Abstract:
:In neuro-inflammatory diseases, activated T cells are thought to drive the inflammatory process. In this study, we investigated the potential role of three T cell attracting chemokines (CK) in neuro-inflammation. For this purpose, we measured levels of CXCL16, CCL17 and CCL18 in matched serum and cerebrospinal fluid (CSF) samples of patients with different neurological diseases. Interestingly, CXCL16 levels were significantly elevated in the CSF and were higher in inflammatory disease than in controls, whereas CCL17 and CCL18 were absent in the CSF. CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
le Blanc LM,van Lieshout AW,Adema GJ,van Riel PL,Verbeek MM,Radstake TRdoi
10.1016/j.neulet.2005.12.029keywords:
subject
Has Abstractpub_date
2006-04-10 00:00:00pages
145-8issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)01396-0journal_volume
397pub_type
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