Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice.

Abstract:

:Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. Alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that alpha-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Mishima K,Tanaka T,Pu F,Egashira N,Iwasaki K,Hidaka R,Matsunaga K,Takata J,Karube Y,Fujiwara M

doi

10.1016/s0304-3940(02)01293-4

keywords:

subject

Has Abstract

pub_date

2003-01-30 00:00:00

pages

56-60

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304394002012934

journal_volume

337

pub_type

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