Ontogeny of cholecystokinin receptors in the human striatum.

Abstract:

:The distribution of cholecystokinin binding sites was studied by receptor autoradiography in the human striatum at midgestation, birth and adulthood. In the adult, cholecystokinin receptors are inhomogeneously distributed with patches of reduced labeling. In the caudate nucleus but not in the putamen these patches match the striosomal organization as revealed by acetylcholinesterase staining. At midgestation, patches of high density of cholecystokinin receptors are in register with the dopamine D1 receptor-enriched striosomes. At birth, this striosomal organization has already evolved into the adult pattern of higher matrix level in contrast to the striosomal pattern of acetylcholinesterase staining.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Schiffmann SN,Goldman S,Heyman P,De Vuyst M,De Roy G,Vanderhaeghen JJ

doi

10.1016/0304-3940(92)90329-6

keywords:

subject

Has Abstract

pub_date

1992-07-06 00:00:00

pages

39-42

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(92)90329-6

journal_volume

141

pub_type

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