Abstract：
:The nicotinic acetylcholine receptor (nAChR) antagonist alpha-bungarotoxin (alpha-Btx) binds to two different classes of high affinity binding sites from the Drosophila central nervous system. We have used the bivalent reagent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDAC) to cross-link 125I-alpha-Btx (M(r) = 8 kDa) to Drosophila head membranes. Upon sodium dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE), one major adduct of M(r) approximately 50 kDa was identified, suggesting that a 42 kDa polypeptide binds the toxin. Adduct formation was inhibited by other cholinergic ligands. Detergent-solubilized receptor complexes containing the cross-linked products were immunoprecipitated by antisera against two nAChR subunits previously identified by molecular cloning, the ALS and ARD proteins, suggesting that the 42 kDa toxin binding polypeptide constitutes a component of the previously described class 1 alpha-Btx binding site.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schloss P,Mayser W,Gundelfinger ED,Betz Hdoi
10.1016/0304-3940(92)90204-kkeywords:
subject
Has Abstractpub_date
1992-09-28 00:00:00pages
63-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(92)90204-Kjournal_volume
145pub_type
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