Abstract:
:FOXP2, the first gene known to be involved in the development of speech and language, can be considered to be, a priori, a candidate gene in schizophrenia, given the mounting evidence that the underlying core deficit in this disease could be a failure of structures relevant to normal language processing. To investigate the potential link between grey matter concentration (GMC) changes in patients with schizophrenia and the FOXP2 rs2396753 polymorphism previously reported to be associated with hallucinations in schizophrenia, we analysed high-resolution anatomical magnetic resonance images of 40 genotyped patients with schizophrenia and 36 healthy controls, using optimised voxel-based morphometry (VBM). Here we show that the common SNP rs2396753 (C>A) gene variant of the FOXP2 gene has significant effects on GMC in patients with schizophrenia, within regions of the brain known to be affected by this disease. Our data suggest that GMC reductions in schizophrenia may be driven by C allele carriers of the FOXP2 gene variant.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Španiel F,Horáček J,Tintěra J,Ibrahim I,Novák T,Čermák J,Klírová M,Höschl Cdoi
10.1016/j.neulet.2011.02.024subject
Has Abstractpub_date
2011-04-15 00:00:00pages
131-5issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(11)00181-9journal_volume
493pub_type
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