The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years.

abstract：:Curcumin is capable of promoting peripheral nerve regeneration in normal condition. However, it is unclear whether its beneficial effect on nerve regeneration still exists under diabetic mellitus. The present study was designed to investigate such a possibility. Diabetes in rats was developed by a single dose of strep...

journal_title：Neuroscience letters

authors： Ma J,Yu H,Liu J,Chen Y,Wang Q,Xiang L

更新日期：2016-01-01 00:00:00

abstract：:Long-term potentiation (LTP) in the dentate gyrus was previously shown to be enhanced by nicotine, an effect dependent on both homomeric α7 and heteromeric α2β2 nicotinic acetylcholine receptors (nAChR). In our experiments, bath-applied nicotine produced no significant enhancement of LTP. The α7 nAChR silent agonist N...

journal_title：Neuroscience letters

authors： Papke RL,Peng C,Kumar A,Stokes C

更新日期：2018-06-11 00:00:00

abstract：:The goal of this study was to examine the coupling between visual information and body sway with binocular and monocular vision at two distances from the front wall of a moving room. Ten participants stood as still as possible inside of a moving room facing the front wall in conditions that combined room movement with...

journal_title：Neuroscience letters

authors： Moraes R,Lopes AG,Barela JA

更新日期：2009-09-04 00:00:00

abstract：:We show that people continuously react to time perturbations in the range 3-96 ms in otherwise isochronous sound sequences. Musically trained and untrained participants were asked to synchronize with a sequence of sounds, and these two groups performed almost equally below the threshold for conscious detection of the ...

journal_title：Neuroscience letters

authors： Madison G,Merker B

更新日期：2004-11-03 00:00:00

abstract：:It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D...

journal_title：Neuroscience letters

authors： Boccardi M,Almici M,Bresciani L,Caroli A,Bonetti M,Monchieri S,Gennarelli M,Frisoni GB

更新日期：2010-01-04 00:00:00

abstract：:Caffeine is a widely consumed substance that elicits psychomotor stimulant effects and also displays addictive properties. In order to assess the effect of caffeine on striatal neuropeptide mRNA expression, male rats were injected (i.p.) with caffeine at 20, 40 or 80 mg/kg of body weight twice daily for 9 consecutive ...

journal_title：Neuroscience letters

authors： Datta U,Noailles PA,Kraft M,Zhang Y,Angulo JA

更新日期：1997-08-01 00:00:00

abstract：:Isolated Helix neurons were internally perfused under voltage-clamp, with drugs applied by the 'concentration clamp' which allowed an extremely rapid switching of the external solution. 4-Aminopyridine (4-AP) at more than 3 X 10(-4) M induced a chloride current (ICl) which could be blocked by D-tubocurarine. Acetylcho...

journal_title：Neuroscience letters

authors： Ikemoto Y,Akaike N,Ono K

更新日期：1987-04-23 00:00:00

abstract：:Galantamine, which is currently used in the treatment of patients with Alzheimer's disease (AD), has been shown to have a neuroprotective effect against beta-amyloid (Abeta) peptide-induced toxicity, which is involved in the pathogenesis of AD. In this study, we investigated the mechanism underlying the protective eff...

journal_title：Neuroscience letters

authors： Li Q,Fang J,Yang M,Wu D,Zhang L,Zhang Y

更新日期：2010-08-23 00:00:00

abstract：:Beta,beta'-Iminodipropionitrile (IDPN) is known to produce a massive accumulation of neurofilaments in the proximal portion of axons of spinal anterior horn cells. The spinal cords of 20 Wistar rats treated with IDPN were examined immunohistochemically with a monoclonal antibody against heparan sulfate (HepSS-1). Virt...

journal_title：Neuroscience letters

authors： Wada M,Kato T,Kurita K,Shikama Y,Toyoshima I,Sasaki H

更新日期：1995-12-29 00:00:00

abstract：:We previously demonstrated the preventive effect of insulin-like growth factor 1 (IGF-1) on steroid myopathy in rats. However, the mechanism by which IGF-1 inhibits steroid myopathy remains unclear. Recent studies have revealed that glutamine synthetase (GS) is induced by glucocorticoid and may be related to the devel...

journal_title：Neuroscience letters

authors： Kimura K,Kanda F,Okuda S,Chihara K

更新日期：2001-04-20 00:00:00

abstract：:Synaptic plasticity in olfactory inputs to the lateral entorhinal cortex may result in lasting changes in the processing of olfactory stimuli. Changes in dopaminergic tone can have strong effects on basal evoked synaptic responses in the superficial layers of the entorhinal cortex, and the current study investigated w...

journal_title：Neuroscience letters

authors： Caruana DA,Reed SJ,Sliz DJ,Chapman CA

更新日期：2007-10-09 00:00:00

abstract：:Tobacco smoke inhibits monoamine oxidase-B (MAO-B) activity in vitro and in vivo, suggesting that MAO-B inhibition is a possible contributing factor to tobacco smoke addiction. Thus, MAO-B is a possible candidate gene for predisposition to smoking. The TaqIB polymorphism for the Dopamine D2 Receptor gene (DRD2) has be...

journal_title：Neuroscience letters

authors： Costa-Mallen P,Costa LG,Checkoway H

更新日期：2005-09-09 00:00:00

abstract：:Neurons of the lateral olivocochlear (LOC) system project from the auditory brainstem to the cochlea, where they synapse on radial dendrites of auditory nerve fibers. Selective LOC disruption depresses sound-evoked auditory nerve activity in the guinea pig, but enhances it in the mouse. Here, LOC disruption depressed ...

journal_title：Neuroscience letters

authors： Le Prell CG,Dolan DF,Hughes LF,Altschuler RA,Shore SE,Bledsoe SC Jr

更新日期：2014-10-17 00:00:00

abstract：:Parkin Co-Regulated Gene (PACRG) is a gene that shares a bi-directional promoter with the Parkinson's disease associated gene parkin. The functional role of PACRG is not well understood, although the gene has been associated with parkinsonian syndromes and more recently with eukaryotic cilia and flagella. We investiga...

journal_title：Neuroscience letters

authors： Wilson GR,Tan JT,Brody KM,Taylor JM,Delatycki MB,Lockhart PJ

更新日期：2009-08-21 00:00:00

abstract：:The effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a specific non-N-methyl-D-aspartate (non-NMDA) receptor antagonist, on NMDA-independent epileptiform activity induced by Mg2(+)-free medium was studied in rat basolateral amygdala (BLA) neurons using intracellular recording techniques. Twenty to 30 min after s...

journal_title：Neuroscience letters

authors： Gean PW

更新日期：1990-10-30 00:00:00

abstract：:Human amniotic epithelial (HAE) cells have been used for allotransplantation in patients with lysosomal storage disease due to lack of expression of HLA antigens. Previously, we have reported the expression of differentiation markers for both neural stem cells, and neuron and glial cells. In the present study, we inve...

journal_title：Neuroscience letters

authors： Sakuragawa N,Misawa H,Ohsugi K,Kakishita K,Ishii T,Thangavel R,Tohyama J,Elwan M,Yokoyama Y,Okuda O,Arai H,Ogino I,Sato K

更新日期：1997-08-22 00:00:00

abstract：:Age dependent EEG signatures were detected in the EEG of 71 neonates of 28-100 weeks of conceptional age (CA). Using the new method presented, neonates were automatically classified in three age groups (28-35 weeks CA), (36-40 weeks CA) and (41-100 weeks CA). Analysis was performed employing relative distance function...

journal_title：Neuroscience letters

authors： Holthausen K,Breidbach O,Scheidt B,Frenzel J

更新日期：1999-06-25 00:00:00

abstract：:The density of hippocampal adenosine A1 receptors was measured in autopsy samples of six patients with dementia with either Alzheimer (three) or sclerosis type pathology (three) in hippocampus and six control patients. Kinetic parameters (Bmax and KD) were determined by means of quantitative autoradiography using [3H]...

journal_title：Neuroscience letters

authors： Deckert J,Abel F,Künig G,Hartmann J,Senitz D,Maier H,Ransmayr G,Riederer P

更新日期：1998-03-06 00:00:00

abstract：:Mitochondrial Ca(2+) controls numerous cell functions, such as energy metabolism, reactive oxygen species generation, spatiotemporal dynamics of Ca(2+) signaling, cell growth and death in various cell types including neurons. Mitochondrial Ca(2+) accumulation is mainly mediated by the mitochondrial Ca(2+) uniporter (M...

journal_title：Neuroscience letters

authors： Jakob R,Beutner G,Sharma VK,Duan Y,Gross RA,Hurst S,Jhun BS,O-Uchi J,Sheu SS

更新日期：2014-07-11 00:00:00

abstract：:Thoracolumbar and lumbosacral spinal segments that receive afferent input from the descending colon and rectum were stained immunocytochemically for c-Fos- and c-Jun-like proteins following repetitive, noxious colorectal distention (CRD). Noxious CRD (80 mmHg) resulted in significantly more c-Fos- and c-Jun-like immun...

journal_title：Neuroscience letters

authors： Traub RJ,Herdegen T,Gebhart GF

更新日期：1993-10-01 00:00:00

abstract：:The regional distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, was compared to the regional distribution of receptors labeled by [3H]SCH 23390 and [3H]sulpiride, [3H]SCH 23390 and [3H]sulpiride labeled distinct nuclei, such as the olfactory tubercle, caudate, globus pall...

journal_title：Neuroscience letters

authors： Contreras PC,Quirion R,Gehlert DR,Contreras ML,O'Donohue TL

更新日期：1987-03-31 00:00:00

abstract：:A fundamental question in human sexuality regards the neural substrate underlying sexually-arousing representations. Lesion and neuroimaging studies suggest that dorsolateral pre-frontal cortex (DLPFC) plays an important role in regulating the processing of visual sexual stimulation. The aim of this Functional Near-In...

journal_title：Neuroscience letters

authors： Leon-Carrion J,Martín-Rodríguez JF,Damas-López J,Pourrezai K,Izzetoglu K,Barroso Y Martin JM,Dominguez-Morales MR

更新日期：2007-04-06 00:00:00

abstract：:Expiratory only resistive loaded breathing (RL) reduces high energy electromyogram (EMG) power (EH) during an isometric contraction of a leg extensor muscle, but not an arm flexor. An interaction between afferent activity during expiratory RL and inspiratory non-loaded phases of breathing, which the contraction spanne...

journal_title：Neuroscience letters

authors： Turner D,Sumners P,Jackson S

更新日期：2000-12-15 00:00:00

abstract：:The effect of different frequencies of music on brain function was investigated through measurement of blood pressure in spontaneously hypertensive rats (SHR). Previous studies indicated that exposure to Mozart's music (K. 205) leads to increased calcium/calmodulin-dependent dopamine synthesis in the brain, and that t...

journal_title：Neuroscience letters

authors： Akiyama K,Sutoo D

更新日期：2011-01-03 00:00:00

abstract：:Activation of serotonin (5-hydroxytryptamine, 5-HT) receptors produces various autonomic and neuroendocrine responses in the hypothalamic paraventricular nucleus (PVN), including increased blood pressure and heart rate. However, the role(s) of 5-HT on the local GABA synaptic circuit have not been well understood in th...

journal_title：Neuroscience letters

authors： Lee KS,Han TH,Jo JY,Kang G,Lee SY,Ryu PD,Im JH,Jeon BH,Park JB

更新日期：2008-07-11 00:00:00

abstract：:Excitotoxin lesion of nucleus basalis with kainate or ibotenate results in degeneration of cholinergic neurones and a subsequent cholinergic deficit in cerebral cortex ipsilateral to the lesion. This lesion is accompanied by a massive increase in ornithine decarboxylase (ODC) activity in ipsilateral cortex, which was ...

journal_title：Neuroscience letters

authors： Wood H,de Belleroche J

更新日期：1990-03-26 00:00:00

abstract：:Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as c...

journal_title：Neuroscience letters

authors： Shibata N,Kawarai T,Lee JH,Lee HS,Shibata E,Sato C,Liang Y,Duara R,Mayeux RP,St George-Hyslop PH,Rogaeva E

更新日期：2006-01-02 00:00:00

abstract：:In man, an anesthetic agent that induces surgical anesthesia with minimal influence on descending pyramidal tract activity remains to be found. Anesthesia with ketamine allows recording of stable compound muscle action potentials (CMAPs) to single transcranial magnetic stimulations of the motor cortex (CortStim) in mo...

journal_title：Neuroscience letters

authors： Kothbauer K,Schmid UD,Liechti S,Rösler KM

更新日期：1993-05-14 00:00:00

abstract：:A hybridoma cell line secreting a monoclonal antibody against catalytic subunits of acetylcholinesterase in the electric organ of Narke japonica has been obtained by using a mouse immunized with the nerve terminal membranes prepared from the electric organ of Narke japonica. This monoclonal antibody (Nj-501) reacted w...

journal_title：Neuroscience letters

authors： Abe T,Sakai M,Saisu H

更新日期：1983-07-15 00:00:00

abstract：:Central administration of C-type natriuretic peptide (CNP) affects various neuroendocrine systems. In the present study, we examined whether CNP acts directly on arginine-vasopressin (AVP) secretion from rat supraoptic nucleus (SON) neurons, using acute dissociated cell preparations. CNP inhibited the basal secretion ...

journal_title：Neuroscience letters

authors： Yamamoto S,Morimoto I,Yanagihara N,Kangawa K,Inenaga K,Eto S,Yamashita H

更新日期：1997-06-27 00:00:00