Naloxone-precipitated withdrawal enhances ERK phosphorylation in prefrontal association cortex and accumbens nucleus of morphine-dependent mice.

Abstract:

:Mitogen-activated protein kinases (MAPK) can be activated by opioids such as morphine via opioid receptor, and their activations have been observed in synaptic plasticity, learning, memory and addiction. Long-term exposure to morphine may induce physical dependence, manifested as somatic withdrawal symptoms such as diarrhea, body weight loss, jumping and headshaking, when drug is deprived. Though morphine dependence and withdrawal have been extensively studied, their molecular mechanisms have not been fully elucidated. In the present study, the physical dependence on morphine was developed in mice by an intermittent, escalating procedure of morphine injections, and was measured by the body weight loss and the behavioral signs (jumping and headshaking). We found that the mice with chronic morphine administration experienced dramatic body weight loss, compared with the saline-treated controls. Naloxone-precipitated withdrawal led to more body weight loss, compared with spontaneous withdrawal. Naloxone-precipitated withdrawal mice showed significantly aggravated morphine-withdrawal symptoms (including jumping and heading shaking), compared with spontaneous withdrawal mice. MAPK pathway activities in the frontal association cortex (FrA), accumbens nucleus (Acb) and caudate putamen (CPu) were examined to probe into molecular mechanism for morphine dependence and withdrawal. Compared with saline-treated mice, morphine-dependent mice and spontaneous withdrawal mice, naloxone-precipitated withdrawal mice showed a significantly increased ERK phosphorylation in FrA and Acb, but not in CPu. However, the activities of other protein kinases in the MAPK pathway, including p38 and JNK, showed no changes in FrA, Acb and CPu of the mice during the chronic morphine dependence and withdrawal phases. These results suggest that the ERK phosphorylation in FrA and Acb may be associated with naloxone-precipitated withdrawal syndrome.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Li T,Hou Y,Cao W,Yan CX,Chen T,Li SB

doi

10.1016/j.neulet.2009.11.030

subject

Has Abstract

pub_date

2010-01-14 00:00:00

pages

348-52

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(09)01496-7

journal_volume

468

pub_type

杂志文章
  • Investigations of the discriminative properties of the frog's olfactory mucosa using a photoactivable odorant.

    abstract::The photoactivable compound phenylazide interacts reversibly with the frog's olfactory epithelium when delivered as an olfactory stimulus. Its application together with UV irradiation resulted in a differential reduction of the responses (electro-olfactogram) to several odorants. It was found that this chemical modifi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90439-1

    authors: Delaleu JC,Holley A

    更新日期:1983-06-30 00:00:00

  • Human brain activation in response to olfactory stimulation by intravenous administration of odorants.

    abstract::To identify the BOLD effects related to olfaction in humans, we recorded functional magnetic resonance imaging (fMRI) scans in response intravenously instilled thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide monohydrochloride (TTFD). TPD and TTFD evoked a strong and weak odor sensation, respe...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.06.039

    authors: Miyanari A,Kaneoke Y,Noguchi Y,Honda M,Sadato N,Sagara Y,Kakigi R

    更新日期:2007-08-09 00:00:00

  • Effects of ascorbate in microdialysis perfusion medium on the extracellular basal concentration of glutamate in rat's striatum.

    abstract::There are many evidences suggest that ascorbate in the extracellular space can affect glutamate concentration in the rat's brain. In this report, we studied how ascorbate in microdialysis perfusion medium affected glutamate level at the striatum in freely-moving rats. Three perfusion mediums were used: 0, 250, and 400...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(99)00966-0

    authors: Lai YJ,Shen EY,Pan WH

    更新日期:2000-02-04 00:00:00

  • Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer's type.

    abstract::Serial sections of human brainstem were used to determine the total number of pigmented cells in locus coeruleus and, by immunohistochemical staining using an antiserum directed against human dopamine-beta-hydroxylase (DBH), the number of DBH-positive cells. In 12 brains from elderly control and dementia subjects ther...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90171-4

    authors: Iversen LL,Rossor MN,Reynolds GP,Hills R,Roth M,Mountjoy CQ,Foote SL,Morrison JH,Bloom FE

    更新日期:1983-08-19 00:00:00

  • NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3.

    abstract::NTAK (neural- and thymus-derived activator for ErbB kinases), also known as neuregulin-2 (NRG2), is a member of the epidermal growth factor (EGF) family, which binds directly to ErbB3 and ErbB4, and transactivates ErbB2. NTAK/NRG2 is structurally homologous to NRG1. The biological function of NTAK/NRG2 still remains u...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.04.050

    authors: Nakano N,Kanekiyo K,Nakagawa T,Asahi M,Ide C

    更新日期:2016-05-27 00:00:00

  • Changes in human diaphragmatic electromyogram with positive pressure breathing.

    abstract::An increase in diaphragmatic electromyogram (EMG) recorded via oesophageal electrodes during positive pressure breathing has been reported to indicate an increase in the neural outflow to the muscle. However, using similar techniques, the size of compound muscle action potentials produced by supramaximal phrenic nerve...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90442-8

    authors: McKenzie DK,Gandevia SC

    更新日期:1986-09-25 00:00:00

  • Effects of repeated dizocilpine treatment on glutamatergic activity in the prefrontal cortex in an animal model of schizophrenia: An in vivo proton magnetic resonance spectroscopy study at 9.4T.

    abstract::Repeated exposure to dizocilpine (MK-801) can be used as a model of schizophrenia that incorporates disease progression. Proton magnetic resonance spectroscopy (1H MRS) has been widely used to investigate schizophrenia-related alterations in glutamate (Glu). The purpose of this study was to investigate metabolic alter...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.11.053

    authors: Yoo CH,Song KH,Lim SI,Lee DW,Woo DC,Choe BY

    更新日期:2017-01-10 00:00:00

  • Re-innervation of rat molar tooth pulp following transection of the inferior alveolar nerve.

    abstract::The inferior alveolar nerves (IAN) of young male Wistar rats (b.wt. greater than or equal to 200 g) were transected unilaterally, slightly proximal to the mandibular foramen under anesthesia with chloral hydrate (0.4 g/kg, i.p.). After various postoperative periods of time, the animals received horseradish peroxidase ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90707-g

    authors: Takemura M,Sugimoto T,Wakisaka S,Akai M

    更新日期:1990-01-01 00:00:00

  • Dystrophin-like immunoreactivity in monkey and human brain areas involved in learning and motor functions.

    abstract::Two antidystrophin antibodies against different fragments of dystrophin were used to detect this polypeptide in monkey and human brains. Dystrophin was revealed by immunoperoxidase amplified with the biotin/avidin system and by immunoblotting. A dystrophin-like immunoreactivity was uniformly expressed in several brain...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90890-j

    authors: Huard J,Côté PY,Parent A,Bouchard JP,Tremblay JP

    更新日期:1992-07-20 00:00:00

  • Expression analysis of psychological stress-associated genes in peripheral blood leukocytes.

    abstract::In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2 h before and 2 or 24 h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compa...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.neulet.2005.01.081

    authors: Morita K,Saito T,Ohta M,Ohmori T,Kawai K,Teshima-Kondo S,Rokutan K

    更新日期:2005-06-10 00:00:00

  • Whole-cell recordings from sympathetic preganglionic neurons in rat spinal cord slices.

    abstract::Whole-cell patch-clamp recordings (WCR) were made from sympathetic preganglionic neurons (SPN) in neonate rat spinal cord slices. SPN were identified histologically by filling them with the fluorescent dye Lucifer Yellow contained within the patch pipette solution. Current clamp recordings were obtained from SPN with ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90405-i

    authors: Pickering AE,Spanswick D,Logan SD

    更新日期:1991-09-16 00:00:00

  • The 5-HT(4) receptor-induced depolarization in rat hippocampal neurons is mediated by cAMP but is independent of I(h).

    abstract::Intracellular recordings were used to examine the mechanisms underlying the 5-hydroxytryptamine (5-HT)4 receptor-mediated depolarization seen in CA1 region pyramidal cells in in vitro hippocampal brain slices. This depolarization was mimicked and occluded by administration of the membrane permeable cyclic adenosine mo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(02)00113-1

    authors: Chapin EM,Haj-Dahmane S,Torres G,Andrade R

    更新日期:2002-05-10 00:00:00

  • Cognitive alteration after carotid revascularization is correlated with cortical GABA(B)-ergic modulations.

    abstract::The present study evaluates the hypotheses that a GABAergic mechanism underlies neurobehavioral sequelae of carotid stenosis and that it can be reversed by carotid revascularization. We used the Rivermead Behavioural Memory Test (RBMT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.04.052

    authors: Murata K,Fujiki M,Ooba H,Kubo T,Morishige M,Abe T,Ishii K,Kobayashi H,Kiyosue H,Mori H

    更新日期:2011-08-18 00:00:00

  • Further observations on MxA-positive Lewy bodies in Parkinson's disease brain tissues.

    abstract::MxA protein, one of the GTPases, is induced in the cytoplasm by interferons and confers a high degree of resistance to some viruses. We recently reported that in cases of Parkinson's disease (PD), Lewy bodies (LBs) in the substantia nigra (SN) were positive for MxA. This study aimed to provide more detailed data on Mx...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11777-t

    authors: Yamada T

    更新日期:1995-07-28 00:00:00

  • Body response to binaural monopolar galvanic vestibular stimulation in humans.

    abstract::We investigated the possibility of obtaining an anteroposterior body response to galvanic vestibular stimulation (GVS) by applying an equivalent stimulus to both sides of the vestibular apparatus. An original 'double fronto-mastoidal' stimulation was used on eight subjects standing with their head facing forwards. Bot...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0304-3940(98)00161-x

    authors: Séverac Cauquil A,Gervet MF,Ouaknine M

    更新日期:1998-03-27 00:00:00

  • Upregulation of glutamatergic transmission in anterior cingulate cortex in the diabetic rats with neuropathic pain.

    abstract::Peripheral neuropathic pain is a common complication in the diabetic patients, and the underlying central mechanism remains unclear. Forebrain anterior cingulate cortex (ACC) is critically involved in the supraspinal perception of physical and affective components of noxious stimulus and pain modulation. Excitatory gl...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2014.03.038

    authors: Li W,Wang P,Li H

    更新日期:2014-05-07 00:00:00

  • Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat.

    abstract::Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment for patients with drug-resistant severe depressive disorders. However, the underlying biological m...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.03.069

    authors: Fryland T,Elfving B,Christensen JH,Mors O,Wegener G,Børglum AD

    更新日期:2012-05-10 00:00:00

  • Peroxisomal enzyme activities in brain and liver of pups of lactating mothers treated with ciprofibrate.

    abstract::Peroxisomal activities were examined in liver and brain of lactating neonatal rats of mothers maintained on ciprofibrate, a peroxisomal proliferator. The activities of DHAP-acyltransferase, alkyl-DHAP synthetase and the beta-oxidation of palmitic and lignoceric acids increased in brain by 3.9, 2.2, 4.3 and 3.2 fold an...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90934-y

    authors: Singh I,Lazo O

    更新日期:1992-04-27 00:00:00

  • Distribution of the pro-opiomelanocortin-immunoreactive axons in relation to the serotoninergic neurons in the dorsal raphe nucleus of the rat.

    abstract::The anatomical relationships between pro-opiomelanocortin-containing axons and serotonin neurons in the nucleus raphe dorsalis (NRD) of the rat were examined at the light microscope level with antibodies against CLIP (corticotropin-like intermediate lobe peptide), alpha-MSH (alpha-melanocyte-stimulating hormone) and s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90217-h

    authors: Zheng Z,Léger L,Cespuglio R,Jouvet M

    更新日期:1991-09-02 00:00:00

  • Analysis of PLA2G6 gene mutation in sporadic early-onset parkinsonism patients from Chinese population.

    abstract::Recent studies have shown that PLA2G6 is a causative gene for PARK14-linked autosomal recessive early-onset complicated dystonia-parkinsonism, early-onset parkinsonism with frontotemporal dementia and autosomal recessive early-onset Parkinsonism without added complicated clinical features. In order to investigate the ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.02.078

    authors: Tian JY,Tang BS,Shi CH,Lv ZY,Li K,Yu RL,Shen L,Yan XX,Guo JF

    更新日期:2012-04-18 00:00:00

  • Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.

    abstract::The N-methyl-D-aspartate (NMDA) receptor blocker 2-amino-5-phosphonovaleric acid [+/-)-2-APV) and kynurenic acid both suppressed spontaneous epileptiform burst discharges in the CA3 region of rat hippocampal slices. When the bursts were induced by perfusion with magnesium-free medium (+/-)-2-APV was the more potent in...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(88)90414-4

    authors: Stone TW

    更新日期:1988-01-22 00:00:00

  • Loss of otolith function with age is associated with increased postural sway measures.

    abstract::Loss of balance and increased fall risk is a common problem associated with aging. Changes in vestibular function occur with aging but the contribution of reduced vestibular otolith function to fall risk remains unknown. We examined a population of 151 healthy individuals (aged 21-93) for both balance (sway measures) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.08.057

    authors: Serrador JM,Lipsitz LA,Gopalakrishnan GS,Black FO,Wood SJ

    更新日期:2009-11-06 00:00:00

  • Spin labeling studies of membrane proteins in erythrocyte ghosts from patients with Huntington's disease.

    abstract::Previous electron spin resonance (ESR) studies employing a protein-specific spin label have suggested an alteration in membrane proteins in erythrocytes in Huntington's disease (HD). Recently, Beverstock and Pearson [4] have published the results of an ESR study not confirming our findings. In the present communicatio...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(83)90554-2

    authors: Butterfield DA,Markesbery WR

    更新日期:1983-02-21 00:00:00

  • Brain-wide map of projections from mice ventral subiculum.

    abstract::The hippocampal formation plays a critical role in episodic memory formation and spatial navigation. Within the hippocampus, the subiculum is considered to be a hub connecting the hippocampal formation to the remainder of the brain. There are functional differences between the dorsal and ventral part of subiculum, whi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.07.014

    authors: Tang H,Wu GS,Xie J,He X,Deng K,Wang H,Xu F,Luo HR

    更新日期:2016-08-26 00:00:00

  • Differential modulation of pressure pain threshold in response to transcutaneous spinal direct current stimulation with physical activity level.

    abstract::This study investigated the interaction between physical activity level and responses to transcutaneous spinal direct current stimulation (tsDCS) as reflected in changes in pressure pain threshold (PPT) in the lower extremity. Participants (n = 35, 15 males) consisted of physically active young adults. PPTs were deter...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2019.01.025

    authors: Gibson J,Tremblay F

    更新日期:2019-04-17 00:00:00

  • Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography.

    abstract::The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01752-3

    authors: Sörös P,Knecht S,Bantel C,Imai T,Wüsten R,Pantev C,Lütkenhöner B,Bürkle H,Henningsen H

    更新日期:2001-02-09 00:00:00

  • Effect of ketamine on amino acid-evoked release of acetylcholine from rat cerebral cortex in vitro.

    abstract::N-Methyl-D-aspartate (NMDA), quisqualate, kainate and potassium increased, in a dose-dependent manner, the efflux of radioactivity from rat cerebral cortex minislices preincubated with [3H]choline. Ketamine (1-5 microM) and magnesium (0.1-1 mM) reduced only the release evoked by NMDA. The non-parallel shift of the NMD...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(85)90271-x

    authors: Lodge D,Johnston GA

    更新日期:1985-05-23 00:00:00

  • Word-induced postural changes reflect a tight interaction between motor and lexico-semantic representations.

    abstract::A tight coupling between lexico-semantic access and motor control has been established on the basis of neuropsychological, neurophysiological, and behavioral evidence. For example, sensory and motor cortices have been shown to be active when subjects listen to words denoting bodily actions. Kinematic analyses of subje...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2013.09.021

    authors: Shiller DM,Bourguignon N,Frak V,Nazir T,Cadoret G,Robert M,Lemay M

    更新日期:2013-10-25 00:00:00

  • Vasoactive intestinal polypeptide facilitates muscarinic transmission in mammalian sympathetic ganglia.

    abstract::Vasoactive intestinal polypeptide (VIP) in the concentration of 1 microM or less markedly and selectively increased the amplitude and duration of the muscarinic slow excitatory postsynaptic potential (EPSP) without appreciably affecting the nicotinic fast EPSP or the non-cholinergic EPSP of guinea pig inferior mesente...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(84)90344-6

    authors: Mo N,Dun NJ

    更新日期:1984-11-23 00:00:00

  • Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells.

    abstract::The contribution of excitatory inputs to CA1 pyramidal cell death after ischemia was examined using rats with unilateral destruction of CA3 pyramidal cells. Intracerebroventricular injection of L-alpha-kainic acid (KA) was performed before the induction of transient forebrain ischemia. Five days after ischemic insult,...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90136-9

    authors: Onodera H,Sato G,Kogure K

    更新日期:1986-07-24 00:00:00