Abstract:
:The effects have been investigated of anesthetic and convulsant barbiturates on the spontaneous and potassium-stimulated efflux of [3H]D-aspartate from rat cortex minislices. In concentrations (100 microM) which have previously been shown to alter calcium ATPase activity in synaptosomes, anaesthetic barbiturates depressed and convulsant barbiturates stimulated the spontaneous efflux of [3H]D-aspartate in a dose-dependent manner. The effects on the efflux of [3H]D-aspartate evoked by 44.7 mM KCl were similar, although one convulsant barbiturate (1,3M1B) was without effect. The results are discussed in terms of entry and removal of calcium ions from nerve terminals.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Willow M,Bornstein JC,Johnston GAdoi
10.1016/0304-3940(80)90324-9subject
Has Abstractpub_date
1980-06-01 00:00:00pages
185-90issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(80)90324-9journal_volume
18pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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