Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid.

abstract：:The synapsin III gene, SYN3, which belongs to the family of synaptic vesicle-associated proteins, has been implicated in the modulation of neurotransmitter release and in synaptogenesis, suggesting a potential role in several neuropsychiatric diseases. The human SYN3 gene is located on chromosome 22q12-13, a candidate...

journal_title：Neuroscience letters

authors： Chen Q,Che R,Wang X,O'Neill FA,Walsh D,Tang W,Shi Y,He L,Kendler KS,Chen X

更新日期：2009-11-20 00:00:00

abstract：:Experimental Scrapie in hamster is a simple, reproducible model of prion diseases that occur in humans and animals. Stereotaxic microinoculation (0.5 microliter) of the agent (263 K) into a specific cerebral structure (striatum) in hamster, previously developed in our group, gives the opportunity to further investigat...

journal_title：Neuroscience letters

authors： Grégoire N,Lebrun F,Fahn L,Salamon G,Nicoli J

更新日期：1993-12-12 00:00:00

abstract：:The effects of severe hypoglycemia on perforant path-evoked field potentials were examined in the rat hippocampus. Although a complete loss of this response was noted when blood glucose concentration fell below 1 mM, this occurred before cessation of electroencephalogram (EEG) activity. Both spontaneous and evoked res...

journal_title：Neuroscience letters

authors： Butcher SP,Jacobson I,Sandberg M,Hagberg H,Hamberger A

更新日期：1987-05-19 00:00:00

abstract：:The prenatal development of axonal connections in the rat olfactory system was studied using DiI. On day 16 (E16), the olfactory and vomeronasal nerves extended from the olfactory epithelia to the olfactory bulb (OB), the terminal nerve to the telencephalic septum, while axons of mitral and tufted cells reached the an...

journal_title：Neuroscience letters

authors： Marchand R,Bélanger MC

更新日期：1991-08-19 00:00:00

abstract：:Functional neuroimaging data have shown that mental calculation involves fronto-parietal areas that are composed of different subsystems shared with other cognitive functions such as working memory and language. Event-related potential (ERP) analysis has also indicated sequential information changes during the calcula...

journal_title：Neuroscience letters

authors： Ku Y,Hong B,Gao X,Gao S

更新日期：2010-03-12 00:00:00

abstract：:Estrogen not only modulates nigrostriatal function but also developmental processes in the striatum. Recently, we have demonstrated the presence of the estrogen-synthesizing enzyme aromatase in the developing mouse striatum. This study is concerned with the expression of estrogen receptor-alpha/beta (ER) mRNA in the d...

journal_title：Neuroscience letters

authors： Küppers E,Beyer C

更新日期：1999-12-03 00:00:00

abstract：:This report concerns an ultrastructural study of the synapses present on the surface of somata of normal-looking Betz cells in the fifth layer of motor cortex of seven patients with amyotrophic lateral sclerosis (ALS). Specimens from 12 age-matched, neurologically normal control individuals were included for compariso...

journal_title：Neuroscience letters

authors： Sasaki S,Iwata M

更新日期：1999-06-11 00:00:00

abstract：:Nerve fibers immunoreactive for vasoactive intestinal polypeptide (VIP) were demonstrated by immunocytochemistry in the dog and rat kidney. They were seen in association with the renal artery and its branches. In the dog, VIP-immunoreactive fibers were rarely seen close to small blood vessels suggestive of arterioles....

journal_title：Neuroscience letters

authors： Barajas L,Sokolski KN,Lechago J

更新日期：1983-12-30 00:00:00

abstract：:A two pulse technique was used to study the decay of mechanical activation in TTX poisoned mouse extensor digitorum longus (EDL) and soleus muscle fibres. A two microelectrode point voltage clamp technique was used with visual endpoint determination of the threshold potential for activation. The excitatory effect of a...

journal_title：Neuroscience letters

authors： Dulhunty AF

更新日期：1979-10-01 00:00:00

abstract：:Numerous studies have provided evidence that physical activity promotes cortical plasticity in the adult brain and in turn facilitates learning. However, until now, the effect of simultaneous physical activity (e.g. bicycling) on learning performance has not been investigated systematically. The current study aims at ...

journal_title：Neuroscience letters

authors： Schmidt-Kassow M,Kulka A,Gunter TC,Rothermich K,Kotz SA

更新日期：2010-09-20 00:00:00

abstract：:We have prepared dissociated cell cultures from adult rat optic nerve. After 48 h in culture cells of both fibroblastic and process-bearing morphology could be recognised. Using indirect immunofluroescence and cell-type specific markers it was possible to unambiguously identify astrocytes and oligodendrocytes in cultu...

journal_title：Neuroscience letters

authors： Kennedy PG,Lisak RP

更新日期：1980-03-01 00:00:00

abstract：:Some granule neurons naturally undergo apoptosis in the external granular layer (EGL) of the postnatally developing rat cerebellum. We analyzed the developmental stage-specificity of this apoptosis using double staining by in situ nick end labeling and immunohistochemistry against three proteins expressed at specific ...

journal_title：Neuroscience letters

authors： Tanaka M,Marunouchi T

更新日期：1998-02-13 00:00:00

abstract：:This study examined the effect of gestational age of rat ventral mesencephalon (VM) on the characteristics of neurospheres generated from this region and on the yield of each cell type after differentiation of these neurospheres. Neurospheres generated from embryonic day (E) 12 and E13 VM had significantly larger diam...

journal_title：Neuroscience letters

authors： O' Keeffe GW,Sullivan AM

更新日期：2005-02-28 00:00:00

abstract：:We studied changes in the characteristics of action potentials of CA3 pyramidal cells accompanying electrographic seizure (EGS) induction, using an in vitro model similar to kindling. We found an increased propensity to fire action potentials which lack EPSPs or other triggering depolarizing potentials. Such 'baseline...

journal_title：Neuroscience letters

authors： Stasheff SF,Wilson WA

更新日期：1990-03-26 00:00:00

abstract：:Several studies have suggested an important role for brain-derived neurotrophic factor (BDNF) in the pathophysiology and therapeutics of bipolar disorder (BPD). The mechanisms underlying the therapeutic effects of lithium in BPD seem to involve a direct regulation of neurotrophic cascades. However, no clinical study e...

journal_title：Neuroscience letters

authors： de Sousa RT,van de Bilt MT,Diniz BS,Ladeira RB,Portela LV,Souza DO,Forlenza OV,Gattaz WF,Machado-Vieira R

更新日期：2011-04-20 00:00:00

abstract：:At postnatal day (PN)1, there are sex differences in gonadal receptor expression in the rat substantia nigra pars reticulata (SNR). Male pups have lower levels of androgen receptor (AR) and estrogen receptor (ER)beta immunoreactivity (IR) compared to female pups, while ERalpha IR is equally expressed in the two sexes....

journal_title：Neuroscience letters

authors： Ravizza T,Velísková J,Moshé SL

更新日期：2003-02-20 00:00:00

abstract：:The DNA-binding activity of nuclear factor (NF-kB) was found to be induced in the spinal cord of rats with experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), from the onset of the disease. This activation of NF-kB persisted throughout the disease period and decreased thereafter ...

journal_title：Neuroscience letters

authors： Pahan K,Schmid M

更新日期：2000-06-16 00:00:00

abstract：:Using immunohistochemistry with specific antisera against dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase, we present the first description of the adrenergic structures of the sheep medulla oblongata. Dopamine-beta-hydroxylase-immunoreactive perikarya in the sheep brain are localized as described ...

journal_title：Neuroscience letters

authors： Tillet Y

更新日期：1988-12-19 00:00:00

abstract：:Various exogenous and endogenous steroids have been demonstrated to have both enhancing and inhibiting effects on ligand binding to the gamma-aminobutyric acid(A) receptor (GABAA receptor) in previous studies. In the present study we have explored the possibility that an additional class of synthetic steroidal compoun...

journal_title：Neuroscience letters

authors： Masonis AE,McCarthy MP

更新日期：1995-04-07 00:00:00

abstract：:Rhythms of plasma melatonin levels were determined in lizards (Tiliqua rugosa) subjected to a 12 h photocycle (12 h light: 12 h dark) at constant 33 degrees C, and at 7 different thermoperiods (33 degrees C thermophase and 15 degrees C cryophase) whose thermophase duration ranged from 1.5 to 21 h. The melatonin secret...

journal_title：Neuroscience letters

authors： Firth BT,Kennaway DJ,Belan I

更新日期：1991-01-02 00:00:00

abstract：:The possible involvement of 2-amino-4-phosphonobutyrate (APB) recognition sites in mechanisms enabling the maintenance of long-term potentiation (LTP) was investigated in rat hippocampal slices. The action of D(-)- and L(+)-isomers of APB was tested on orthodromic EPSP and spike responses recorded extracellularly from...

journal_title：Neuroscience letters

authors： Reymann KG,Matthies H

更新日期：1989-03-27 00:00:00

abstract：:Behavioural sensitization to a single morphine exposure has been considered to be a long-term form of behavioural plasticity associated with opioid addiction. Accumulated evidence has shown that histone modification plays a key role in behavioural plasticity. Therefore, this study was designed to investigate whether t...

journal_title：Neuroscience letters

authors： Jing L,Luo J,Zhang M,Qin WJ,Li YL,Liu Q,Wang YT,Lawrence AJ,Liang JH

更新日期：2011-04-25 00:00:00

abstract：:[125I]Iodomelatonin ([125I]MEL) binding in chicken spinal cords was characterized. The specific binding of [125I]MEL to the membrane preparation of spinal cord was rapid, stable, saturable, reversible, specific and of high affinity. Scatchard analysis of the specific binding data indicated an equilibrium dissociation ...

journal_title：Neuroscience letters

authors： Wan Q,Pang SF

更新日期：1993-11-26 00:00:00

abstract：:Pain is the most characteristic feature of sickle cell disease (SCD). Patients with SCD live with unpredictable, recurrent episodes of acute painful crisis, as well as chronic unremitting pain throughout their lifetime. While most of the research and medical efforts have focused on treating vaso-occlusion crisis and a...

journal_title：Neuroscience letters

authors： He Y,Wang ZJ

更新日期：2019-07-27 00:00:00

abstract：:Human low back pain sometimes originates from lumbar facet joints. In human lumbar facet joint inflammation or degeneration, the referred pain is not only expanded into the low back area but also into the leg or foot. The rat L5-L6 facet joint is innervated by the L1-L5 dorsal root ganglia. The presence of brain-deriv...

journal_title：Neuroscience letters

authors： Ohtori S,Takahashi K,Moriya H

更新日期：2002-04-26 00:00:00

abstract：:There is evidence to support that oxidative stress is increased in Parkinson's disease (PD) and contributes to the degeneration of dopaminergic neurons. Recent research has shown that higher blood urate concentrations have now been linked to decreased risks and progression rates of PD. However, the mechanisms about ur...

journal_title：Neuroscience letters

authors： Zhu TG,Wang XX,Luo WF,Zhang QL,Huang TT,Xu XS,Liu CF

更新日期：2012-01-11 00:00:00

abstract：:Perception of limb position and motion is abnormal in Parkinson's disease (PD). Despite the fact that the processing of proprioceptive inputs is inherently temporal, most studies have assessed spatial aspects of proprioception in PD patients. Here, we use a recently described method to test whether deficits also exist...

journal_title：Neuroscience letters

authors： Fiorio M,Stanzani C,Rothwell JC,Bhatia KP,Moretto G,Fiaschi A,Tinazzi M

更新日期：2007-05-07 00:00:00

abstract：:A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031. In both rat and mouse, 125I-Bolton Hunter CCK binding in the region of the interpeduncular nucleus (IPN) ...

journal_title：Neuroscience letters

authors： Hill DR,Shaw TM,Woodruff GN

更新日期：1987-08-31 00:00:00

abstract：:By using a monoclonal antibody and polyclonal antibodies to human beta amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus w...

journal_title：Neuroscience letters

authors： Ohgami T,Kitamoto T,Tateishi J

更新日期：1992-02-17 00:00:00

abstract：:The pathogenetic mechanisms leading to progressive neurodegeneration in amyotrophic lateral sclerosis (ALS) have not been fully elucidated. One possible factor responsible for the selective motor neuron loss in the motor cortex, brain stem and spinal cord is glutamate-induced excitotoxicity particularly mediated via a...

journal_title：Neuroscience letters

authors： Petri S,Krampfl K,Hashemi F,Schmalbach S,Grothe C,Hori A,Dengler R,Bufler J

更新日期：2004-04-29 00:00:00