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Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy.

Abstract：

:The nuclear factor kappa B inducing kinase gene (NIK) is located near the region of the haplotype associated with progressive supranuclear palsy (PSP) in chromosome 17q. We have analysed the coding region of the NIK gene in PSP patients through single strand conformation polymorphism and direct sequencing, in order to investigate the possible existence of pathogenic mutations. A change in exon 15 consisting of a G/C variation in position 2839 was found. This change was then analysed through restriction endonuclease HphI in 40 PSP samples and 35 control samples, but no differences in allelic frequency were found between the PSP and control groups. Our results do not support a pathogenic role of the NIK gene in PSP.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Campdelacreu J,Ezquerra M,Muñoz E,Oliva R,Tolosa E

doi

10.1016/s0304-3940(03)00105-8

keywords:

subject

Has Abstract

pub_date

2003-04-10 00:00:00

pages

158-60

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304394003001058

journal_volume

340

pub_type

杂志文章

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