Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP.

abstract：:Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in...

journal_title：Neuroscience letters

authors： Mishima K,Tanaka T,Pu F,Egashira N,Iwasaki K,Hidaka R,Matsunaga K,Takata J,Karube Y,Fujiwara M

更新日期：2003-01-30 00:00:00

abstract：:The clinical efficacy of clozapine in treating schizophrenia may stem from its lack of receptor selectivity. If true, several clozapine-sensitive receptors may be co-expressed by neurons dysfunctional in schizophrenia. To test this hypothesis, neurons from the rat medial prefrontal cortex were acutely isolated and sub...

journal_title：Neuroscience letters

authors： Vysokanov A,Flores-Hernandez J,Surmeier DJ

更新日期：1998-12-24 00:00:00

abstract：:Amyloid beta (A beta) is a normal proteolytic fragment of a large precursor protein (beta PP) which undergoes altered conformation, leading to fibril formation. Two main beta PP processing pathways have been described, and we are now reporting the characterization of a third beta PP pathway. A membrane-associated 16 k...

journal_title：Neuroscience letters

authors： Ghiso J,Gardella JE,Liem L,Gorevic PD,Frangione B

更新日期：1994-04-25 00:00:00

abstract：:Painful vincristine (VCR) neuropathy is a frequent and dose-limiting problem in cancer treatment. Here, we investigated how pain behavior is modulated in mice lacking the serotonin transporter (5-HTT-/- mice) after inducing neuropathy by intraperitoneal injections of VCR. We used standard tests for evoked pain, high p...

journal_title：Neuroscience letters

authors： Hansen N,Uçeyler N,Palm F,Zelenka M,Biko L,Lesch KP,Gerlach M,Sommer C

更新日期：2011-05-16 00:00:00

abstract：:As a variant of peptide conantokin-T (con-T), con-T[M8Q] is derived from the venom of Conus tulipa. Our previous study has demonstrated that con-T[M8Q] selectively targets N-methyl-d-aspartate receptor (NMDAR) NR2B subunit. In the present study, we determined the effects of con-T[M8Q] on the expression and development...

journal_title：Neuroscience letters

authors： Ren B,Zhou Z,Liu Z,Li B,Ou J,Dai Q

更新日期：2015-06-15 00:00:00

abstract：:The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic and uric acid were measured in rat brain in vivo using microdialysis coupled to HPLC with ultra violet spectrophotometry. Treatment with kainic acid at pH 4.1 (50 nmol) caused a significant increase in ...

journal_title：Neuroscience letters

authors： Waterfall AH,Singh G,Fry JR,Marsden CA

更新日期：1995-11-10 00:00:00

abstract：:Recently we have demonstrated the presence of a gap in the avian retinotectal projection, that corresponds with the locus of retinotopic representation of the elongated optic nerve head. The present report describes an equivalent gap in the optic neuropiles of the avian ventral geniculate nucleus and griseum tectalis ...

journal_title：Neuroscience letters

authors： Puelles L,Martinez S,Martinez-de-la-Torre M

更新日期：1988-02-15 00:00:00

abstract：:Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H2O2 alone or in combinati...

journal_title：Neuroscience letters

authors： Sewerynek E,Poeggeler B,Melchiorri D,Reiter RJ

更新日期：1995-08-11 00:00:00

abstract：:We have analyzed the size of the expanded poly(CAG) associated with juvenile Huntington disease in the cerebra and the cerebella of five patients. The expanded poly(CAG) was always longer in the cerebrum than in the cerebellum, but the difference in size varied from patient to patient. Except for one patient who posse...

journal_title：Neuroscience letters

authors： Kahlem P,Djian P

更新日期：2000-06-09 00:00:00

abstract：:Genetic factors play an important role in Parkinson's disease (PD) and vary from different races. A previous genome-wide association study (GWAS) identified 17 novel risk loci that were associated with PD in Caucasians. Several subsequent studies investigated the association between these loci and PD in Chinese popula...

journal_title：Neuroscience letters

authors： Hu X,Mao C,Hu Z,Zhang Z,Zhang S,Yang Z,Fan Y,Fan L,Zheng H,Yang J,Liu Y,Yuan Y,Wang Y,Shi C,Xu Y

更新日期：2020-04-23 00:00:00

abstract：:RGS (regulators of G protein signaling) proteins negatively regulate the alpha subunit of G proteins by accelerating their intrinsic GTPase activity. In a previous work, we reported the cloning of a cDNA encoding for a new RGS protein, RET-RGS. We showed that it is specifically expressed in the retina, notably by phot...

journal_title：Neuroscience letters

authors： Faurobert E,Scotti A,Hurley JB,Chabre M

更新日期：1999-07-02 00:00:00

abstract：:Individual activation of nicotinic acetylcholine receptor (nAChR) or nitric oxide (NO) synthase in the dorsal facial area (DFA) increases blood flow of common carotid artery (CCA) supplying intra- and extra-cranial tissues. We investigated whether the activation of nAChR initiated the activation of NO synthase and gua...

journal_title：Neuroscience letters

authors： Gong CL,Leung YM,Huang YP,Lin NN,Hung YW,Lee TJ,Kuo JS

更新日期：2010-12-17 00:00:00

abstract：:Zebra finches are ideal animals to investigate sex difference in songbirds. Only males can sing. The brain nuclei controlling song learning and production in males are considerably larger than in females. The robust nucleus of the arcopallium (RA) is a premotor nucleus, playing a key role in controlling singing. RA re...

journal_title：Neuroscience letters

authors： Wang S,Meng W,Liu S,Liao C,Huang Q,Li D

更新日期：2014-10-17 00:00:00

abstract：:Local delivery of cytokines or other immunomodulatory components has been applied as a potential therapy for experimental autoimmune encephalomyelitis (EAE), which is used as a model of human multiple sclerosis. We have used herpes simplex virus-based vectors expressing Th2 cytokines IL-4 and IL-10 and have previously...

journal_title：Neuroscience letters

authors： Broberg EK,Salmi AA,Hukkanen V

更新日期：2004-07-08 00:00:00

abstract：:Knowledge about the typical colors associated with familiar everyday objects (i.e., strawberries are red) is well-known to be represented in the conceptual semantic system. Evidence that such knowledge may also play a role in early perceptual processes for object recognition is scant. In the present ERP study, partici...

journal_title：Neuroscience letters

authors： Lu A,Xu G,Jin H,Mo L,Zhang J,Zhang JX

更新日期：2010-01-29 00:00:00

abstract：:Cigarette smoking is highly addictive and modern genetic research has identified robust genetic influences on nicotine dependence. An important step in translating these genetic findings to clinical practice is identifying the genetic factors affecting smoking cessation in order to enhance current smoking cessation tr...

journal_title：Neuroscience letters

authors： Chen LS,Horton A,Bierut L

更新日期：2018-03-16 00:00:00

abstract：:Gastrin releasing peptide (GRP) is involved in the stimulation of gastric acid release from the stomach. It also mediates effects on feeding behavior. It is associated with anorexigenic effects in both mammalian and avian species, but the mechanism of action is unknown in any species. The aim of the present study was ...

journal_title：Neuroscience letters

authors： Bohler M,Dougherty C,Tachibana T,Gilbert ER,Cline MA

更新日期：2019-11-20 00:00:00

abstract：:Many recent studies have revealed the consistency of anticipatory postural adjustments preceding single leg movements, such as stepping, in standing humans. These adjustments appear to involve an active lateral transfer of weight to the stance leg. The present study demonstrates that these anticipatory adjustments oft...

journal_title：Neuroscience letters

authors： McIlroy WE,Maki BE

更新日期：1993-12-24 00:00:00

abstract：:The enzyme horseradish peroxidase (HRP) has been applied to the proximal stumps of severed thoracic and lumbar dorsal roots in the turtles Pseudemys scripta elegans and Testudo hermanni. The results obtained confirm the distribution pattern observed with anterograde degeneration techniques. Primary afferent terminal s...

journal_title：Neuroscience letters

authors： Kusuma A,ten Donkelaar HJ

更新日期：1979-10-01 00:00:00

abstract：:During horizontal optokinetic stimulation (moving random dot pattern) in freely standing cats, gaze, head, and eye movements were measured with the search coil technique. The position values ('beating field') were evaluated. Gaze position depended on stimulus direction and stimulus velocity; it shifted to where the st...

journal_title：Neuroscience letters

authors： Schweigart G

更新日期：1995-01-02 00:00:00

abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...

journal_title：Neuroscience letters

authors： Guo JF,Dong XL,Xu Q,Li N,Yan XX,Xia K,Tang BS

更新日期：2015-09-14 00:00:00

abstract：:The blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), formed by interactions of tight junctions (TJs) in the endothelia or the choroids plexus, respectively, are important diffusion barriers between systemic circulation and neural tissue of the central nervous system (CNS). Epidemiological incid...

journal_title：Neuroscience letters

authors： Kang HS,Ahn HS,Kang HJ,Gye MC

更新日期：2006-07-10 00:00:00

abstract：:Adult filum terminale (FT) is an atypical region from where multipotent neural progenitor cells (NPCs) have been isolated. However, poor neuronal differentiation rate of FT-NPCs currently limits their clinical applications. Using custom-designed electric fields (EFs), this study sets up a method to significantly impro...

journal_title：Neuroscience letters

authors： Dong ZY,Pei Z,Li Z,Wang YL,Khan A,Meng XT

更新日期：2017-06-09 00:00:00

abstract：:The present study examined effects of high altitude exposure, which leads to development of hypoxia, on epiplexus cells associated with the choroid plexus in adult rats. At 2-5 h following exposure, epiplexus cells expressing inducible nitric oxide synthase (iNOS) were commonly observed. Increased expression of comple...

journal_title：Neuroscience letters

authors： Wang D,Kaur C

更新日期：2000-05-19 00:00:00

abstract：:Among the techniques used to reduce spatial neglect's symptoms, left neck muscle vibration (NMV) is alluring because it does not require the patient's attentional co-operation. The aim of this study was to determine the type of NMV-associated feedback that induced the most intense and longest-lasting egocentric post-e...

journal_title：Neuroscience letters

authors： Ceyte H,Beis JM,Ceyte G,Caudron S

更新日期：2021-01-19 00:00:00

abstract：:Generation of free radicals and subsequent lipid peroxidation have been proposed to contribute to delayed tissue damage following traumatic spinal cord injury (SCI). Ubiquinols (reduced coenzyme Q), ascorbate (vitamin C), and alpha-tocopherol (vitamin E) are endogenous antioxidants; decreases in tissue levels of these...

journal_title：Neuroscience letters

authors： Lemke M,Frei B,Ames BN,Faden AI

更新日期：1990-01-01 00:00:00

abstract：:Oleamide is a recently described lipid, obtained from the cerebrospinal fluid of sleep-deprived cats. It has been observed that oleamide possesses several biological effects, such as sleep induction, and immunological suppression as well as serotonin and gamma-aminobutyric acid receptors activation. In addition, oleam...

journal_title：Neuroscience letters

authors： Murillo-Rodríguez E,Giordano M,Cabeza R,Henriksen SJ,Méndez Díaz M,Navarro L,Prospéro-García O

更新日期：2001-11-02 00:00:00

abstract：:Learning is important for humans and can be disrupted by disease. However, the essence of how learning may be represented within a neuronal network is still elusive. Spike trains generated by neurons have been demonstrated to carry information which is relevant for learning. The present study uses well-established mut...

journal_title：Neuroscience letters

authors： Jog MS,Aur D,Connolly CI

更新日期：2007-01-22 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor blocker 2-amino-5-phosphonovaleric acid [+/-)-2-APV) and kynurenic acid both suppressed spontaneous epileptiform burst discharges in the CA3 region of rat hippocampal slices. When the bursts were induced by perfusion with magnesium-free medium (+/-)-2-APV was the more potent in...

journal_title：Neuroscience letters

authors： Stone TW

更新日期：1988-01-22 00:00:00

abstract：:We have previously shown that 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), an inhibitor of protein kinase C, inhibits proliferation of neuroblastoma cells in culture. We have now tested whether the effect of H7 is mediated by MAP kinase and Raf. It is shown that, in Neuro 2a cells, activation of protein kinase...

journal_title：Neuroscience letters

authors： Cabedo H,Felipo V,Miñana MD,Grisolía S

更新日期：1996-08-16 00:00:00