Abnormal distribution of phosphorylated neurofilaments in neuronal degeneration induced by kainic acid.

abstract：:We aimed to evaluate the effects of l-dopa use on apparent diffusion coefficient (ADC) values of different brain regions in Parkinson's disease (PD) patients. Thirty-five subjects underwent magnetic resonance imaging (MRI), including 21 PD patients (13 men, 8 women; mean age, 63 years+/-8), and 14 sex and age-matched ...

journal_title：Neuroscience letters

authors： Degirmenci B,Yaman M,Haktanir A,Albayrak R,Acar M,Caliskan G

更新日期：2007-04-18 00:00:00

abstract：:Bax, a pro-apoptotic member of Bcl-2 family proteins, plays a central role in mitochondria-dependent apoptosis. Bax normally resides in the cytosol in a quiescent state. Bax-inhibiting peptide (BIP) is a membrane permeable peptide comprised of five amino acids designed from the Bax-binding domain of Ku70 [M. Sawada, P...

journal_title：Neuroscience letters

authors： Qin Q,Patil K,Sharma SC

更新日期：2004-11-30 00:00:00

abstract：:Interleukin-18 (IL-18) is a pro-inflammatory cytokine and an important mediator of peripheral inflammation and host immune response. IL-18 functions through its binding with the IL-18 receptor (IL-18R), which consists of two chains, an IL-18-binding α chain (IL-18Rα) and a signaling β chain. IL-18 and IL-18R are expre...

journal_title：Neuroscience letters

authors： Kuwahara-Otani S,Maeda S,Kobayashi K,Minato Y,Tanaka K,Yamanishi K,Hata M,Li W,Hayakawa T,Noguchi K,Okamura H,Yagi H

更新日期：2017-05-22 00:00:00

abstract：:Three variations of the in vitro neonatal rat spinal cord preparation were used to investigate motor responses to stimulation of the ventrolateral funiculus (VLF). In a partially hemisected spinal cord preparation, stimuli elicited frequency-dependent activity in lumbar ventral roots that outlasted the stimulus train ...

journal_title：Neuroscience letters

authors： Magnuson DS,Schramm MJ,MacLean JN

更新日期：1995-06-09 00:00:00

abstract：:Preconditioning increases the neurons' resistance to subsequent hypoxia. An in vitro study was conducted to explore kinetic aspects of hypoxic preconditioning. Hippocampal slices were exposed to one single or repeated episodes of oxygen and glucose deprivation (OGD). The interval between OGD episodes varied between 30...

journal_title：Neuroscience letters

authors： Brödemann R,Peters B,Höllt V,Becker A

更新日期：2014-01-13 00:00:00

abstract：:Self-initiated leg movement in standing humans is preceded by a medio-lateral preparatory balance adjustment (PBA); however, such preparatory balance control is often absent in reflex-like stepping responses evoked by whole-body instability. The presence or absence of the PBA may reflect a task-dependent modulation of...

journal_title：Neuroscience letters

authors： McIlroy WE,Bent LR,Potvin JR,Brooke JD,Maki BE

更新日期：1999-06-04 00:00:00

abstract：:LHRH administration is reported to facilitate male sexual behavior. The aim of the present study was to investigate whether male sexual behavior is associated with the number of LHRH neurons in the forebrain in middle-aged rats. Male Long-Evans rats (18-19 months) were assigned to three groups on the basis of sexual p...

journal_title：Neuroscience letters

authors： Tsai YF,Tsai HW,Tai MY,Huang RL,Peng MT

更新日期：1997-11-21 00:00:00

abstract：:Coenzyme Q(10) (CoQ(10)) exerts neuroprotective effects in several in vivo and in vitro models of neurodegenerative disorders. However, the mechanisms of action are not fully understood. The aim in this study was to investigate whether oral administration of CoQ(10) could inhibit cytochrome c (cyt c) release from mito...

journal_title：Neuroscience letters

authors： Mitsumoto Y,Kobayashi S,Matsushima H,Muroyama A,Yoshimura I

更新日期：2009-09-29 00:00:00

abstract：:The structural specificity of alpha-PMTX, a novel peptide toxin derived from wasp venom has been studied on the neuromuscular synapse in the walking leg of the lobster. alpha-PMTX is known to induce repetitive action potentials in the presynaptic axon due to sodium channel inactivation. We synthesized 29 analogs of al...

journal_title：Neuroscience letters

authors： Konno K,Hisada M,Naoki H,Itagaki Y,Yasuhara T,Nakata Y,Miwa A,Kawai N

更新日期：2000-05-05 00:00:00

abstract：:Distributions of 25 motor axons to 60 intrafusal muscle fibers of 10 poles of monkey spindle were reconstructed from serial 1 micron thick transverse sections of lumbrical muscles. About 44% of motor axons co-innervated two or more types of intrafusal fiber. The (dynamic) bag1 fiber shared motor innervation with the (...

journal_title：Neuroscience letters

authors： Kucera J

更新日期：1985-01-07 00:00:00

abstract：:Oxidative damage induced-mitochondrial dysfunction and apoptosis has been widely studied in spinal cord injury (SCI). Lycopene, a polyunsaturated hydrocarbon, has the highest antioxidant capacity compared to the other carotenoids. However, the role of lycopene in SCI is unknown. In the present study, we evaluated the ...

journal_title：Neuroscience letters

authors： Hu W,Wang H,Liu Z,Liu Y,Wang R,Luo X,Huang Y

更新日期：2017-03-06 00:00:00

abstract：:Gamma-band oscillations are related to sensory information processing and attention. To further illuminate the relationship of gamma-band activity and selective somatic attention, we have studied the effects of direction of attention on the stimuli of somatosensory evoked potentials. Responses during focused attention...

journal_title：Neuroscience letters

authors： Gobbelé R,Waberski TD,Schmitz S,Sturm W,Buchner H

更新日期：2002-07-12 00:00:00

abstract：:The influence of testosterone on the postnatal development of reflex electromyographic (EMG) jaw muscle activity evoked by injection of mustard oil (MO) into the temporomandibular joint region and the later recurrence of this EMG activity after intravenous injection of naloxone, was studied in male rats. MO-evoked EMG...

journal_title：Neuroscience letters

authors： Seo K,Fujiwara N,Cairns BE,Someya G

更新日期：2002-12-25 00:00:00

abstract：:This study tested the hypothesis that cholinoceptive regions of the medial pontine reticular formation (mPRF), long known to play a role in regulating the sleep cycle, can also causally alter the respiratory cycle. In 4 cats, sleep and wakefulness were polygraphically recorded while simultaneous measures were taken of...

journal_title：Neuroscience letters

authors： Lydic R,Baghdoyan HA

更新日期：1989-07-31 00:00:00

abstract：:Blood-brain barrier (BBB) is known to be structured with astroglial cells (AGs) and brain endothelial cells (BECs), and it has been proposed that these cells play different roles in the BBB. We cultivated AGs and BECs from infant rats (2-week-old), and these cells were cultured on the opposing side of collagen membran...

journal_title：Neuroscience letters

authors： Kondo T,Kinouchi H,Kawase M,Yoshimoto T

更新日期：1996-04-19 00:00:00

abstract：:We have previously shown that glycine binding sites on presynaptic NMDA receptors (NMDA-Rs) can tonically regulate glutamate release in the rat visual cortex. In the present study, we investigated the subunit composition of these presynaptic NMDA-Rs. We recorded miniature a-amino-3-hydroxy-5-methyl-4-isoxazolepropioni...

journal_title：Neuroscience letters

authors： Li YH,Han TZ,Meng K

更新日期：2008-02-27 00:00:00

abstract：:Using immunohistochemistry we studied the presence of calbindin in myenteric neurones of the guinea-pig stomach. A rabbit anti recombinant rat calbindin-D28k (CALB) stained 12, 12 and 25% of all myenteric neurones in the fundus, corpus and antrum, respectively. A rabbit anti recombinant human CALB stained 4, 4 and 16%...

journal_title：Neuroscience letters

authors： Reiche D,Pfannkuche H,Michel K,Hoppe S,Schemann M

更新日期：1999-07-30 00:00:00

abstract：:gamma-Aminobutyric acid-transaminase (GABA-T) plays an important role in the metabolism of GABA, particularly in the neurons or glial cells. The present study was undertaken to determine the alteration of GABA-T expression in the gerbil hippocampus after ischemia-reperfusion. In the sham, GABA-T(+) neurons were scatte...

journal_title：Neuroscience letters

authors： Kang TC,Park SK,Bahn JH,Chang JS,Koh WS,Jo SM,Cho SW,Choi SY,Won MH

更新日期：2000-11-10 00:00:00

abstract：:Arterial pressure (AP) is known to fluctuate during parabolic-flight-induced gravitational changes in human subjects, increasing during hypergravity and decreasing during microgravity. In this study, we examined whether the vestibular system participates in the AP response to the gravitational changes induced by parab...

journal_title：Neuroscience letters

authors： Iwata C,Abe C,Tanaka K,Morita H

更新日期：2011-05-16 00:00:00

abstract：:The N-Methyl-D-Aspartate Receptors (NMDARs) are heteromeric cation channels involved in learning, memory, and synaptic plasticity, and their dysregulation leads to various neurodegenerative disorders. Recent evidence has shown that apart from the GluN1/GluN2A and GluN1/GluN2B diheteromeric ion channels, the NMDAR also...

journal_title：Neuroscience letters

authors： Cheriyan J,Balsara RD,Hansen KB,Castellino FJ

更新日期：2016-03-23 00:00:00

abstract：:Recent findings from our and other laboratories indicate that cell cycle-related phenomena may play a key role in the formation of Alzheimer-type pathology and neuronal cell death in both Alzheimer's and cerebro-vascular diseases. In this study we examine the expression patterns of cyclins A, B1, D1 and E in neuronal ...

journal_title：Neuroscience letters

authors： Smith MZ,Nagy Z,Esiri MM

更新日期：1999-08-13 00:00:00

abstract：:Exposure to a single session of intense inescapable stressors results in elevations of plasma corticosterone levels selective to the trough of the circadian rhythm that last for several days after stressor cessation. In the present study, we examined whether this stress-induced alteration in the regulation of the circ...

journal_title：Neuroscience letters

authors： Moldow RL,Beck KD,Weaver S,Servatius RJ

更新日期：2005-02-01 00:00:00

abstract：:The present study investigated one of the characteristics of No-go-related brain activity during somatosensory Go/No-go paradigms, by manipulating the stimulus site and response hand. Somatosensory event-related potentials (ERPs) were recorded in ten right-handed subjects. Electrical stimulation was delivered to the s...

journal_title：Neuroscience letters

authors： Nakata H,Sakamoto K,Kakigi R

更新日期：2010-07-12 00:00:00

abstract：:A monoclonal antibody that reacts with a mid rod fragment of dystrophin was used to localize this protein in the central nervous system (CNS). Due to a low abundance of dystrophin in the CNS, an immunoperoxidase reaction amplified with a biotin-avidin system was used. All Purkinje cells in normal mice were dystrophin ...

journal_title：Neuroscience letters

authors： Huard J,Tremblay JP

更新日期：1992-03-16 00:00:00

abstract：:During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5 degrees C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos in...

journal_title：Neuroscience letters

authors： Bitting L,Sutin EL,Watson FL,Leard LE,O'Hara BF,Heller HC,Kilduff TS

更新日期：1994-01-03 00:00:00

abstract：:Parkinson's disease (PD), caused by the decreased number of dopaminergic neurons in the substantia nigra, is identified as the second most familiar age-dependent neurodegenerative disease to the public. Long non-coding RNAs (lncRNAs) have been reported to participate in the development of PD. In our research, the expr...

journal_title：Neuroscience letters

authors： Xie Y,Zhang S,Lv Z,Long T,Luo Y,Li Z

更新日期：2021-01-06 00:00:00

abstract：:The role of the serotonergic system in regulating the expression of estrogen receptor (ER) α in the hypothalamus was investigated in ovariectomized rats by injecting a serotonin synthesis inhibitor, parachlorophenylalanine (PCPA), or by destroying the dorsal raphe nucleus (DR). The number of ERα-immunoreactive (ir) ce...

journal_title：Neuroscience letters

authors： Ito H,Shimogawa Y,Kohagura D,Moriizumi T,Yamanouchi K

更新日期：2014-11-07 00:00:00

abstract：:To investigate whether the xenon-induced inhibition of the transient receptor potential vanilloid type 1 (TRPV1) ion channel in rat dorsal root ganglion (DRG) neurons reduces nociceptive processing, we examined the effect of xenon in reducing the release of calcitonin gene-related peptide (CGRP) from those neurons. We...

journal_title：Neuroscience letters

authors： Calcott G,White JP,Nagy I

更新日期：2011-07-20 00:00:00

abstract：:The conversion of cellular prion protein (PrP(C)) to its protease-resistant isoform is involved in the pathogenesis of prion disease. Although PrP(C) is a ubiquitous glycoprotein that is present in various cell types, the physiological role of PrP(C) remains obscure. The present study aimed to determine whether PrP(C)...

journal_title：Neuroscience letters

authors： Watanabe T,Yasutaka Y,Nishioku T,Kusakabe S,Futagami K,Yamauchi A,Kataoka Y

更新日期：2011-06-01 00:00:00

abstract：:The expression of class I and class II histocompatibility antigens by myelin basic protein (MBP)-positive oligodendrocytes, in response to exogenous cytokines, has been investigated in vitro. It has been found that interferon-gamma (IFN-gamma), although capable of class I induction, does not induce class II on oligode...

journal_title：Neuroscience letters

authors： Turnley AM,Miller JF,Bartlett PF

更新日期：1991-02-11 00:00:00