Abstract:
:During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5 degrees C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos increased in the suprachiasmatic nucleus (SCN) of the hypothalamus, the mammalian circadian clock, during deep hibernation and peaked during the arousal from hibernation. The pattern of increase in c-fos messenger RNA seen in the SCN by in situ hybridization was similar to that seen by Northern blot analysis of total hypothalamic RNA. The induction of c-fos may reflect a wake-up signal, increasing transcription of genes required in the euthermic state.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Bitting L,Sutin EL,Watson FL,Leard LE,O'Hara BF,Heller HC,Kilduff TSdoi
10.1016/0304-3940(94)90723-4subject
Has Abstractpub_date
1994-01-03 00:00:00pages
117-21issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(94)90723-4journal_volume
165pub_type
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