Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate.

abstract：:N-omega-[18F]fluoroethylketanserin ([18F]FEK), an 18F-labeled analogue of the serotonin S2 antagonist ketanserin, was evaluated for use with positron emission tomography (PET). PET imaging of a baboon brain following injection of [18F]FEK indicated that the fluorinated ligand rapidly localized in vivo within S2 recept...

journal_title：Neuroscience letters

authors： Moerlein SM,Perlmutter JS

更新日期：1991-02-11 00:00:00

abstract：:In order to clarify the mechanism of action of cerulenin analog, C75, known to suppress feeding behavior, food intake was measured in adult CD-1 male mice n=5 per group, treated i.p. with 10 and 20mg/kg of C75. Animals in both treatment groups had significantly lower 24h food consumption rate relative to the control g...

journal_title：Neuroscience letters

authors： Binienda ZK,Ross IA,Gough B,Riccio T,Kim CS,Ali SF

更新日期：2010-01-29 00:00:00

abstract：:The acute reactions of vasoactive intestinal polypeptide (VIP)-containing neurons in the myenteric plexus of the rat jejunum in response to circumferential clamping or transection/reanastomosis were evaluated in a detailed time course of up to ten days. Whereas in sham-operated controls VIP immunostaining was confined...

journal_title：Neuroscience letters

authors： Trudrung P,Waldner H,Sklarek J,Nitsch C

更新日期：1990-02-16 00:00:00

abstract：:The existence of a direct projection from retinal ganglion cells to vasoactive intestinal peptide (VIP)-like immunoreactive neuronal elements in the rat suprachiasmatic nucleus (SCN) was revealed by combining analysis of degenerating axons following enucleation and electron microscopic immunocytochemistry. Degeneratin...

journal_title：Neuroscience letters

authors： Ibata Y,Takahashi Y,Okamura H,Kawakami F,Terubayashi H,Kubo T,Yanaihara N

更新日期：1989-02-13 00:00:00

abstract：:The functional interaction in the spinal cord between substance P and excitatory amino acid agonists was investigated. Behavioural responses were scored in mice after intrathecal administration of excitatory amino acid agonists and substance P, given separately or in combination. A strong potentiation of the effect wa...

journal_title：Neuroscience letters

authors： Mjellem-Joly N,Lund A,Berge OG,Hole K

更新日期：1991-11-25 00:00:00

abstract：:Enteric glial cells are increasingly acknowledged as important partners of enteric neurons in the control of gastrointestinal function. They share morphological features and expression of antigenic markers with astrocytes of the central nervous system. Recently, aldehyde dehydrogenase 1 family member L1 (Aldh1L1) has ...

journal_title：Neuroscience letters

authors： Boesmans W,Rocha NP,Reis HJ,Holt M,Vanden Berghe P

更新日期：2014-04-30 00:00:00

abstract：:We evaluated effect of aging, gender and eye (sighting) dominance on relationship between visual evoked flow response (VEFR) and visual evoked potential (VEP), which refers to neurovascular coupling. The VEFR was defined as a percentage increase of the ratio of mean blood flow velocity in the contralateral (according ...

journal_title：Neuroscience letters

authors： Topcuoglu MA,Aydin H,Saka E

更新日期：2009-03-06 00:00:00

abstract：:Electrical high frequency deep brain stimulation (DBS) of the globus pallidus internus (GPi) or the subthalamic nucleus (STN) has dramatic beneficial motor effects in advanced Parkinson's disease (PD). However, the mechanisms underlying these clinical results remain unclear. It is proposed that the gamma-aminobutyric ...

journal_title：Neuroscience letters

authors： Li T,Qadri F,Moser A

更新日期：2004-11-23 00:00:00

abstract：:The mouse dopamine D4 receptor gene was isolated from a genomic DNA library by plaque hybridization. The D4 receptor gene encoded an open reading frame consisting of 387 amino acids, interrupted by three introns. Distribution of the D4 receptor mRNA in brain regions and peripheral tissues of mice was examined by rever...

journal_title：Neuroscience letters

authors： Suzuki T,Kobayashi K,Nagatsu T

更新日期：1995-10-13 00:00:00

abstract：:Immunochemical characterization of glutamic acid decarboxylase (GAD) from brain extracts of newborn and adult rats was investigated using a GAD antiserum that was previously raised against brain GAD from adult rats. According to the immunoprecipitation and saturation curves, no significant differences could be found a...

journal_title：Neuroscience letters

authors： Henry S,Tappaz M

更新日期：1989-05-22 00:00:00

abstract：:The effects of gonadal steroids on serotonin (5-HT) synthesis and metabolism in the early developing brain were investigated. Seven-day-old (7 days post-hatch) tilapia, Oreochromis mossambicus were continuously treated with 17beta-estradiol (E2), methyltestosterone (MT) and para-chlorophenylalanine (p-PCA) up to the a...

journal_title：Neuroscience letters

authors： Tsai CL,Wang LH

更新日期：1999-04-02 00:00:00

abstract：:Recently, we demonstrated that dimeric apocynin prevented loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic (tg) mouse (treated with 200mg/kg, three times per week) [B.P. Dranka et al., Neurosci. Lett. 549 (2013) 57-62]. Here we extend those studies by treating LRRK2(R1441G) mice wi...

journal_title：Neuroscience letters

authors： Dranka BP,Gifford A,McAllister D,Zielonka J,Joseph J,O'Hara CL,Stucky CL,Kanthasamy AG,Kalyanaraman B

更新日期：2014-11-07 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and blood vessel function. Recent evidence indicates that VEGF facilitates memory and learning through stimulating angiogenesis and neurogenesis in the rat hippocampal dendate gyrus. Abnormal regulation of VEGF expression has been reported ...

journal_title：Neuroscience letters

authors： Mateo I,Llorca J,Infante J,Rodríguez-Rodríguez E,Sánchez-Quintana C,Sánchez-Juan P,Berciano J,Combarros O

更新日期：2006-06-19 00:00:00

abstract：:This study examines the effect of acetylcholine (Ach) on parasympathetic vagal neurons in the dorsal motor nucleus of the vagus (DMNX). Patch-clamp techniques were utilized to examine voltage and ligand-gated currents in visualized DMNX neurons in an in vitro slice. Ach (100 microM) activated an inward current, -196.4...

journal_title：Neuroscience letters

authors： Neff RA,Hansen MK,Mendelowitz D

更新日期：1995-08-11 00:00:00

abstract：:Whole-cell patch-clamp recordings were made from kidney-related neurons in the intermediolateral cell column (IML) in horizontal slices of thoracolumbar spinal cord from adult rats. Kidney-related neurons were identified in vitro subsequent to inoculation of the kidney with a fluorescent, retrograde, transynaptic pseu...

journal_title：Neuroscience letters

authors： Derbenev AV,Duale H,Rabchevsky AG,Smith BN

更新日期：2010-05-03 00:00:00

abstract：:In a random number generation (RNG) task subjects are instructed to generate the numbers 1-10 in a random fashion. RNG performance is assumed to involve executive functions, as it requires controlled response generation and suppression of habitual responses. To investigate cerebral structures involved in RNG associate...

journal_title：Neuroscience letters

authors： Daniels C,Witt K,Wolff S,Jansen O,Deuschl G

更新日期：2003-07-10 00:00:00

abstract：:The aim of this study was to investigate trigeminal nerve involvement in patients with peripheral facial palsy. In total, 25 patients with facial nerve palsy and 19 controls were tested by electrophysiological methods regarding their facial and trigeminal nerve functions within 1 month after disease onset. The presenc...

journal_title：Neuroscience letters

authors： Uluduz D,Kiziltan ME,Akalin MA

更新日期：2010-07-26 00:00:00

abstract：:Early craniectomy has shown to reduce infarction size in experimental large MCA infarction probably due to improved leptomeningeal perfusion. Based on the hypothesis that craniectomy may also be beneficial in smaller MCA infarction we evaluated the effects of craniectomy on infarction size in small thromboembolic cere...

journal_title：Neuroscience letters

authors： Engelhorn T,Heiland S,Schabitz WR,Schwab S,Busch E,Forsting M,Doerfler A

更新日期：2004-11-11 00:00:00

abstract：:Near-infrared spectroscopy (NIRS) is a non-invasive optical technique which has been successfully used to register substantial cerebral ischemia. There are indications that NIRS is sensible enough to detect also small metabolic changes during the performance of cognitive tasks. In the present study, two-channel NIRS o...

journal_title：Neuroscience letters

authors： Fallgatter AJ,Strik WK

更新日期：1997-02-21 00:00:00

abstract：:Using a new polyclonal antibody against prostacyclin (PGI2)-synthase this enzyme was shown to be present in neuronal cells of bovine, rat and human brain, most abundantly in Purkinje cells of the cerebellum and cortical neurons, but not in glial cells. Western blots confirmed the specificity of the antibody and applie...

journal_title：Neuroscience letters

authors： Mehl M,Bidmon HJ,Hilbig H,Zilles K,Dringen R,Ullrich V

更新日期：1999-08-27 00:00:00

abstract：:Approximately 30% of all epilepsy cases are acquired. At present there is no effective strategy to stop epilepsy development after the precipitating insult. Recent data from experimental models pointed to the mTOR pathway, which can be potently inhibited by rapamycin. However, data on the antiepileptic and antiepilept...

journal_title：Neuroscience letters

authors： Sliwa A,Plucinska G,Bednarczyk J,Lukasiuk K

更新日期：2012-02-16 00:00:00

abstract：:Intracellular recordings were made from primary sensory hair cells located on the dorsal side of the anterior crista segment of the squid statocyst. These hair cells were electrophysiologically identified by the occurrence of an antidromic action potential after electrical stimulation of the crista nerve. Two types of...

journal_title：Neuroscience letters

authors： Chrachri A,Williamson R

更新日期：1993-10-29 00:00:00

abstract：:The role of the lateral hypothalamus (LHT) in the regulation of feeding behavior has long been established. The major contribution of LHT glucose-sensitive neurons, activated by low glucose concentration, is well accepted. Two peptidergic neuron populations, whose perikarya are exclusively located within this area, ha...

journal_title：Neuroscience letters

authors： Bahjaoui-Bouhaddi M,Fellmann D,Bugnon C

更新日期：1994-02-28 00:00:00

abstract：:Galanin- and bethanechol-activated whole cell currents were studied in dissociated mudpuppy parasympathetic neurons kept in 12.5 mM KCl. The bethanechol-induced current was reduced when generated during a galanin-induced current. The galanin and bethanechol currents reversed at -45 mV and exhibited inward rectificatio...

journal_title：Neuroscience letters

authors： Parsons RL,Merriam LA

更新日期：1992-06-08 00:00:00

abstract：:An intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1), that is located at a well established Alzheimer's disease (AD) locus on chromosome 9q22, was recently associated with increased risk for late-onset AD. We analyzed this polymorphism in two independent AD samples consisting of pa...

journal_title：Neuroscience letters

authors： Brouwers N,Sleegers K,Engelborghs S,Bogaerts V,van Duijn CM,De Deyn PP,Van Broeckhoven C,Dermaut B

更新日期：2006-01-09 00:00:00

abstract：:Changes in adenosine 3',5'-cyclic monophosphate (cAMP) concentration were measured in cortical synaptosomes. Preincubation with adenosine deaminase reduced cAMP concentration by 45%. Oxotremorine, clonidine, gamma-aminobutyric acid (GABA) and baclofen produced no change in basal concentration. 2-Chloroadenosine and no...

journal_title：Neuroscience letters

authors： Fillenz M,Bloomfield MR

更新日期：1986-02-28 00:00:00

abstract：:Acetate is the primary product of ethanol catabolism and can accumulate in the blood at concentrations of up to 2 mM following ethanol consumption. It has been suggested that some of the pharmacological actions of ethanol are mediated via acetate, which can lead indirectly to the release of endogenous adenosine. In th...

journal_title：Neuroscience letters

authors： Brundege JM,Dunwiddie TV

更新日期：1995-02-17 00:00:00

abstract：:The sensorimotor synapse of Aplysia exhibits long-term facilitation (LTF) and long-term depression (LTD) elicited by the neuromodulator serotonin (5-HT) and the peptide Phe-Met-Arg-Phe-NH(2), respectively. 5-HT-induced LTF engages extracellular-regulated kinase (Erk) and CREB1, whereas FMRFa-induced LTD engages p38 MA...

journal_title：Neuroscience letters

authors： Fioravante D,Smolen PD,Byrne JH

更新日期：2006-04-03 00:00:00

abstract：:Dendritic branching of neurons may be quantitatively studied using applications of graph theory. Dendritic ramifications may be considered as 'forests' of planted, stemmed, binary 'trees' with simple mathematical properties. Two fundamental numbers, that of dendritic tips and that of dendritic stems, usually suffice t...

journal_title：Neuroscience letters

authors： Percheron G

更新日期：1979-10-01 00:00:00

abstract：:Following sciatic nerve injury sympathetic invasion and basket formation is seen in dorsal root ganglia. We examined whether this phenomenon occurs in trigeminal ganglion (TG) following axotomy (IOAx) or chronic constriction injury to the infraorbital nerve (IOCCI). The IOCCI rats developed hyperresponsiveness to pinp...

journal_title：Neuroscience letters

authors： Benoliel R,Eliav E,Tal M

更新日期：2001-01-19 00:00:00