Abstract:
:The pathogenetic mechanisms leading to progressive neurodegeneration in amyotrophic lateral sclerosis (ALS) have not been fully elucidated. One possible factor responsible for the selective motor neuron loss in the motor cortex, brain stem and spinal cord is glutamate-induced excitotoxicity particularly mediated via alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) type glutamate receptors. Data about the expression pattern of AMPA receptors in the primary motor cortex are lacking so far. The pharmacological and physiological properties of AMPA receptors are defined by the heteromeric composition of the four different receptor subunits. Different expression patterns of these subunits at motor neurons may provide a molecular basis for increased vulnerability to excitotoxic damage. Using in situ hybridization histochemistry we did not detect any significant differences in the distribution of AMPA receptor mRNA in the motor cortex of ALS patients compared to controls.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Petri S,Krampfl K,Hashemi F,Schmalbach S,Grothe C,Hori A,Dengler R,Bufler Jdoi
10.1016/j.neulet.2004.03.002keywords:
subject
Has Abstractpub_date
2004-04-29 00:00:00pages
170-4issue
3eissn
0304-3940issn
1872-7972pii
S0304394004002617journal_volume
360pub_type
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