Abstract:
:The influence of testosterone on the postnatal development of reflex electromyographic (EMG) jaw muscle activity evoked by injection of mustard oil (MO) into the temporomandibular joint region and the later recurrence of this EMG activity after intravenous injection of naloxone, was studied in male rats. MO-evoked EMG activity in the contralateral digastric muscle and naloxone-induced recurrence of this EMG activity were fully developed in intact, 8-week-old rats. Castration at 4 weeks of age inhibited the development of the contralateral MO-evoked EMG activity, but did not influence the naloxone-induced recurrence. Contralateral MO-evoked responses were observed in 8-week-old castrated rats if they received testosterone replacement therapy beginning at 4 weeks of age. These data suggest that testosterone is required for the development of a contralateral nociceptive reflex in the digastric muscle of male rats.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Seo K,Fujiwara N,Cairns BE,Someya Gdoi
10.1016/s0304-3940(02)01173-4keywords:
subject
Has Abstractpub_date
2002-12-25 00:00:00pages
107-10issue
2eissn
0304-3940issn
1872-7972pii
S0304394002011734journal_volume
335pub_type
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