Abstract:
:Previous studies established that glutamate decarboxylase (GAD) is present in the brain of higher vertebrates in two forms composed of the homodimeric association of two subunits 59 and 63 kDa, respectively, that were found to be structurally related. We have performed quantitative comparative immunoblotting of whole brain and pituitary neurointermediate lobe (NIL) extracts. While GAD in the brain is present in cell bodies and nerve endings, it is known to be contained in the NIL exclusively in nerve endings that belong to a relatively long gamma-aminobutyric acid (GABA)ergic pathway of central origin. The relative immunolabelling ratio of the 59 kDa to the 63 kDa subunit was at least 10-fold higher in the NIL when compared to whole brain extracts. Accordingly we suggest that the GAD composed of the 59 kDa subunits, which appears to be greatly enriched in GABAergic nerve endings, might represent the form of GAD on which short term activity regulation is exerted in relation to neuronal activity. It might result from the post-translational processing of the GAD formed from the 63 kDa subunits during the axonal transport.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Henry S,Tappaz Mdoi
10.1016/0304-3940(91)90626-5subject
Has Abstractpub_date
1991-10-14 00:00:00pages
253-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(91)90626-5journal_volume
131pub_type
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