Genomic structure and tissue distribution of the mouse dopamine D4 receptor.


:The mouse dopamine D4 receptor gene was isolated from a genomic DNA library by plaque hybridization. The D4 receptor gene encoded an open reading frame consisting of 387 amino acids, interrupted by three introns. Distribution of the D4 receptor mRNA in brain regions and peripheral tissues of mice was examined by reverse transcription-polymerase chain reaction (RT-PCR). There was a remarkable expression of the receptor mRNA in various brain regions, showing the highest expression level in the cerebellum. Also, in the peripheral tissues a high level expression of the D4 mRNA was detected in the eye, adrenal gland and testes. We observed several differences in tissue distribution of the D4 mRNA in mice from that reported in other mammalian species.


Neurosci Lett


Neuroscience letters


Suzuki T,Kobayashi K,Nagatsu T




Has Abstract


1995-10-13 00:00:00














  • Edaravone-caffeine combination for the effective management of rotenone induced Parkinson's disease in rats: An evidence based affirmative from a comparative analysis of behavior and biomarker expression.

    abstract::Restoration of cellular microenvironment is important in the treatment of neurodegenerative diseases for optimal functioning and survival of neurons. Oxidative stress has been proposed as one of the major pathogenic drivers in Parkinson's disease. Parkinson's model was developed by chronic administration of a pesticid...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Bandookwala M,Sahu AK,Thakkar D,Sharma M,Khairnar A,Sengupta P

    更新日期:2019-10-15 00:00:00

  • A new mutation in the parkin gene in a patient with atypical autosomal recessive juvenile parkinsonism.

    abstract::We have investigated the presence of mutations in the parkin gene in patients with early-onset parkinsonism. Direct sequencing of the polymerase chain reaction (PCR) products showed a homozygous G deletion in the exon 7 (c.871delG) in one patient. This was a 38-year-old Moroccan woman with a history of parkinsonism of...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Muñoz E,Pastor P,Martí MJ,Oliva R,Tolosa E

    更新日期:2000-07-28 00:00:00

  • MicroRNA-21 attenuates oxygen and glucose deprivation induced apoptotic death in human neural stem cells with inhibition of JNK and p38 MAPK signaling.

    abstract::Neural stem cells (NSCs) persist in the mammalian brain throughout life and protect against hypoxia-ischemia injury. NSCs are being increasingly recognized as a novel therapeutic target for various neurological disorders. Previous research indicates that miR-21 attenuates hypoxia-ischemia induced apoptotic death in va...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Chen R,Tai Y,Zhang Y,Wang L,Yang Y,Yang N,Ma S,Xue F,Wang J

    更新日期:2019-01-18 00:00:00

  • Neuronal nitric oxide synthase inhibition differentially affects oxytocin and vasopressin secretion in salt loaded rats.

    abstract::Nitric oxide, an endogenous gas produced by nitric oxide synthase (NOS), has been described as a neuromodulator of hormone secretion, including the neurohypophysial peptides oxytocin (OT) and vasopressin (AVP), hormones involved in the sodium and water homeostasis. The presence of NOS in the hypothalamic nuclei as wel...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ventura RR,Giusti-Paiva A,Gomes DA,Elias LL,Antunes-Rodrigues J

    更新日期:2005-05-06 00:00:00

  • Distinguishing visuospatial working memory and complex mental calculation areas within the parietal lobes.

    abstract::The present study was aimed at differentiate, within the parietal cortex, the areas underlying visuospatial working memory/attentionnal processes and those devoted to arithmetic processing. We compared, using positron emission tomography, the cerebral networks activated in two groups of subjects, one solving two-by-tw...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Zago L,Tzourio-Mazoyer N

    更新日期:2002-10-04 00:00:00

  • Apelin-immunoreactivity in the rat hypothalamus and pituitary.

    abstract::With the use of an antiserum against human apelin-36, apelin-immunoreactivity (irAP) was detected in neurons and cell processes of the supraoptic nucleus (SO), paraventricular nucleus (PVH), accessory neurosecretory nuclei (Acc) and suprachiasmatic nucleus. Strongly labeled cells/processes were noted in the internal l...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Brailoiu GC,Dun SL,Yang J,Ohsawa M,Chang JK,Dun NJ

    更新日期:2002-07-26 00:00:00

  • Distinct patterns of distribution among NADPH-diaphorase neurones of the guinea pig retina.

    abstract::We have examined the morphology and distribution of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase) cells in the retina of the guinea pig. Two morphologically distinct classes of labelled cells were detected, one with larger, darkly labelled somata commonly located in the inner nuclear layer ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Cobcroft M,Vaccaro T,Mitrofanis J

    更新日期:1989-08-14 00:00:00

  • Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?

    abstract::Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yadlapalli JSK,Dogra N,Walbaum AW,Prather PL,Crooks PA,Dobretsov M

    更新日期:2018-04-23 00:00:00

  • The normal emergence of the superior collicular map of auditory space in the guinea pig following developmental removal of visual cortex.

    abstract::The normal development of the superior collicular map of auditory space in the guinea pig requires visual experience (Eur. J. Neurosci., 2 (1990) 682-692). The possible role of the visual cortex in this process was assessed by unilateral removal of the cortex prior to the crucial period during which visual experience ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Withington DJ,Binns KE,Keating MJ

    更新日期:1991-04-29 00:00:00

  • Involvement of oxidative stress in the rapid Akt1 regulating a JNK scaffold during ischemia in rat hippocampus.

    abstract::It has been well documented that the activation of Akt1 and JNK pathways are involved in the neuronal cell death in cerebral ischemia. In this study, we describe a novel interaction between Akt1 and JNK interacting protein 1 (JIP-1). We first detected the interaction of Akt1 and JIP-1 in hippocampus at various time po...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Pan J,Pei DS,Yin XH,Hui L,Zhang GY

    更新日期:2006-01-09 00:00:00

  • Intracellular amyloid induces impairments on electrophysiological properties of cultured human neurons.

    abstract::The role of intracellular amyloid beta (iAbeta) in Alzheimer's disease (AD) initiation and progression attracts more and more attention in recent years. To address whether iAbeta induces early alterations of electrophysiological properties in cultured human primary neurons, we delivered iAbeta with adeno-virus and mea...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Hou JF,Cui J,Yu LC,Zhang Y

    更新日期:2009-10-25 00:00:00

  • The focus of attention at the virtual cocktail party--electrophysiological evidence.

    abstract::The width of the attentional focus during the selection of one of two concurrent normal human participants was investigated using event-related potentials. Two stories were presented from virtual locations located 15° to the left and right azimuth by convolving the speech message by the appropriate head-related transf...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lambrecht J,Spring DK,Münte TF

    更新日期:2011-02-01 00:00:00

  • Molecular evolution of uncoupling proteins and implications for brain function.

    abstract::Uncoupling proteins (UCPs) belong to the mitochondrial anion carrier superfamily and catalyze important metabolic functions at the mitochondrial inner membrane. While the thermogenic role of UCP1 in brown fat of eutherian mammals is well established, the molecular functions of UCP1 in ectothermic vertebrates and of ot...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审


    authors: Gaudry MJ,Jastroch M

    更新日期:2019-03-23 00:00:00

  • Reciprocal changes in the expression of neurotrophin mRNAs in target tissues and peripheral nerves of aged rats.

    abstract::trk receptors are downregulated in both dorsal root ganglion (DRG) and spinal motoneurons of aged rats with behavioral sensorimotor deficits. Here we provide evidence, using reverse transcription-polymerase chain reaction (RT-PCR), of decreased levels of neurotrophin (nerve growth factor, NGF; brain-derived neurotroph...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ming Y,Bergman E,Edström E,Ulfhake B

    更新日期:1999-10-08 00:00:00

  • Immunocytochemical demonstration of astrocytes and microglia in the whale brain.

    abstract::Whale brains have attracted the attention of neuroscientists but there are only sparse studies on whale glial cells. Here we report on immunolabeling of astrocytes by antibodies to glial fibrillary acidic protein (GFAP) or protein S-100 beta (both by the streptavidin/biotin technique), and labeling of microglial cells...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Pritz-Hohmeier S,Härtig W,Behrmann G,Reichenbach A

    更新日期:1994-02-14 00:00:00

  • Feedback about isometric force production yields more random variations.

    abstract::We investigated the relation between visual feedback and the degree of structure versus randomness in the variability of single-digit, isometric force output. Participants were instructed to maintain a constant level of force during the presence or absence of visual feedback about force output. The structure of force ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Athreya DN,Van Orden G,Riley MA

    更新日期:2012-03-28 00:00:00

  • Human supplementary motor area is active in preparation for both voluntary muscle relaxation and contraction: subdural recording of Bereitschaftspotential.

    abstract::Bereitschaftspotentials (BPs) preceding muscle relaxation and contraction were compared by using subdural electrodes which were implanted onto the right medial frontal surface in two patients with supplementary motor area (SMA) seizure. The applied movement paradigm (muscle relaxation and contraction tasks) was comple...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yazawa S,Ikeda A,Kunieda T,Mima T,Nagamine T,Ohara S,Terada K,Taki W,Kimura J,Shibasaki H

    更新日期:1998-03-20 00:00:00

  • Placebo effects: From pain to motor performance.

    abstract::The placebo effect can be elicited by two main mechanisms: via classical conditioning and cognitive expectations. These two mechanisms have been traditionally investigated in one single domain. The aim of the present study is to investigate how a placebo effect obtained in one modality (pain tolerance) can be transfer...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,随机对照试验


    authors: Carlino E,Guerra G,Piedimonte A

    更新日期:2016-10-06 00:00:00

  • Word-induced postural changes reflect a tight interaction between motor and lexico-semantic representations.

    abstract::A tight coupling between lexico-semantic access and motor control has been established on the basis of neuropsychological, neurophysiological, and behavioral evidence. For example, sensory and motor cortices have been shown to be active when subjects listen to words denoting bodily actions. Kinematic analyses of subje...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Shiller DM,Bourguignon N,Frak V,Nazir T,Cadoret G,Robert M,Lemay M

    更新日期:2013-10-25 00:00:00

  • Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency.

    abstract::Vitamin B12 is implicated in methylation processes. Myelin basic protein is methylated on one arginine group. A defect in methylation could produce an unstable protein, leading to neurological disorders. In order to study myelin basic protein, we have developed the cultures of newborn rat oligodendrocytes in vitamin B...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Sponne IE,Gaire D,Stabler SP,Droesch S,Barbé FM,Allen RH,Lambert DA,Nicolas JP

    更新日期:2000-07-21 00:00:00

  • Internal consistency of dipole localizations for the human movement-evoked magnetic field component 1 (MEF 1).

    abstract::The present magnetoencephalographic study was conducted in order to assess the accuracy of dipole localizations for the movement-evoked field component 1 (MEF 1). Three male subjects were requested to perform self-paced flexions of their index finger and thumb in repeated sessions of 60 trials while the neuromagnetic ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Rosburg T,Weiss T,Haueisen J,Nowak H,Sauer H

    更新日期:1996-08-30 00:00:00

  • The maturation of post-synaptic densities in chicken forebrain.

    abstract::During normal post-hatch development and maturation in chicken forebrain there was a doubling in the average thickness of the post-synaptic densities (PSDs) in isolated synaptosomes, but no change in the average length of synaptic junctions. In the same period the concentration of the major post-synaptic density prote...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Rostas JA,Brent VA,Güldner FH

    更新日期:1984-04-06 00:00:00

  • Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography.

    abstract::The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Sörös P,Knecht S,Bantel C,Imai T,Wüsten R,Pantev C,Lütkenhöner B,Bürkle H,Henningsen H

    更新日期:2001-02-09 00:00:00

  • NMDA receptor dependent changes in c-fos and p-CREB signaling following extinction and reinstatement of morphine place preference.

    abstract::Neural circuitry comprising the ventral tegmental area, nucleus accumbens (NAc), prefrontal cortex (PFC) and hippocampus (HIP) has a main role in reward phenomena. Previous behavioral studies indicated that intracerebroventricular administration of AP5 (NMDA glutamate receptor antagonist) and CNQX (AMPA/kainate glutam...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Siahposht-Khachaki A,Ezzatpanah S,Razavi Y,Haghparast A

    更新日期:2018-01-01 00:00:00

  • Factors in cerebrospinal fluid affecting motor activity in the rat.

    abstract::Cerebrospinal fluid (CSF) was obtained from donor rats either during the dark or during the light period of their diurnal cycle, and infused into the lateral ventricle of recipient rats. Infusing recipient rats during their dark period with CSF from light-exposed donors reduced the motor activity, whereas, conversely,...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Sachs J,Ungar J,Waser PG,Borbély AA

    更新日期:1976-04-01 00:00:00

  • Genetic interaction analysis for DRD4 and DAT1 genes in a group of Mexican ADHD patients.

    abstract::Attention-deficit hyperactivity disorder (ADHD) is a clinically complex and multifactorial psychiatric disorder of inattention, hyperactivity and impulsivity. Family, twin and adoption studies suggest a genetic influence in the etiology of ADHD. Two variable number of tandem repeats (VNTR) polymorphic systems have bee...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Gabriela ML,John DG,Magdalena BV,Ariadna GS,Francisco de LP,Liz SM,Lino PC,Josefina RG,Ernesto RZ,Carlos CF

    更新日期:2009-02-27 00:00:00

  • Epileptiform discharges induced by combined application of bicuculline and 4-aminopyridine are resistant to standard anticonvulsants in slices of rats.

    abstract::Application of 4-aminopyridine (4AP) has previously been reported to produce different patterns of epileptiform discharges in entorhinal cortex-hippocampal-slices. Here we describe that 4-AP induced epileptiform activity in the EC becomes insensitive to anticonvulsant drugs (phenytoin, carbamazepine, valproic acid, ph...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Brückner C,Stenkamp K,Meierkord H,Heinemann U

    更新日期:1999-06-25 00:00:00

  • Changes in c-fos mRNA in the neonatal rat brain following hypoxic ischemia.

    abstract::We used quantitative in situ hybridization to study changes in the expression of c-fos following hypoxic-ischemia (H-I) in the neonatal rat brain. 7-day-old rat pups were subjected to a unilateral ligation of the common carotid artery followed by a 2 h 15 min hypoxic period (7.7% O2 in N2). This resulted in the expect...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Adén U,Bona E,Hagberg H,Fredholm BB

    更新日期:1994-10-24 00:00:00

  • KIBRA gene variants are associated with episodic memory performance in subjective memory complaints.

    abstract::The KIBRA gene encodes a cytoplasmatic protein, a member of the signal transduction protein family, expressed mainly in the brain. Recent studies have implicated the involvement of a genetic variation in the KIBRA gene (T allele) in human memory in normal subjects and in the risk of developing Alzheimer's disease (AD)...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Nacmias B,Bessi V,Bagnoli S,Tedde A,Cellini E,Piccini C,Sorbi S,Bracco L

    更新日期:2008-05-09 00:00:00

  • Dimensions of affective semantic meaning--behavioral and evoked potential correlates in Chinese subjects.

    abstract::The affective meaning of words can be quantified statistically by the 'semantic differential technique'. We studied a total of 55 Chinese adults in two experiments: first, 210 nouns were rated by 32 subjects. Factor analysis on these data yielded three independent semantic dimensions. Semantically unique words were us...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Skrandies W,Chiu MJ

    更新日期:2003-04-24 00:00:00