Abstract：
:Vascular cognitive impairment (VCI) is the second most common cause of dementia after Alzheimer's disease, and the cognitive impairment is one of the common effects of VCI. Unfortunately, it lacks effective therapeutic treatments at present. In our previous study, environmental enrichment (EE), as an early intervention for lifestyle modification, can ameliorate cognitive impairment by attenuating hippocampal blood-brain barrier (BBB) injury in chronic cerebral hypoperfusion (CCH) rats. However, the underlying mechanism remains unclear. Here, we found CCH rats in the standard environment (SE) developed cognitive impairment and BBB damage, which were significantly alleviated with the EE intervention. Meantime, EE improved the autophagy dysfunction caused by CCH in the hippocampus of rats, suggesting that the effect of EE on cognitive function and BBB may be related to the improvement of autophagy pathway.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Xu L,Qu C,Qu C,Shen J,Song H,Li Y,Li T,Zheng J,Zhang Jdoi
10.1016/j.neulet.2020.135437subject
Has Abstractpub_date
2020-11-20 00:00:00pages
135437eissn
0304-3940issn
1872-7972pii
S0304-3940(20)30707-2journal_volume
739pub_type
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