Genomic structure and tissue distribution of the mouse dopamine D4 receptor.


:The mouse dopamine D4 receptor gene was isolated from a genomic DNA library by plaque hybridization. The D4 receptor gene encoded an open reading frame consisting of 387 amino acids, interrupted by three introns. Distribution of the D4 receptor mRNA in brain regions and peripheral tissues of mice was examined by reverse transcription-polymerase chain reaction (RT-PCR). There was a remarkable expression of the receptor mRNA in various brain regions, showing the highest expression level in the cerebellum. Also, in the peripheral tissues a high level expression of the D4 mRNA was detected in the eye, adrenal gland and testes. We observed several differences in tissue distribution of the D4 mRNA in mice from that reported in other mammalian species.


Neurosci Lett


Neuroscience letters


Suzuki T,Kobayashi K,Nagatsu T




Has Abstract


1995-10-13 00:00:00














  • Cocaethylene synthesis in Drosophila.

    abstract::Cocaethylene is an active cocaine metabolite that targets mammalian neural reward pathways and thus contributes to the reinforcing and addictive properties of ethanol and cocaine. Using gas chromatography-mass spectrometry, we find that fruit flies (Drosophila melanogaster) possess a cellular mechanism through which c...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Torres G,Horowitz JM

    更新日期:1999-03-26 00:00:00

  • 4-aminopyridine activates a cholinergic chloride conductance in isolated Helix neurons.

    abstract::Isolated Helix neurons were internally perfused under voltage-clamp, with drugs applied by the 'concentration clamp' which allowed an extremely rapid switching of the external solution. 4-Aminopyridine (4-AP) at more than 3 X 10(-4) M induced a chloride current (ICl) which could be blocked by D-tubocurarine. Acetylcho...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ikemoto Y,Akaike N,Ono K

    更新日期:1987-04-23 00:00:00

  • Fos induction in brainstem neurons by intravenous hypertonic saline in the conscious rat.

    abstract::Experiments were done in conscious rats to investigate the effect of intravenous infusion of hypertonic saline on the induction of the protein Fos, in brainstem neurons. Neurons containing Fos-like immunoreactivity were observed in the caudal nucleus of the solitary tract (NTS), the caudal and rostral ventrolateral me...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Hochstenbach SL,Solano-Flores LP,Ciriello J

    更新日期:1993-08-20 00:00:00

  • Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells.

    abstract::Recent studies have shown that the inhibition of histone deacetylases (HDACs) induces the differentiation of diverse cancer and stem cells, which suggests HDAC inhibitors may be good candidates for the induction of stem cell differentiation. In this study, we investigated the effects of a HDAC inhibitor, valproic acid...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Jeong SG,Ohn T,Kim SH,Cho GW

    更新日期:2013-10-25 00:00:00

  • The action of the A1 noradrenergic region on the activity of subfornical organ neurons in the rat.

    abstract::Electrical stimulation of the A1 noradrenergic region of the ventrolateral medulla produced synatic excitation (n = 19, 9%), inhibition (n = 5, 2%) or no effect (n = 184, 89%) in the activity of a total of 208 neurons in the subfornical organ (SFO) in male rats under urethane anesthesia. Almost all (n = 18) of the exc...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Tanaka J,Mashiko N,Kawakami A,Hatakenaka S,Fujisawa S,Nomura M

    更新日期:2002-10-25 00:00:00

  • Differential effects of butyrate and dibutyryl cAMP on mRNA levels of muscarinic acetylcholine receptor subtypes expressed in neurohybrid cell lines.

    abstract::NCB-20 cells expressed m1- and m4-muscarinic acetylcholine receptor (mAChR) mRNAs, while NG108-15 cells expressed only m4-mAChR mRNA. Butyrate induced a time-dependent increase in the level of m1-mAChR mRNA with no change in the m4-mAChR mRNA level in NCB-20 cells. Similarly, butyrate did not affect the m4-mAChR mRNA ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Fukamauchi F,Mataga N,Wang YJ,Chuang DM

    更新日期:1996-07-05 00:00:00

  • 5'-Aza-dC sensitizes paraquat toxic effects on PC12 cell.

    abstract::Parkinson's disease (PD) is one of the common neurodegenerative diseases that result in the progressive damage of dopaminergic neurons. Environmental exposure, including paraquat, is considered risky for PD. Epigenetics refer to the study of heritable changes in gene expression that occur without a change in DNA seque...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kong M,Ba M,Liang H,Ma L,Yu Q,Yu T,Wang Y

    更新日期:2012-08-22 00:00:00

  • An extract of the marine alga Alaria esculenta modulates α-synuclein folding and amyloid formation.

    abstract::The conversion of α-synuclein from its natively unfolded and α-helical tetrameric forms to an amyloid conformation is central to the emergence of Parkinson's disease. Therefore, prevention of this conversion may offer an effective way of avoiding the onset of this disease or delaying its progress. At different concent...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Giffin JC,Richards RC,Craft C,Jahan N,Leggiadro C,Chopin T,Szemerda M,MacKinnon SL,Ewart KV

    更新日期:2017-03-22 00:00:00

  • Selective regulation of dendritic MAP2 mRNA levels in hippocampal granule cells by nitric oxide.

    abstract::Application of NMDA, or agents releasing nitric oxide (NO), onto the dendrites of hippocampal granule cells increased the levels of the mRNA encoding MAP2, a cytoskeletal component induced during periods of neurite outgrowth. Furthermore, local increases in the hybridisation signal in the molecular layer, representing...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Johnston HM,Morris BJ

    更新日期:1994-08-15 00:00:00

  • Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population.

    abstract::A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cyt...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Rosenmann H,Meiner Z,Dresner-Pollak R,Kahana E,Aladjem Z,Grenader T,Wertman E,Abramsky O

    更新日期:2004-06-10 00:00:00

  • Neural correlates of delayed episodic memory in patients with mild cognitive impairment--a FDG PET study.

    abstract::Mild cognitive impairment (MCI) is characterized by cognitive deficits which do not yet reach the threshold of dementia but represent a putative preclinical state of Alzheimer's disease (AD). Little is known about the neural correlates of delayed episodic memory which is among the earliest signs of cognitive decline i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Schönknecht OD,Hunt A,Toro P,Henze M,Haberkorn U,Schröder J

    更新日期:2009-12-25 00:00:00

  • Robust localization and lateralization of human language function: an optimized clinical functional magnetic resonance imaging protocol.

    abstract::An optimized clinical functional magnetic resonance imaging (fMRI) protocol with a total scanning time of 8 min is presented that localizes Broca's and Wernicke's areas robustly and determines hemispheric dominance. Language function was visualized using two different sentence generation (SG) and word generation (WG) ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Stippich C,Mohammed J,Kress B,Hähnel S,Günther J,Konrad F,Sartor K

    更新日期:2003-07-31 00:00:00

  • Involvement of the human dorsal premotor cortex in unimanual motor control: an interference approach using transcranial magnetic stimulation.

    abstract::Unilateral movements are enabled through a distributed network of motor cortical areas but the relative contribution from the parts of this network is largely unknown. Failure of this network potentially results in mirror activation of the primary motor cortex (M1) ipsilateral to the intended movement. Here we tested ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Cincotta M,Borgheresi A,Balestrieri F,Giovannelli F,Rossi S,Ragazzoni A,Zaccara G,Ziemann U

    更新日期:2004-09-02 00:00:00

  • Neuroprotective effects of Buyang Huanwu Decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats.

    abstract::Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, has been developed as a drug to be used for treatment of stroke for hundreds of years. However, the underlying mechanisms remain unknown. In the present study, the effects of BYHWD on delayed neuronal death of hippocampus after transient forebrain ischem...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Li XM,Bai XC,Qin LN,Huang H,Xiao ZJ,Gao TM

    更新日期:2003-07-31 00:00:00

  • Co-release of acetylcholine, glutamate and taurine from synaptosomes of Torpedo electric organ.

    abstract::The amino acid content of Torpedo synaptosomes was investigated. It was found that glutamate and taurine were particularly enriched, their concentration exceeding that of acetylcholine by 50-60%. Other amino acids such as alanine, gamma-aminobutyric acid (GABA), glycine, leucine and phenylalanine were also present, bu...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Vyas S,Bradford HF

    更新日期:1987-11-10 00:00:00

  • Producing the vowel/a/ prior to speaking inhibits stuttering in adults in the English language.

    abstract::This study investigated the effects of producing and listening to the vowel /a/ on the frequency of overt stuttering moments in eight people who stuttered. Stuttering frequency counts were made for the speech produced in the control condition, and after each of these four experimental conditions: (a) producing a vowel...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Dayalu VN,Saltuklaroglu T,Kalinowski J,Stuart A,Rastatter MP

    更新日期:2001-06-22 00:00:00

  • A study of GABAergic system in Scrapie-infected hamsters after striatal microinoculation of the agent.

    abstract::Experimental Scrapie in hamster is a simple, reproducible model of prion diseases that occur in humans and animals. Stereotaxic microinoculation (0.5 microliter) of the agent (263 K) into a specific cerebral structure (striatum) in hamster, previously developed in our group, gives the opportunity to further investigat...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Grégoire N,Lebrun F,Fahn L,Salamon G,Nicoli J

    更新日期:1993-12-12 00:00:00

  • Comparison of cytokine expression profile during Wallerian degeneration of myelinated and unmyelinated peripheral axons.

    abstract::Changes in cytokine and chemokine expression during Wallerian degeneration have been studied using nerve transection models, which result in denervation of both myelinating and non-myelinating Schwann cells. Cytokine and chemokine response of non-myelinating Remak Schwann cells to loss of their axons is unknown. In th...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Cheepudomwit T,Güzelsu E,Zhou C,Griffin JW,Höke A

    更新日期:2008-01-17 00:00:00

  • Gene-environment interactions between methylenetetrahydrofolate reductase (MTHFR) 677C>T and metabolic syndrome for the prevalence of ischemic stroke in Koreans.

    abstract::Although metabolic syndrome (MS) is recognized as a risk factor for ischemic stroke, little is known about genetic variants that confer susceptibility to ischemic stroke among individuals with or without MS. This study was completed to investigate whether the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorp...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kim OJ,Hong SH,Jeon YJ,Oh SH,Kim HS,Park YS,Kim EJ,Kim NK

    更新日期:2013-01-15 00:00:00

  • Expression of intrinsic bursting properties in neurons of maturing sensorimotor cortex.

    abstract::Intrinsically bursting (IB) neurons, responding with a burst of action potentials to just threshold intracellular depolarizing current pulses, are encountered in layer V of mature rodent sensorimotor cortex. We report the results of intracellular recordings performed on neocortical slices obtained from immature rats b...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Franceschetti S,Buzio S,Sancini G,Panzica F,Avanzini G

    更新日期:1993-11-12 00:00:00

  • Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid.

    abstract::Many biochemically diverse proteins can give rise to amyloid fibrils; however, they are all accompanied by P component and glucosaminoglycans. With antibodies specific to apolipoprotein E (apo E) we used immunohistochemical techniques to test for the presence of this protein in both cerebral and systemic amyloid. We f...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Wisniewski T,Frangione B

    更新日期:1992-02-03 00:00:00

  • Increased cortical nuclear factor-kappa B (NF-kappa B) DNA binding activity after traumatic brain injury in rats.

    abstract::Nuclear factor-kappa B (NF-kappa B) DNA binding factor is an inducible transcription factor that responds to various cellular signals. Levels of cortical NF-kappa B DNA binding activity were measured in a controlled lateral cortical impact model of traumatic brain injury (TBI) in rats. Using electrophoretic mobility s...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yang K,Mu XS,Hayes RL

    更新日期:1995-09-08 00:00:00

  • Stress and corticosterone enhance cognitive recovery from hippocampal stroke in rats.

    abstract::When locally infused, the potent vasoconstrictor, endothelin-1 (ET-1) produces partial ischemic damage in many regions of the brain, including the hippocampus. The hippocampus is known for a high density of glucocorticoid receptors and for the potent actions of stress and corticosterone to modulate function. The curre...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Faraji J,Lehmann H,Metz GA,Sutherland RJ

    更新日期:2009-10-25 00:00:00

  • Neuronal overexpression of cyclooxygenase-2 does not alter the neuroinflammatory response during brain innate immune activation.

    abstract::Neuroinflammation is a critical component in the progression of several neurological and neurodegenerative diseases and cyclooxygenases (COX)-1 and -2 are key regulators of innate immune responses. We recently demonstrated that COX-1 deletion attenuates, whereas COX-2 deletion enhances, the neuroinflammatory response,...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Aid S,Parikh N,Palumbo S,Bosetti F

    更新日期:2010-07-12 00:00:00

  • Effect of transposition on contractile and histochemical properties of muscle.

    abstract::In 16 rats, the extensor digitorum longus (EDL) - a fast muscle - was grafted, complete with its innervation, into the bed of the (removed) soleus - a slow muscle. Following the transposition, performed on one side only, EDL recovered and showed the contraction time of the contralateral EDL that served as control. How...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Gutmann E

    更新日期:1976-07-01 00:00:00

  • Thyrotropin-releasing hormone enhances event-related brain potentials and growth hormone release in man.

    abstract::Changes in contingent negative variation (CNV), a brain-evoked potential related in arousal, as well as in serum triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), prolactin (PRL), cortisol and growth hormone (GH) levels were recorded in 12 male volunteers receiving either thyrotropin-releasing ...

    journal_title:Neuroscience letters

    pub_type: 临床试验,杂志文章


    authors: Strollo F,Amabile G,Fattapposta F,Strollo G,More M,Riondino G

    更新日期:1988-11-11 00:00:00

  • Cognitive reappraisal of facial expressions: electrophysiological evidence of social anxiety.

    abstract::The present study investigates the effect of cognitive reappraisal on emotion regulation in socially anxious individuals. Twenty-eight female subjects were divided into high-socially anxious (HSA) and low-socially anxious (LSA) groups. All subjects viewed threatening faces under cognitive reappraisal and passive viewi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yuan L,Zhou R,Hu S

    更新日期:2014-08-08 00:00:00

  • Ganglioside GQ1b improves spatial learning and memory of rats as measured by the Y-maze and the Morris water maze tests.

    abstract::Gangliosides are major components of cell membranes and are particularly enriched in the mammalian brain where they represent the major lipid constituents of the neuronal cell surface. In the central nervous system, gangliosides have a close connection to many neurophysiological functions related to neurogenesis, prol...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Jung WR,Kim HG,Kim KL

    更新日期:2008-07-11 00:00:00

  • Caffeine-induced epileptic discharges in CA3 neurons of hippocampal slices of the guinea pig.

    abstract::In order to analyze the elementary mechanisms underlying caffeine-induced epileptiform discharges, hippocampal slices of guinea pigs were exposed to this drug. When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared. They were accompanied ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Moraidis I,Bingmann D,Lehmenkühler A,Speckmann EJ

    更新日期:1991-08-05 00:00:00

  • Effects of human, rat and porcine galanins on cardiac vagal action and blood pressure in the anaesthetised cat.

    abstract::Galanin (GAL) is distributed in sympathetic nerves in the cat, and exogenous GAL inhibits cardiac vagal action and lowers blood pressure in this species. This study on anaesthetised cats compares the effects on cardiac vagal action and blood pressure of human, rat and porcine GAL. Human GAL has only recently been sequ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ulman LG,Evans HF,Iismaa TP,Potter EK,McCloskey DI,Shine J

    更新日期:1992-02-17 00:00:00