Abstract:
:The present study was aimed at investigating the role of gastrin in startle, startle habituation and prepulse inhibition (PPI). There were no significant differences between gastrin knockout mice and their wildtype controls in any of these baseline parameters. The disruption of PPI by treatment with 5 mg/kg of amphetamine was absent in gastrin knockout mice. However, a higher dose of amphetamine disrupted PPI in both genotypes. Similarly, treatment with the dopamine receptor agonist, apomorphine, the N-methyl-D-aspartate receptor antagonist, MK-801, and the serotonin-1A receptor agonist, 8-hydroxy-di-propylaminotetralin (8-OH-DPAT) modulated PPI similarly in gastrin knockout mice and wildtype controls. These data suggest a role of gastrin in the brain in modulating dopamine release in areas involved in PPI.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
van den Buuse M,van Driel IR,Samuelson LC,Pijnappel M,Martin Sdoi
10.1016/j.neulet.2004.10.013keywords:
subject
Has Abstractpub_date
2005-01-20 00:00:00pages
237-42issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(04)01263-7journal_volume
373pub_type
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