Autoradiographic distribution of non-dopaminergic binding sites labeled by [3H]haloperidol in rat brain.

Abstract:

:The regional distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, was compared to the regional distribution of receptors labeled by [3H]SCH 23390 and [3H]sulpiride, [3H]SCH 23390 and [3H]sulpiride labeled distinct nuclei, such as the olfactory tubercle, caudate, globus pallidus, substantia nigra, and inferior and superior colliculi. In contrast, the distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, were much more extensive. Some areas containing the highest density of sites labeled by [3H]haloperidol were the external plexiform layer of the olfactory bulb, the cerebral cortex, the paraventricular nuclei, the interpeduncular nucleus and the superior colliculus. The distribution of non-dopaminergic binding sites labeled by haloperidol was clearly quite different from that labeled by dopaminergic ligands.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Contreras PC,Quirion R,Gehlert DR,Contreras ML,O'Donohue TL

doi

10.1016/0304-3940(87)90286-2

subject

Has Abstract

pub_date

1987-03-31 00:00:00

pages

133-40

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90286-2

journal_volume

75

pub_type

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