Abstract:
:Stimulation of murine primary microglia with Toll-like receptor (TLR) agonists enhances their ability to phagocytose and kill bacteria. Here we show that the viral TLR3 agonist poly(I:C) stimulates the release of cyto-/chemokines and nitric oxide by microglia. Poly(I:C) increases microglial phagocytosis and intracellular killing of Escherichia coli K1, a pathogenic encapsulated bacterial strain, after 30 and 90 min of co-incubation. Stimulation with a viral epitope may strengthen the resistance of the brain to bacterial infections in vivo. Our data encourage animal experiments with poly(I:C) derivatives to assess whether this approach can increase the resistance of the CNS against bacterial infections.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ribes S,Adam N,Ebert S,Regen T,Bunkowski S,Hanisch UK,Nau Rdoi
10.1016/j.neulet.2010.06.078subject
Has Abstractpub_date
2010-09-20 00:00:00pages
17-20issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(10)00852-9journal_volume
482pub_type
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