-14 00:00:00

abstract：:Neural stem cell (NSC) transplantation has exhibited considerable therapeutic potential in spinal cord injury. However, most experiments in animals have been performed by injecting these cells directly into the injured spinal cord. A cardinal feature of NSCs is their exceptional migratory ability through the nervous s...

journal_title：Neuroscience letters

authors： Takeuchi H,Natsume A,Wakabayashi T,Aoshima C,Shimato S,Ito M,Ishii J,Maeda Y,Hara M,Kim SU,Yoshida J

更新日期：2007-10-16 00:00:00

abstract：:Repeated stress triggers a wide range of adaptive changes in the central nervous system including the elevation of serotonin (5-HT) metabolism and an increased susceptibility to affective disorders. To begin to examine whether these changes are mediated by alterations in gene expression for tryptophan hydroxylase (TPH...

journal_title：Neuroscience letters

authors： Chamas F,Serova L,Sabban EL

更新日期：1999-06-04 00:00:00

abstract：:To isolate the footedness contribution from the hemispheric visual asymmetry contribution to the upright postural control, seven right and six left-footed healthy women were asked to balance on each unipodal stance on an unstable platform for each visual hemispaces. We compared lateral deviations of the centre of pres...

journal_title：Neuroscience letters

authors： Golomer E,Mbongo F

更新日期：2004-09-02 00:00:00

abstract：:The factors determining the large variation seen in human corpus callosum (CC) morphology are as yet unknown. In this study heritability of CC size was assessed by comparing the concordance of CC midsagittal area in 14 monozygotic and 12 dizygotic twin pairs with a mean age of 27 years, using magnetic resonance imagin...

journal_title：Neuroscience letters

authors： Scamvougeras A,Kigar DL,Jones D,Weinberger DR,Witelson SF

更新日期：2003-02-27 00:00:00

abstract：:The distribution and cellular localisation of somatostatin receptor subtype 4 (SSTR4) was investigated in the adult rat brain using the technique of in situ hybridisation with subtype specific oligonucleotide probes. Somatostatin receptor subtype 4 was found mainly in the hippocampus CA1 > CA2 > CA3 pyramidal cells an...

journal_title：Neuroscience letters

authors： Harrington KA,Schindler M,Humphrey PP,Emson PC

更新日期：1995-03-16 00:00:00

abstract：:The photoactivable compound phenylazide interacts reversibly with the frog's olfactory epithelium when delivered as an olfactory stimulus. Its application together with UV irradiation resulted in a differential reduction of the responses (electro-olfactogram) to several odorants. It was found that this chemical modifi...

journal_title：Neuroscience letters

authors： Delaleu JC,Holley A

更新日期：1983-06-30 00:00:00