Opposite effects of cyclohexyladenosine and theophylline on hypoxic damage in cultured neurons.

abstract：:To investigate the acute effects of whole-body cryotherapy (WBC) on postural control, we measured postural sway (COP) in a quiet stance with eyes open in four consecutive 20-second tests: before and 1, 6 and 11min after the WBC. Twenty-four healthy young subjects aged 19.3±0.9 were exposed to WBC (-110°C) for 2min. Th...

journal_title：Neuroscience letters

authors： Giemza C,Czech P,Paluszak A,Bieć E,Borzucka D,Kuczyński M

更新日期：2013-03-01 00:00:00

abstract：:Lowering of the pH of the superfusion solution (physiological phosphate buffers derived from normal Krebs solution) of mucosa-free muscle strips of the guinea-pig urinary bladder from 7.4 to 6 or 5, produced a marked increase of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) outflow (total evoked rele...

journal_title：Neuroscience letters

authors： Geppetti P,Tramontana M,Patacchini R,Del Bianco E,Santicioli P,Maggi CA

更新日期：1990-06-22 00:00:00

abstract：:Release of endogenous polyamines may contribute to neuronal loss in ischemia and related conditions. Primary cortical neurons were exposed to spermine and spermidine and subsequently assayed for [3H]ouabain binding to quantify neuronal loss. Neuronal survival was significantly decreased in the presence of spermine at ...

journal_title：Neuroscience letters

authors： Fahey JM,Pritchard GA,Miller LG

更新日期：1993-10-14 00:00:00

abstract：:The effects of several Ca2+ channel blockers were evaluated on inhibitory junction potential (IJP) evoked in rat colonic circular muscle by electrical field stimulation (EFS). Glass microelecrodes were used to record membrane potential of smooth muscle cells. IJPs were tetrodotoxin-sensitive (1 microM) and disappeared...

journal_title：Neuroscience letters

authors： Borderies JR,Jiménez M,Angel F

更新日期：1996-05-31 00:00:00

abstract：:As noted in the aging literature, processing delays often occur in the central nervous system with increasing age, which is often attributable in part to demyelination. In addition, differential slowing between sensory systems has been shown to be most discrepant between visual (up to 20ms) and auditory systems (<5ms)...

journal_title：Neuroscience letters

authors： Stephen JM,Knoefel JE,Adair J,Hart B,Aine CJ

更新日期：2010-10-22 00:00:00

abstract：:It is well established that the reinforcing effect of drugs of abuse is linked to the mesolimbic dopamine (DA) system. Morphine produces an increase in DA release in the brain, which may provide positive reinforcement contributing to the development of motivational aspects of drug-seeking and maintenance behavior. Sev...

journal_title：Neuroscience letters

authors： Yoon SS,Lee BH,Kim HS,Choi KH,Yun J,Jang EY,Shim I,Kim JA,Kim MR,Yang CH

更新日期：2007-11-20 00:00:00

abstract：:Day-night variations of gastrin releasing peptide (GRP) in the neuronal somal area of the SCN and the nearby region on the anterior hypothalamic area (AHA) where GRP fibers project, were examined by semiquantitative immunocytochemistry, and compared with those of vasoactive intestinal peptide (VIP). Both in the SCN an...

journal_title：Neuroscience letters

authors： Okamura H,Ibata Y

更新日期：1994-11-07 00:00:00

abstract：:The effects of tetrahydro-9-aminoacridine (THA) on beta-adrenoceptor activation-induced synaptic potentiation were studied in brain slices of the rat amygdala using intracellular recording techniques. To exclude the involvement of N-methyl-D-aspartate (NMDA) receptors, all the experiments were performed in the presenc...

journal_title：Neuroscience letters

authors： Wang SJ,Huang CC,Hsu KS,Tsai JJ,Huang CC,Gean PW

更新日期：1996-08-23 00:00:00

abstract：:Nerve ligation injury in rats may represent a useful model of some clinical neuropathic pains. Activation of N-methyl-D-aspartate (NMDA) receptors may maintain central sensitivity and contribute to neuropathic pain. Here, nerve injury was produced by unilateral ligation of the L5 and L6 spinal roots of the sciatic ner...

journal_title：Neuroscience letters

authors： Ossipov MH,Lopez Y,Nichols ML,Bian D,Porreca F

更新日期：1995-10-20 00:00:00

abstract：:The phenotypic manifestation of McArdle disease varies considerably from one individual to the next. The purpose of this study was to assess the possible association between the clinical severity of the disease, and each of the genotypes PYGM (R50X), ACE (I/D), AMPD1 (Q12X), PPARGC1A (G482S) and ACTN3 (R577X). We also...

journal_title：Neuroscience letters

authors： Rubio JC,Gómez-Gallego F,Santiago C,García-Consuegra I,Pérez M,Barriopedro MI,Andreu AL,Martín MA,Arenas J,Lucia A

更新日期：2007-07-18 00:00:00

abstract：:We examined the effect of lateral (visceral) and medial (gustatory) parabrachial nucleus (PBN) lesions on the suppression of milk intake induced with cholecystokinin (CCK) in 24 h food-deprived rats. Irrespective of CCK dose, each type of PBN lesion significantly elevated the consumption of milk. Neither medial nor la...

journal_title：Neuroscience letters

authors： Trifunovic R,Reilly S

更新日期：2003-09-11 00:00:00

abstract：:Recently a full genome survey detected an allelic association between Alzheimer's disease (AD) and the D10S1423 marker on chromosome 10p12-14 (40 cM from the telomere). In this study we examined the D10S1423 marker in an ethnically homogeneous German population of 80 AD patients and two groups of controls, 168 healthy...

journal_title：Neuroscience letters

authors： Majores M,Bagli M,Papassotiropoulos A,Schwab SG,Jessen F,Rao ML,Maier W,Heun R

更新日期：2000-08-11 00:00:00

abstract：:We have previously shown that treatment of cultured dorsal root ganglion neurons (DRGN) with a highly specific, reversible acetylcholinesterase (AChE) inhibitor, BW284c51, retards neuritic outgrowth in a dose dependent manner and is accompanied by the presence of abnormal, perikaryal neurofilament (NF) inclusions in a...

journal_title：Neuroscience letters

authors： Dupree JL,Maynor EN,Bigbee JW

更新日期：1995-09-01 00:00:00

abstract：:A highly significant endogenous lateral asymmetry in striatal dopamine (D2) receptors was found utilizing the binding of [3H]spiroperidol (0.6 nM) to homogenates prepared from the left and the right striata of male rats individually assayed. The mean level of binding was 23% greater in left than in right striatum, whi...

journal_title：Neuroscience letters

authors： Schneider LH,Murphy RB,Coons EE

更新日期：1982-12-13 00:00:00

abstract：:The effects of methamphetamine (MAP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in the rat brain. A single administration of MAP induced dose-dependent and reversible increases in NTLI in the caudate-putamen, limbic forebrain and midbrain. NTLI in the caudate-putamen, limbic forebrain...

journal_title：Neuroscience letters

authors： Wachi M,Okuda M,Togashi S,Miyashita O,Wakahoi T

更新日期：1987-07-22 00:00:00

abstract：:The strict photoperiodic dependence of gonadotropic function observed in mink provides an excellent physiological model for studying the activity of GnRH hypothalamic neurons. In mink, exposure to more than 10 h light inhibits the activity of this neurohormonal system. Melatonin plays an essential role in this type of...

journal_title：Neuroscience letters

authors： Boissin-Agasse L,Barberis C,Audigier S,Roch G,Boissin J

更新日期：1992-09-14 00:00:00

abstract：:Cytoplasmic acidification in taste receptor cells is thought to be involved, at least in part, in acid taste transduction. Since in taste buds about 20% of the receptor cells are electrically coupled, we have tested whether reduction in intracellular pH affects these lateral synaptic interactions. By applying the patc...

journal_title：Neuroscience letters

authors： Bigiani A,Roper SD

更新日期：1994-08-01 00:00:00

abstract：:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the ...

journal_title：Neuroscience letters

authors： Saxon DW

更新日期：2003-03-13 00:00:00

abstract：:Using a combination of intracellular recording and morphological techniques, we describe the properties of a new cell type within layer II of the lateral entorhinal cortex. A thick and bifurcating apical dendrite and thinner basal dendrites extended from the pyramidal shaped cell body. The axon ramified within all sup...

journal_title：Neuroscience letters

authors： Empson RM,Gloveli T,Schmitz D,Heinemann U

更新日期：1995-07-07 00:00:00

abstract：:Acute urinary bladder distension (AUBD) and colorectal distension (CRD) activated mechanical afferents from the urinary bladder and colon and the activated afferent signaling affected visceral organ behavior. AUBD and CRD have been reported to affect the arterial blood pressure (ABP) response in the rat. We hypothesiz...

journal_title：Neuroscience letters

authors： Chen SS,Yang CC,Chien CT

更新日期：2008-10-10 00:00:00

abstract：:Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) product...

journal_title：Neuroscience letters

authors： Cox BA,Johnson SW

更新日期：1998-10-23 00:00:00

abstract：:Parkinson's disease (PD) is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Adenosine is a neuromodulator that inhibit the release of dopamine via a disinhibitory mechanism. In this study, we investigated the neuroprotective effect of 8-cyclopentyl-1,3-dipropylxanthine and...

journal_title：Neuroscience letters

authors： Fathalla AM,Soliman AM,Moustafa AA

更新日期：2017-03-16 00:00:00

abstract：:CREATE (Consider, Read, Elucidate hypotheses, Analyze and interpret data, Think of the next Experiment) is a pedagogical approach for teaching and learning science through the rigorous analysis of primary scientific literature. This mini-review focuses on the tools, assignments, and in-class activities by which this s...

journal_title：Neuroscience letters

authors： Pugh-Bernard A,Kenyon KL

更新日期：2021-01-18 00:00:00

abstract：:We tested the hypothesis that intracerebroventricular (i.c.v.) administration of leptin would increase mean arterial pressure (MAP) in ad libitum (AL) fed and food deprived (FD) normotensive rats. Male Sprague-Dawley rats were chronically instrumented with a guide cannula directed at the lateral ventricle and a caroti...

journal_title：Neuroscience letters

authors： Casto RM,VanNess JM,Overton JM

更新日期：1998-04-17 00:00:00

abstract：:The beta-carbolines, methyl-beta-carboline-3-carboxylate (beta-CCM) and 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) are known to have pharmacological properties opposite to those of agonistic benzodiazepines. Convulsions induced by these drugs lead to differential patterns, such as clonus, myoclonic or t...

journal_title：Neuroscience letters

authors： Martin B,Desforges C,Chapouthier G

更新日期：1991-11-25 00:00:00

abstract：:In the rat the response of suprachiasmatic nucleus neurons to steady retinal illumination at different adaptation luminances was studied. The results confirm that in this nucleus the discharge rate is more commonly increased than suppressed by light. Interval histograms indicate that a complex process underlies the di...

journal_title：Neuroscience letters

authors： Groos G,Mason R

更新日期：1978-04-01 00:00:00

abstract：:Cerebral ischemia-reperfusion (I/R)-induced brain tissue injury is a major obstacle for acute stroke management. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is reported to play a critical role in the regulation of myocardial or hepatic I/R injury. However, its role in cerebral I/R remains elu...

journal_title：Neuroscience letters

authors： Liu Y,Guo Y

更新日期：2021-01-19 00:00:00

abstract：:The objective of this study was to investigate whether berberine in Coptidis Rhizoma extract could be transported in primary cultured cerebral neurons and to study the uptake and transport behavior of berberine through the neurons. The present results showed that the uptake of berberine by the neurons increased linear...

journal_title：Neuroscience letters

authors： Wang X,Xing D,Wang W,Lei F,Su H,Du L

更新日期：2005-05-06 00:00:00

abstract：:We evaluated the therapeutic effects of remacemide hydrochloride, an N-methyl-D-aspartate (NMDA) receptor-associated ionophore blocker with sodium channel blocking activity, on cortical lesion volume and memory dysfunction following parasagittal fluid-percussion brain injury in the anesthetized rat. We found that intr...

journal_title：Neuroscience letters

authors： Smith DH,Perri BR,Raghupathi R,Saatman KE,McIntosh TK

更新日期：1997-08-15 00:00:00

abstract：:Imaging studies indicate smaller orbitofrontal cortex (OFC) volume in mood disorder patients compared with healthy subjects. We sought to determine whether child and adolescent patients with bipolar disorder have smaller OFC volumes than healthy controls. Fourteen children and adolescents meeting DSM-IV criteria for b...

journal_title：Neuroscience letters

authors： Najt P,Nicoletti M,Chen HH,Hatch JP,Caetano SC,Sassi RB,Axelson D,Brambilla P,Keshavan MS,Ryan ND,Birmaher B,Soares JC

更新日期：2007-02-21 00:00:00