PMA increases M3 muscarinic receptor levels and decreases retinal cells proliferation through a change in the levels of cell-cycle regulatory proteins.

abstract：:Cellular origins of methylarginines are not precisely known but the presence of free methyl and dimethylarginines in the brain were reported. We have investigated the circulating concentrations of asymmetrical dimethylarginine NG,NG-dimethylarginine (ADMA), NG,NG-dimethylarginine (SDMA), nitrate and nitrite levels in ...

journal_title：Neuroscience letters

authors： Das I,Khan NS,Puri BK,Hirsch SR

更新日期：1996-09-13 00:00:00

abstract：:Excessive activation of the N-methyl-D-aspartate (NMDA) receptor-channel complex has been implicated as one of the mechanisms by which ischemia-induced neuronal damage is mediated. Elevated glycine levels during ischemia may contribute to damage mediated by the NMDA receptor as glycine binding potentiates NMDA respons...

journal_title：Neuroscience letters

authors： Wood ER,Bussey TJ,Phillips AG

更新日期：1992-09-28 00:00:00

abstract：:The degree of contamination by blood in macroscopically clear cerebrospinal fluid (CSF) from the rat was assessed by the red blood cell count. Amino acid concentrations in the same samples were determined using high performance liquid chromatography. A significant positive correlation between the number of erythrocyte...

journal_title：Neuroscience letters

authors： Kornhuber ME,Kornhuber J,Kornhuber AW,Hartmann GM

更新日期：1986-08-29 00:00:00

abstract：:The strength of feedforward inhibition was assessed in the CA1 region of in vitro hippocampus of benzodiazepine tolerant rats 2 and 7 days after 1 week oral flurazepam (FZP) administration. Feedforward inhibition was activated with a Schaffer collateral stimulation just-subthreshold for a population spike followed at ...

journal_title：Neuroscience letters

authors： Zeng X,Xie XH,Tietz EI

更新日期：1994-05-23 00:00:00

abstract：:Nerve ligation injury in rats may represent a useful model of some clinical neuropathic pains. Activation of N-methyl-D-aspartate (NMDA) receptors may maintain central sensitivity and contribute to neuropathic pain. Here, nerve injury was produced by unilateral ligation of the L5 and L6 spinal roots of the sciatic ner...

journal_title：Neuroscience letters

authors： Ossipov MH,Lopez Y,Nichols ML,Bian D,Porreca F

更新日期：1995-10-20 00:00:00

abstract：:Glucose homeostasis was studied in the spontaneously hypertensive rat (SHR). The fasting plasma glucose levels were similar in the SHR and normotensive Wistar-Kyoto (WKY) rat (102.7+/-2.4 vs. 107.4+/-4.2 mg/dl, P > 0.01). One hour after glucose challenge, the plasma glucose level was slightly but insignificantly incre...

journal_title：Neuroscience letters

authors： Tong YC,Wang CJ,Cheng JT

更新日期：1997-09-19 00:00:00

abstract：:The presence of the neuron specific enolase (NSE) has been tested by sandwich enzyme immunoassay in cerebrospinal fluid (CSF) of rats after intrastriatal injection of various amounts of kainic acid (KA). Incremental release of NSE was observed in CSF for increasing concentrations of injected KA. Still, a significant d...

journal_title：Neuroscience letters

authors： Steinberg R,Scarna H,Pujol JF

更新日期：1984-03-23 00:00:00

abstract：:Present study was conducted to identify the efferents mediating the vasosensory reflexes evoked by intra-arterial (i.a.) injection of Mesobuthus tamulus (BT; 1mg/kg) venom in the distal segment of femoral artery. Blood pressure (BP), electrocardiogram (ECG) and respiratory movements were recorded for 60 min after the ...

journal_title：Neuroscience letters

authors： Singh SK,Deshpande SB

更新日期：2009-10-30 00:00:00

abstract：:In the present study, we tried to examine whether the 2-deoxy-D-[14C]glucose (2-DG) technique is useful to investigate the metabolic activity of fetal rat brain in the maternal uterus. The result shows that metabolic mapping of the fetal brain was clearly obtained by means of the 2-DG technique. ...

journal_title：Neuroscience letters

authors： Morimoto A,Imai-Matsumura K,Murakami N

更新日期：1990-03-26 00:00:00

abstract：:Selective loss of central dopaminergic neurons in vitro and in vivo can be initiated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) through its metabolite phenylpyridium ion (MPP+). Such MPTP-mediated cytotoxicity can be blocked by (-)-Deprenyl, a monoamine oxidase (MAO)-B inhibitor, but the exact mechanisms o...

journal_title：Neuroscience letters

authors： Le W,Jankovic J,Xie W,Kong R,Appel SH

更新日期：1997-03-21 00:00:00

abstract：:The spontaneous electrical activity of single neurons of the midbrain dorsal raphe nucleus in the rat was recorded in vitro in 400 mum thick slices. The majority of raphe neurons exhibited the slow and regular discharge pattern that characterizes the activity of raphe neurons when recorded in vivo. The viability of th...

journal_title：Neuroscience letters

authors： Mosko SS,Jacobs BL

更新日期：1976-06-01 00:00:00

abstract：:Gangliosides are sialic acid-containing sphingolipids that have promoting effects on the survival, growth, and functions of neurons in the central nervous system. Glial cells including astrocytes assist neurons with regard to their proliferation, maintenance, and function. In the present study, we found that astrocyte...

journal_title：Neuroscience letters

authors： Akasako Y,Nara K,Nagai Y,Hashimoto Y

更新日期：2011-01-20 00:00:00

abstract：:We report a sporadic case of tauopathy with unusual clinical and neuropathological features. The patient presented with progressive symmetric rigid-akinetic parkinsonism and dementia of the subcortical type. Magnetic resonance imaging of the brain revealed atrophy resembling multiple system atrophy. The level of cereb...

journal_title：Neuroscience letters

authors： Ohara S,Tsuyuzaki J,Oide T,Arai H,Higuchi S,Hasegawa M,Iwatsubo T

更新日期：2002-09-13 00:00:00

abstract：:The mammalian Period1 gene is rhythmically expressed and its proteins are found within the nucleus of the cells of the suprachiasmatic nuclei (SCN), the central circadian pacemaker in mammals; however, whether the target of the PER1 proteins is also the nucleus in the retinal peripheral clock cells is yet to be determ...

journal_title：Neuroscience letters

authors： García-Fernández JM,Alvarez-López C,Cernuda-Cernuda R

更新日期：2007-05-23 00:00:00

abstract：:Accumulating evidences have pointed out that neuroinflammation is involved in Parkinson's disease (PD) pathogenesis. Toll-like receptor 3 (TLR3), as a member of pattern-recognition receptors (PRRs), is known to play a pivotal role in inflammatory responses and immune responses. It was recently suggested that TLR3 was ...

journal_title：Neuroscience letters

authors： Wang J,Liu Y,Liu Y,Zhu K,Xie A

更新日期：2020-05-29 00:00:00

abstract：:The subventricular germinal zone (SVZ) retains an active population of stem cells and neural precursor cells throughout adulthood. EphrinB signaling mediates angiogenesis and vasculogenesis in the developing and adult brain. Recent studies indicate that molecules involved in angiogenesis often influence neurogenesis a...

journal_title：Neuroscience letters

authors： Katakowski M,Zhang Z,deCarvalho AC,Chopp M

更新日期：2005-09-16 00:00:00

abstract：:Neuropathic pain (NP) is highly disabling, responds poorly to pharmacological treatment, and represents a significant cause of decreased quality of life in patients suffering from spinal cord injury (SCI). In recent years, cell therapy with autologous mesenchymal stromal cells (MSCs) has been considered as a potential...

journal_title：Neuroscience letters

authors： Vaquero J,Zurita M,Rico MA,Aguayo C,Fernández C,Gutiérrez R,Rodríguez-Boto G,Saab A,Hassan R,Ortega C

更新日期：2018-03-23 00:00:00

abstract：:Event-related potentials were used to examine the role of grammatical gender in auditory sentence comprehension. Native Spanish speakers listened to sentence pairs in which a drawing depicting a noun was either congruent or incongruent with sentence meaning, and agreed or disagreed in gender with the immediately prece...

journal_title：Neuroscience letters

authors： Wicha NY,Bates EA,Moreno EM,Kutas M

更新日期：2003-08-07 00:00:00

abstract：OBJECTIVE:To investigate the protective effect of gliclazide and the role of dynamin-related protein l (Drp-1)-mediated oxidative stress and apoptosis in diabetic peripheral neuropathy (DPN). METHODS:Diabetic rats developed through intra-peritoneal injection of streptozotocin were randomly assigned to treatment group ...

journal_title：Neuroscience letters

authors： Wu YB,Shi LL,Wu YJ,Xu WH,Wang L,Ren MS

更新日期：2012-08-08 00:00:00

abstract：:Acetylcholine (Ach) has been considered a major neurotransmitter in the inner ear efferent nerve endings. A bioassay analysis has shown that the electrical stimulation of the crossed olivocochlear bundle increased the Ach-like activity in the perilymph. Applying in vivo microdialysis techniques and high-performance li...

journal_title：Neuroscience letters

authors： Hoya N,Ogawa K,Inoue Y,Takiguchi Y,Kanzaki J

更新日期：2001-10-05 00:00:00

abstract：:Vascular cognitive impairment (VCI) is the second most common cause of dementia after Alzheimer's disease, and the cognitive impairment is one of the common effects of VCI. Unfortunately, it lacks effective therapeutic treatments at present. In our previous study, environmental enrichment (EE), as an early interventio...

journal_title：Neuroscience letters

authors： Xu L,Qu C,Qu C,Shen J,Song H,Li Y,Li T,Zheng J,Zhang J

更新日期：2020-11-20 00:00:00

abstract：:Malnutrition affects a large number of children worldwide. Inadequate nutrition during pre- and postnatal period may alter brain development resulting in biochemical, physiological and anatomical changes which in turn could cause behavioral abnormalities. The impairment of the central nervous system following protein ...

journal_title：Neuroscience letters

authors： Bonatto F,Polydoro M,Andrades ME,Conte da Frota ML Jr,Dal-Pizzol F,Rotta LN,Souza DO,Perry ML,Fonseca Moreira JC

更新日期：2006-10-09 00:00:00

abstract：:It is well established that neurons in the dorsal medulla, including the area postrema and the medial nucleus tractus solitarius (mNTS), are involved in the central actions of circulating peptides such as angiotensin II (ANG II) and arginine vasopressin (AVP). This report describes a preparation that permits the ident...

journal_title：Neuroscience letters

authors： Hay M,Edwards GL,Lindsley K,Murphy S,Sharma RV,Bhalla RC,Johnson AK

更新日期：1993-03-19 00:00:00

abstract：:The present study is designed to screen the effect of syringin, an active principle purified from the rhizome and root parts of Eleutherococcus senticosus (Araliaceae), on the plasma glucose and investigate the possible mechanisms. Plasma glucose decreased in a dose-dependent manner 60 min after intravenous injection ...

journal_title：Neuroscience letters

authors： Liu KY,Wu YC,Liu IM,Yu WC,Cheng JT

更新日期：2008-03-28 00:00:00

abstract：:Nicotine is known to stimulate energy expenditure, although the precise mechanism is unclear. To clarify the involvement of corticotropin-releasing factor (CRF) in the mechanism by which nicotine increases energy expenditure, the effect of intraperitoneal injection of nicotine (0.1 or 0.5mg/kg) on the release of norad...

journal_title：Neuroscience letters

authors： Mano-Otagiri A,Iwasaki-Sekino A,Ohata H,Arai K,Shibasaki T

更新日期：2009-05-08 00:00:00

abstract：:DNA fragmentation and activation of caspase-1, implicating involvement of apoptosis, have been reported in the spinal cord of amyotrophic lateral sclerosis (ALS) patients and transgenic mouse models of ALS. Because BH3-only members of the Bcl-2 family have pro-apoptotic activity, we examined the expression of the BH3-...

journal_title：Neuroscience letters

authors： Shinoe T,Wanaka A,Nikaido T,Kanazawa K,Shimizu J,Imaizumi K,Kanazawa I

更新日期：2001-11-09 00:00:00

abstract：:The efficiency of antisense approaches to produce a selective regional inhibition of the expression of brain 5-HT1A receptors was tested in the rat. In vivo ICV injections of modified antisense oligodesoxynucleotides yielded at most an 18% specific decrease in 5-HT1A receptor expression in the hippocampus only, as mea...

journal_title：Neuroscience letters

authors： Sari Y,Sibella C,Vergé D,Hamon M,Miquel MC

更新日期：1999-01-15 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:The effects of free fatty acids (FFAs) on growth hormone releasing hormone (GHRH) secretion by fetal rat cortical and hypothalamic neurons in monolayer culture have been investigated. Treatment with caprylic or oleic acids for 90 min, induced a dose-dependent increase in GHRH secretion. The stimulatory effect of capry...

journal_title：Neuroscience letters

authors： Señaris RM,Lewis MD,Lago F,Dominguez F,Scanlon MF,Dieguez C

更新日期：1992-01-20 00:00:00

abstract：:The central projections of axotomized fibers were assessed to investigate how well these matched the modality of the reinnervated receptor. Our results using intrafiber injection of horseradish peroxidase (HRP) and cord dorsum potentials evoked by intracellular stimulation of single afferents indicate that regeneratin...

journal_title：Neuroscience letters

authors： Koerber HR,Seymour AW,Mendell LM

更新日期：1989-04-24 00:00:00