Abstract:
:We have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3beta (GSK-3beta), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kang UG,Jeon WJ,Kim Y,Chung CK,Park JB,Juhnn YS,Kim YSdoi
10.1016/j.neulet.2005.08.020keywords:
subject
Has Abstractpub_date
2005-12-30 00:00:00pages
171-5issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00936-5journal_volume
390pub_type
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