Abstract：
:The effects of several Ca2+ channel blockers were evaluated on inhibitory junction potential (IJP) evoked in rat colonic circular muscle by electrical field stimulation (EFS). Glass microelecrodes were used to record membrane potential of smooth muscle cells. IJPs were tetrodotoxin-sensitive (1 microM) and disappeared in Ca(2+)-free solution. L-type calcium channels blockers, such as nifedipine (1 microM) or verapamil (1 microM), did not affect IJPs. IJPs were significantly reduced by omega-conotoxin GVIA (300 nM), an N-type Ca2+ channel blocker. IJPs were resistant to omega-agatoxin IVA (50 nM), a P-type Ca2+ channel blocker, and omega-conotoxin MVIIC (1 microM), which blocks both N- and Q-type Ca2+ channels at micromolar concentrations. We conclude that the release of NANC neurotransmitter-mediating IJPs in the rat colon evoked by EFS involves N-type Ca2+ channels. The fact that omega-conotoxin GVIA does not abolish the IJPs suggests a putative role for L-, P- or Q-type Ca2+ channels.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Borderies JR,Jiménez M,Angel Fdoi
10.1016/0304-3940(96)12671-9subject
Has Abstractpub_date
1996-05-31 00:00:00pages
91-4issue
2eissn
0304-3940issn
1872-7972pii
0304394096126719journal_volume
210pub_type
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