Abstract:
:The regional distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, was compared to the regional distribution of receptors labeled by [3H]SCH 23390 and [3H]sulpiride, [3H]SCH 23390 and [3H]sulpiride labeled distinct nuclei, such as the olfactory tubercle, caudate, globus pallidus, substantia nigra, and inferior and superior colliculi. In contrast, the distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, were much more extensive. Some areas containing the highest density of sites labeled by [3H]haloperidol were the external plexiform layer of the olfactory bulb, the cerebral cortex, the paraventricular nuclei, the interpeduncular nucleus and the superior colliculus. The distribution of non-dopaminergic binding sites labeled by haloperidol was clearly quite different from that labeled by dopaminergic ligands.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Contreras PC,Quirion R,Gehlert DR,Contreras ML,O'Donohue TLdoi
10.1016/0304-3940(87)90286-2subject
Has Abstractpub_date
1987-03-31 00:00:00pages
133-40issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90286-2journal_volume
75pub_type
杂志文章abstract::Physical exercise-induced inflammation may be beneficial when exercise is regular but it may be harmful when exercise is intense and performed by unaccustomed individuals/rats. Molecular hydrogen (H2) has recently emerged as a powerful anti-inflammatory, antioxidant and anti-apoptotic molecule in a number of pathologi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2019.134577
更新日期:2020-01-10 00:00:00
abstract::To investigate whether there is a descending contribution to the spinal 5-hydroxytryptamine (5-HT) innervation in the lamprey, a primitive vertebrate, a study using retrograde transport of the fluorescent tracer Fast blue combined with 5-HT immunohistochemistry was conducted. Two to 4 weeks after an injection of Fast ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90207-7
更新日期:1986-06-06 00:00:00
abstract::When standing quietly, human upright stance is typically approximated as a single segment inverted pendulum. In contrast, investigations which perturb upright stance with support surface translations or visual driving stimuli have shown that the body behaves like a two-segment pendulum, displaying both in-phase and an...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.11.071
更新日期:2005-03-29 00:00:00
abstract::Mitochondrial dysfunction and oxidative stress are often linked to various neurodegenerative disorders including ischemic stroke and Huntington's disease (HD). S-Nitrosoglutathione (GSNO) is an endogenous nitric oxide carrier recently identified as a potent antioxidant capable of neutralizing oxidative stress. In the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.03.028
更新日期:2004-05-27 00:00:00
abstract::The bradykinin B2 receptor (B2R) mediates many physiological processes such as hypotension, inflammation and blood-vessel permeability. Hypoxia/reoxygenation (H/R) induces neuronal cell apoptosis. It was found that B2R expression was enhanced in primary cultured cortical neurons after H/R treatment. Addition of bradyk...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.10.110
更新日期:2009-01-23 00:00:00
abstract::We describe the incidence of gamma-aminobutyric acid (GABA)ergic neurons after post-embedding immunocytochemistry on semithin sections of the claustrum, putamen and lateral, dorsal and medial cortical areas. Twelve percent of the neurons counted in the claustrum of 11 rabbits were GABAergic. This incidence was signifi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)00889-2
更新日期:2000-03-24 00:00:00
abstract::Traumatic brain injury (TBI) represents a major cause of long-term disability worldwide. Primary damage to brain tissue leads to complex secondary injury mechanisms involving inflammation, oxidative stress and cellular activation/reactivity. The molecular pathways that exacerbate brain cell dysfunction after injury ar...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.135405
更新日期:2020-11-20 00:00:00
abstract::In an isolated preparation which consists of the buccal ganglia and the salivary nerve of Helix lucorum, neuron B2 can be identified by simultaneously recording the soma spike intracellularly and the axon spike extracellularly from the peripheral salivary nerve. The convulsant drug pentylenetetrazol (PTZ) eliminates t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00382-1
更新日期:1999-06-18 00:00:00
abstract::An abnormal distribution of phosphorylated neurofilaments is present in some human neurodegenerative disorders including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. This study reports the changes of phosphorylated neurofilaments observed in rat spinal cord after intrathecal injection o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(90)90751-t
更新日期:1990-10-30 00:00:00
abstract::Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, has been developed as a drug to be used for treatment of stroke for hundreds of years. However, the underlying mechanisms remain unknown. In the present study, the effects of BYHWD on delayed neuronal death of hippocampus after transient forebrain ischem...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00522-6
更新日期:2003-07-31 00:00:00
abstract::To clarify the psychopharmacological profile of blonanserin, a novel antipsychotic, we examined its effect on the methamphetamine-induced disruption of latent inhibition (LI) and the neural activation related to this effect in rats. To evaluate the LI, we used a conditioned emotional response in which a tone (conditio...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.06.020
更新日期:2013-08-09 00:00:00
abstract::Intra-arterial (i.a.) injection of Indian red scorpion (Mesobuthus tamulus; BT) venom produces cardiorespiratory changes by involving perivascular receptors. The afferents involved in mediating these reflex responses are not known. The present investigation was conducted to examine the afferents mediating the vasosens...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.04.037
更新日期:2008-06-13 00:00:00
abstract::Differential performance over a wide range of possible postural coordination modes was investigated using 16 ankle-hip relative phase patterns from 0 degrees to 337.5 degrees. Participants were instructed to produce each coordination mode with and without real time visual feedback. Feedback consisted of a Lissajous fi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.10.043
更新日期:2005-02-10 00:00:00
abstract::The noradrenergic system modulates attention and arousal. Dysregulation of the noradrenergic system may be involved in the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). This study intended to examine the differences in methylphenidate (MPH) treatment response and pre- and post-treatment cerebral ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.02.079
更新日期:2012-04-18 00:00:00
abstract::Miyoshi myopathy (MM) is an autosomal recessive distal muscular dystrophy caused by mutations in the dysferlin gene (DYSF), a 150-kb gene on chromosome 2p13 that contains 55 coding exons. Many patients with MM harbour mutations in the DYSF gene, and most of these mutations are inherited from the patients' parents. Rec...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.10.048
更新日期:2018-01-18 00:00:00
abstract:BACKROUND:8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurod...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.09.048
更新日期:2018-01-01 00:00:00
abstract::The effects of severe hypoglycemia on perforant path-evoked field potentials were examined in the rat hippocampus. Although a complete loss of this response was noted when blood glucose concentration fell below 1 mM, this occurred before cessation of electroencephalogram (EEG) activity. Both spontaneous and evoked res...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90418-6
更新日期:1987-05-19 00:00:00
abstract::Face processing is unique to human beings and is likely to have special neuronal properties. We studied one of these properties, categorical representation of the face in perception processing (perception) and in memory recall processing (imagery), using the face and building stimuli. The same building-selective areas...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.09.053
更新日期:2008-12-19 00:00:00
abstract::Selective injection of horseradish peroxidase (HRP) into the left and median lobes (LM) and into the right and caudate (RC) lobes of the liver is followed by labeling of neuronal somata in the right and left nodose ganglia. The size distribution of the labeled neuronal population shows that the afferent neurons from t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90364-7
更新日期:1985-12-04 00:00:00
abstract::Exposure to morphine during pregnancy produced long-term effects in offspring behaviors. Recent studies have shown that voluntary exercise decreases the severity of anxiety behaviors in both morphine-dependent and withdrawn rats. Thus, the aims of the present study were to examine whether maternal exercise decreases p...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.06.026
更新日期:2014-08-22 00:00:00
abstract::Drug addiction is a process that transits from recreative and regular drug use into compulsive drug use. The two patterns of drug use, controlled drug intake and escalated drug intake, represent different stages in the development of drug addiction; and escalation of drug use is a hallmark of addiction. Accumulating s...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.11.016
更新日期:2016-01-12 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by selective atrophy of frontal and temporal lobes. Over the years, however...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2016.09.007
更新日期:2017-01-01 00:00:00
abstract::Rhythmic arm movement significantly suppresses H-reflex amplitude in the soleus (SOL) muscle. This is evidence of neural linkages between the arms and legs which can be exploited during locomotion and have been ascribed to the descending effects of CPGs for arm cycling. However, the generalizability of the effects of ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.11.034
更新日期:2009-02-06 00:00:00
abstract::Single units have been recorded extracellularly from the periaqueductal central grey and from adjacent structures in behaving rats during tail flick reflexes elicited by controlled radiant heat. Together with the spike recordings, the heart rate of the animal and a thoracic myogram as an indicator of overall motor act...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(82)90016-7
更新日期:1982-05-17 00:00:00
abstract::Muscle fatigue is known to be associated with a deteriorated muscle coordination and impaired movement performance in variety of voluntary movements. The aim of this study was to investigate the generally underexplored effect of muscle fatigue on both the coordination between grip force (GF; the force component perpen...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.07.008
更新日期:2013-08-29 00:00:00
abstract::A prevailing hypothesis is that neurogenesis is reduced in depression and that the common mechanism for antidepressant treatments is to increase it in adult hippocampus. Reduced neurogenesis has been shown in healthy rats exposed to stress, but it has not yet been demonstrated in depressed patients. Emerging studies n...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.12.046
更新日期:2009-02-20 00:00:00
abstract::We assess in mice, the electrophysiological criteria developed in humans and rats in vivo for unmyelinated (C) fibre differentiation into sub-classes, derived from the activity-induced latency increase ("slowing") in response to electrical stimulation during 6 min at 0.25 Hz followed by 3 min at 2 Hz. Fibres are consi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.02.057
更新日期:2015-04-10 00:00:00
abstract::A modified "cross-modal delayed response" paradigm was used to investigate putative processing of face expression in the absence of focused attention to the face. Neutral, happy and sad faces were presented during intervals occurring between a tone and a response imperative signal (a faint click), while subjects were ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.09.081
更新日期:2006-12-20 00:00:00
abstract::Spinal cord injury (SCI) triggers pronounced inflammatory responses that are accompanied by neuronal disruption and functional deficits. SCI treatment remains an unmet clinical need. Emerging evidence suggests that riluzole may exert a neuroprotective effect due to its anti-inflammatory properties. However, details of...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.134829
更新日期:2020-04-01 00:00:00
abstract::The effect of dopamine on the 3',5'-cyclic adenosine monophosphate (cAMP) generating system of membrane particles of rat prostate gland was studied. Dopamine increased the concentration of cAMP in a dose-dependent manner. The selective D1 receptor inhibitor SCH 23390 caused a decrease in dopamine-elicited cAMP levels....
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90608-2
更新日期:1987-06-01 00:00:00