Abstract:
:Using immunohistochemistry we studied the presence of calbindin in myenteric neurones of the guinea-pig stomach. A rabbit anti recombinant rat calbindin-D28k (CALB) stained 12, 12 and 25% of all myenteric neurones in the fundus, corpus and antrum, respectively. A rabbit anti recombinant human CALB stained 4, 4 and 16%, respectively. A mouse monoclonal antibody against the chicken intestinal CALB showed no labelling. In all regions most calbindin neurones were additionally choline acetyltransferase (ChAT) positive while only a small proportion exhibited nicotinamide adenosine dinucleatide phosphate (NADPH)-diaphorase-activity. Numerous calbindin-positive varicose nerve fibres were present within myenteric ganglia, rarely detectable in the muscle layers and virtually absent in the mucosa. This study demonstrated that a supopulation of cholinergic myenteric neurones in the stomach contain calbindin and suggested that many of these neurones fulfil interneuronal tasks.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Reiche D,Pfannkuche H,Michel K,Hoppe S,Schemann Mdoi
10.1016/s0304-3940(99)00471-1keywords:
subject
Has Abstractpub_date
1999-07-30 00:00:00pages
71-4issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00471-1journal_volume
270pub_type
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