Abstract:
:To investigate whether there is a descending contribution to the spinal 5-hydroxytryptamine (5-HT) innervation in the lamprey, a primitive vertebrate, a study using retrograde transport of the fluorescent tracer Fast blue combined with 5-HT immunohistochemistry was conducted. Two to 4 weeks after an injection of Fast blue into the rostral spinal cord, retrogradely labelled cells were seen throughout the brainstem. Two groups of these cells, one within the posterior reticular nucleus of the rhombencephalon and another rostral to the trigeminal motor nucleus, were labelled after incubation with 5-HT antiserum. These findings suggest that in addition to the well-described local intraspinal 5-HT system, there is also, as in higher vertebrates, a descending 5-HT projection from the brainstem which extends at least 20 segments into the spinal cord.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Brodin L,Buchanan JT,Hökfelt T,Grillner S,Verhofstad AAdoi
10.1016/0304-3940(86)90207-7subject
Has Abstractpub_date
1986-06-06 00:00:00pages
53-7issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(86)90207-7journal_volume
67pub_type
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