Abstract:
:The effects of gonadal steroids on serotonin (5-HT) synthesis and metabolism in the early developing brain were investigated. Seven-day-old (7 days post-hatch) tilapia, Oreochromis mossambicus were continuously treated with 17beta-estradiol (E2), methyltestosterone (MT) and para-chlorophenylalanine (p-PCA) up to the age of 30 days. The brain 5-HT content, before 30 days, increased with age. The result indicates that this is a developing period of the central 5-HTergic system. During this developing period, the activity of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO) was not altered by age. Both E2 and MT influence the central 5-HT content during its restricted developmental period. E2 has an initial inhibitory effect and then a facilitative effect while MT only has a facilitative effect. The initial inhibitory effect of E2 is mediated by decreasing TPH activity and increasing MAO activity to decrease the 5-HT content. The facilitative effect of both E2 and MT is suppressed by p-CPA.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tsai CL,Wang LHdoi
10.1016/s0304-3940(99)00160-3keywords:
subject
Has Abstractpub_date
1999-04-02 00:00:00pages
45-8issue
1-3eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00160-3journal_volume
264pub_type
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